REFERENCES Acocella G, Nonis A, Perna G, Patane E, Gialdroni-Grassi G, Grassi C: Comparative bioavailability of isoniazid, rifampicin and pyrazinamide administered free and in a fixed triple formulation designed for daily use in antituberculosis chemotherapy. I. Single-dose study. Am Rev Resp Dis 1988, 138 : 882-885. Agrawal S, Ashokraj Y, Bharatam PV, Pillai O, Panchagnula R: Solid-state characterization of rifampicin samples and its biopharmaceutic relevance. Eur J Pharm Sci 2004 , 22 (2-3): 127-144. Agrawal S, Kaur KJ, Singh I, Bhade SR, Kaul CL, Panchagnula R: Assessment of bioequivalence of rifampicin, isoniazid and pyrazinamide in a four drug fixed dose combination with separate formulations at the same dose level . Int J Pharm 2002 , 233 (1-2): 169-177. Agrawal S, Panchagnula R: Dissolution test as a surrogate for quality evaluation of rifampicin containing fixed dose combination formulations. Int J Pharm 2004, 287 (1-2): 97-112. Ahsan F, Rivas IP, Khan MA, Torres Suarez AI: Targeting to macrophages: role of physicochemical properties of particulate carriers-liposomes and microspheres-on the phagocytosis by macrophages. J Contemp Relig 2002, 79 : 29-40. Ahuja S: Handbook of Pharmaceutical Analysis by HPLC (Separation Science and Technology). Vol. 6. Elsevier Inc., San Diego, USA. 2005. Ain Q, Sharma S, Garg SK, Khuller GK: Role of poly [DL-lactide-co-glycolide] in development of a sustained oral delivery system for antitubercular drug(s). Int J Pharm 2002 , 239 (1-2): 37-46. Allain C, Salome L: Gelation of semidilute polymer solutions by ion-complexation: Critical behavior of the rheological properties versus cross-linking. Macromolecules 1990, 23 : 981-987. Allémann E, Gurny R, Doelker E: Preparation of aqueous polymeric nanodispersions by a reversible salting-out process: influence of process parameters on particle size. Int J Pharm 1992, 87 (1-3): 247-253. Allémann E, Gurny R, Doelker E. Drug-loaded nanoparticles – preparation methods and drug targeting issues. Eur J Pharm Biopharm 1993, 39 : 173–191. Alloncle M, Doublier JL: Viscoelastic properties of maize starch/hydrocolloid pastes and gels. Food Hydrocoll. 1991, 5: 455-467. Almdal K, Dyre J, Hvidt S, Kramer O. Towards a phenomelogical definition of the term ‘gel’. Pol Net Gel 1992, 1: 5-17. Al-Sagheer F, Hey MJ: Hofmeister anion effects on aqueous solutions of poly(ethylene oxide) studied by attenuated total reflectance FT-IR spectroscopy. Coll Surf A: Physicochemical and Engineering Aspects 2004, 245 (1-3): 99-103. Amar HO, Khalil RM: Preparation and evaluation of sustained release solid dispersions of drugs with Eudragit polymers. Drug Dev Ind Pharm 1997 , 23 (11): 1043–1054. Anderson PW: More is Different. Science 1972, 177 , 393-396. Anisimova YV, Gelperina SI, Peloquin CA, Heifets LB: Nanoparticles as antituberculosis drugs carriers: effect on activity against mycobacterium tuberculosis in human monocyte-derived macrophages. J Nanopart Res 2000 , 2: 165-171. Anonymous: Interim Revision Announcement. Pharmacopeial Forum 27. 2001: 3232–3233. Ansel Howard C (editor): Introduction to Pharmaceutical Dosage Forms. Lea and Febinger, Philadelphia. 1981. Argekar AP, Kunjir SS, Purandare KS: Simultaneous determination of rifampicin, isoniazid and pyrazinamide by high performance thin layer chromatography (Short communication). J Pharm Biomed Anal 1996, 14 : 1645-1650 Arnott S, Scott WE, Rees DA, McNab CGA: i-Carrageenan: Molecular structure and packing of polysaccharide double helices in oriented fibres of divalent cation salts . J Mol Biol 1974, 90 (2): 253-256. Arora S, Ali J, Ahuja A, Khar RK, Baboota S: Floating Drug Delivery Systems: A Review. AAPS PharmSciTech 2005, 6(3): E372-E390. Aulton ME (editor): Pharmaceutics: The Science of Dosage Form Design. Churchill Livingstone, Harcourt Publishers Ltd, UK. 2002. Aulton ME, Cole G, Hogan J: Pharmaceutical Coating Technology. Taylor and Francis, London, Brighton, Basingstoke, Abingdon, UK. 1995. Bakan JA: Microencapsulation. In: Lachman I, Lieberman HA, Kanig JL (Editors). The Theory and Practice of Industrial Pharmacy . 3 rd ed. Lea and Febiger, Philadelphia. 1986: 412-429. Bannister LH: Alimentary system. In: Williams PL (editor): Gray’s Anatomy, XXXVIII . Churchill Livingstone, New York, USA. 1995: 1683–1812. Barik BB, Gupta BK, Pal M: Preparation and evaluation of rifampicin microspheres. The Eastern Pharmacist 1993, 36 : 173–175. Barkai A, Pathak YV, Benita S: Polyacrylate (Eudragit Retard ®) microspheres for oral controlled release of Nifedipine. I. Formulation design and process optimization. Drug Dev Ind Pharm 1990, 16 : 2057–2075. Barrow EL, Winchester GA, Staas JK, Quenelle DC, Barrow WW: Use of microsphere technology for targeted delivery of rifampin to Mycobacterium tuberculosis -infected macrophages. Antimicrob Agents Chemother 1998 , 42 : 2682-2689. Bastian I, Portaels F: Multidrug resistant tuberculosis . Kluwer Academic Publishers, London, UK. 2000: 165. Beck LR, Cowsar DR, Lewis DH, Cosgrove RJ, Riddle CT, Lowry SL, Epperly T: A new long- acting injectable microcapsule system for the administration of progesterone. Fertil Steril 1979, 31 : 545–551. Bianchini R, Resciniti M, Vecchio C. Technology evaluation of aqueous enteric coating systems with and without insoluble additives. Drug Dev Ind Pharm 1991, 17 : 1779-1794. Blaser J, Konig C, Fatio R, Follath F, Cometta A, Glauser M: Multicenter quality control study of amikacin assay for monitoring once-daily dosing regimens. Ther Drug Monit 1995, 17 : 133–136. Blomberg B, Spinaci S, Fourie B, Laing R: The rationale for recommending fixed-dose combination tablets for treatment of tuberculosis. Bull WHO, 2001 , 79 : 61–79. Blomberg B, Fourie B: Fixed dose combination drugs for tuberculosis: Application in standardised treatment regimens. Drugs 2003, 63 (6): 535-553. Bodmeier R, Chen H: Preparation of biodegradable polylactide microspheres using spray-drying technique. J Pharm Pharmacol 1988, 40 : 754-757. Bodmeier R, Paeratakul O: Mechanical properties of dry and wet cellulosic and acrylic films prepared from aqueous colloidal polymer dispersions used in the coating of solid dosage forms. Pharm Res 1994, 11 (6): 882-888, Bodmeier R, Weng H, Hermann J: Microencapsulation of chlorpheniramine maleate, a drug with intermediate solubility properties by non-aqueous solvent evaporation technique. STP Pharm Sci 1994, 4: 275-281 Box GEP, Wilson KB: On the experimental attainment of optimum multifactorial conditions . Royal Statistics Society. 1951, 13 : 1–12. Box GEP, Hunter WG, Hunter JS: Statistics for Experimenters, An Introduction to Design, Data Analysis, and Model Building . Wiley, New York, USA. 1976. Brögmann B, Beckert TE: Enteric Targeting through Enteric Coating. In: Schreier H (editor): Drug Targeting Technology: Physical Chemical Biological Methods . Marcel Dekker, New York, NY, USA. 2001. Budavari S: The Merck Index: an encyclopedia of chemicals, drugs and biologicals . 11 th ed. Merck, Rahway, NJ. 1989. Buniva G, Pagani V, Carozzi A: Bioavailability of rifampicin capsules. Int J Clin Pharmacol Ther Toxicol 1983, 21 : 404-409. Carelli V, Di Colo G, Nannipieri E, Poli B, Serafini MF: Polyoxyethylene-poly(methacrylic acid- co-methyl methacrylate) compounds for site-specific peroral delivery. Int J Pharm 2000, 202 (1- 2): 103-112 Cavalieri SJ, Biehle JR, Sanders WE: Synergistic activities of clarithromycin and antituberculous drugs against multidrug-resistant Mycobacterium tuberculosis . Antimicrob Agents Chemother 1995, 39 : 1542-1545. CDER: Center for Drug Evaluation and Research. Dissolution Testing of Immediate Release Solid Dosage Forms, BP1, 1997. Chambers HF, Kocagoz T, Sipit T, Turner J, Hopewell PC: Activity of amoxicillin/clavulanate in patients with tuberculosis. Clin Infect Dis 1998 , 26 : 874-877. Chambers HF: Antimycobacterial drugs. In: Katzung BG (editor): Basic and Clinical Pharmacology. 8 th ed. McGraw-Hill, New York, NY, USA. 2001: 803-318. Chang CM, Bodmeier R: Organic solvent-free polymeric microspheres prepared from aqueous colloidal polymer dispersions by a w/o-emulsion technique. Int J Pharm 1996, 130 : 187-194. Chaplin M: Water Structure and Behaviour: The Hofmeister series. Updated 2006. Retrieved from: [http://www.lsbu.ac.uk/water/hofmeist.html ] on 21 June 2006. Chen Y-J: The solubility enhancement and the stability assessment of rifampicin, isoniazid and pyrazinamide in aqueous media. Master of Science Thesis . Rhodes University, South Africa, 2000. Chik J, Mizrahi S, Chi S, Parsegian VA, Rau DC: Hydration forces underlie the exclusion of salts and of neutral polar solutes from hydroxypropylcellulose. J Phys Chem B 2005, 109 (18): 9111 - 9118. Cohen S, Andrianov AK, Wheatley M, Allcock HR, Langer RS: Gas-filled polymeric microbubbles for ultrasound imaging. United States Patent No. 5 487 390. 1996. Cohen S: Microparticulate systems for the delivery of proteins and vaccines. Marcel Dekker, New York, NY, USA. 1996. Comstock GW, Livesay VT, Woolpert SF: The prognosis of a positive tuberculin reaction in childhood and adolescence. Am J Epidemiol 1974, 99 : 131–138. Coupe AJ, Davis SS, Wilding IR: Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects . Pharm Res 1991, 8(3): 360-364. Crooks PA, Cynkowski T, Cynkowska G, Guo H, Ashton, P: Permeable, water soluble, non- irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids. United States Patent 6 765 019. 2004. CSIR, Project: Background of Nano drug delivery. Nanoparticle drug delivery systems allow sustained antituberculosis