11-14 SEPTEMBER 2011 | MALTA ABSTRACT BOOK TABLE OF CONTENTS: ORAL PRESENTATIONS ORAL PRESENTATIONS SCIENTIFIC PROGRAMME PAGE PAGE SPA 1: CLINICAL IMPACT AND DIAGNOSTIC APPROACHES SPB 2: VIRUS-HOST INTERACTION / PATHOGENESIS / 2 A102O TRANSMISSION (2) Pulmonary pathology of pandemic influenza A/H1N1 virus 19 B201O (2009) infected ferrets upon longitudinal evaluation by computed The influenza virus protein pb1-f2 inhibits the induction of type 1 tomography interferon at the level of the mavs adaptor protein K. Stittelaar , E. Veldhuis Kroeze , G. van Amerongen , M. Dijkshoorn , J. Simon1, L. de Z.T. Varga , I. Ramos , R. Hai , M. Schmolke , A. Garcia-Sastre , A. Fernandez-Sesma , P. Waal , I. Hartmann , G. Krestin , T. Kuiken , A. Osterhaus Palese 3 A103O 20 B202O Seasonal influenza and acute myocardial infarction: a self- Why is HPAI H5N1 virus not transmissible via aerosol? An controlled case series study using UK primary care data extensive mutational and phenotypic analysis of mutant and C. Warren-Gash , A.C. Hayward , R. Pebody , H. Whitaker , L. Smeeth reassortant H5N1 viruses S. Herfst , E.J.A. Schrauwen , S. Chutinimitkul , E. de Wit , V.J. Munster , M. Linster , E.M. Sorrell , T.M. Bestebroer , G.F. Rimmelzwaan , A.D.M.E. Osterhaus , R.A.M. Fouchier SPB 1: VIRUS HOST INTERACTION / PATHOGENESIS / 21 B203O TRANSMISSION (1) Demographic and climatologic characteristics of human avian 4 B101O influenza (A/H5N1) Pandemic H1N1/09 in pigs: a reservoir host and model for human S.en.Z Zhou , L.sa. Ronald disease. 22 B204O S.M. Brookes , F. Garcon , A. Germundsson , R. Gardner , B. Nash , C.A. Donnelly , x. Cosi , The virulence of 1997 H5N1 influenza viruses in the mouse model I.H. Brown is increased by correcting a defect in their NS1 proteins 6 B102O R.M. Krug , A. Spesock , M. Malur , M.D.J. Hossain , L.M. Chen , B. Njaa , C.T. Davis , A.S. The effect of avian species on the transmissibility of highly Lipatov , I. York , R.O. Donis pathogenic avian influenza (HPAI) H5N1 virus: turkeys, chickens 23 B205O and ducks Human-like PB2 627K influenza virus polymerase activity is B.Z. Londt , S.M. Brookes , B.J. Nash , M.D. Kelly , J. McCauley , I.H. Brown regulated by importin-a1 and -a7 7 B103O B. Hudjetz , G. Gabriel Avian Influenza Virus Hemagglutinins H2, H4 and H8 support a highly pathogenic phenotype in chicken J. Stech , J. Veits , S. Weber , A. Breithaupt , J.P. Teifke , S. Gohrbandt , J. Bogs , M. Graeber , O. SPA 3: PANDEMIC AND EPIDEMICS Stech , T.C. Mettenleiter 24 A301O 8 B104O The pandemic is not over yet – influenza surveillance in Danish Pathogenesis of influenza A/H5N1 virus infection in ferrets differs intensive care units during the 2009/10 and 2010/11 influenza betweenintranasal and intratracheal routes of inoculation seasons J. Kreijtz , J.H.C.M. Kreijtz , G. van Amerongen , R.A.M. Fouchier , A.D.M.E. Osterhaus , G.F. S. Gubbels , T. Grove Krause , K. Mølbak , S. Glismann Rimmelzwaan , T. Kuiken 25 A302O Age-specific mortality and years of life lost associated with the A/ SPA 2: VACCINES: CURRENT AND NOVEL APPROACHES H1N1 influenza pandemic in Mexico, 2009-2010 D. Weinberger , C. Viboud , V. Charu , L.S. Palacio Mejia , S. Echevarría-Zuno , V.H. Borja 9 A201O Aburto , L. Simonsen , M.A. Miller , G. Chowell Plant-made influenza virus-like particles: an effective way of 27 A303O producing next generation vaccines Influenza in the Tropics: High Burden and Defined Seasonality in a N. Landry , B.J. Ward , L.P. Vézina Nicaraguan Pediatric Cohort 10 A202O A. Gordon , S. Saborio2, G. Kuan3, E. Videa4, R. Lopez2, A. Balmaseda2, E. Harris5 Development of a human cell-based Virus-Like Particle (VLP) 28 A304O Vaccine for Pandemic Influenza Incidence of Influenza in Healthy Adults and Healthcare Workers: B. Dropulic , L. Baranyi , K. Schonely , S. Roberts , K. Crowley , M. Son , A. Tsiomenko , R. Keefe , G. Robertson , V. Tsvetnitsky , R. Bright A Systematic Review and Meta-Analysis A. McGeer , S.P. Kuster , B. Coleman , P. Lam , A. Wormsbecker , P. Shah 11 A203O High-yield influenza vaccine production due to trypsin-mediated 29 A305O inhibition of interferon signaling Case-based reported mortality associated with influenza A(H1N1) T. Frensing , C. Seitz , B. Heynisch , U. Reichl 2009 virus infection in the Netherlands: pandemic versus first 12 A204O post-pandemic season. A.B. van Gageldonk-Lafeber , R.M. Riesmeijer , I.H.M. Friesema , A. Meijer , L.D. Isken , A. Improved haemagglutinin antigen content of pandemic H1N1v Timen , M.A.B. van der Sande candidate vaccine viruses with chimeric haemagglutinin molecules R. Harvey , K.A. Guilfoyle , S. Roseby , J.S. Robertson , O.G. Engelhardt SPB 3: VIRUS STRUCTURE & REPLICATION 13 A204P 30 B302O Vaccine R&D Development Success Rates Quantified; Interaction of the influenza A virus polymerase subunit PB1 with Considerations for Vaccine Investors the host nuclear import factor RanBP5 E.S. Pronker , T.C. Weenen , H. Commandeur , A.D.M.E. Osterhaus , H.J.H.M. Claassen E.C. Hutchinson , O.E. Orr , S.M. Liu , O.G. Engelhardt , E. Fodor 15 A208P 31 B303O Entrepreneurship in Vaccine Development A supramolecular assembly formed by influenza A virus genomic Pronker, E.S. *; Hulsink, W. ; Osterhaus, A.D.M.E. ; Claassen, H.J.H.M. ; RNA segments 17 A209P R. Marquet , E. Fournier , V. Moules , B. Essere , J.C. Paillart , J.D. Sirbat , C. Isel , A. Cavalier , Influenza Vaccines; Learning from Failure J.P. Rolland , D. Thomas , B. Lina E.S. Pronker , H. Commandeur , A.D.M.E. Osterhaus , H.J.H.M. Claassen B | THE FOURTH ESWI INFLUENZA CONFERENCE | 11-14 SEPTEMBER 2011 | MALTA TABLE OF CONTENTS:CONTENTS ORAL PRESENTATIONS PAGE PAGE SPA 4: ANTIVIRALS AND RESISTANCE SPB 5: GENETIC AND ANTIGENIC EVOLUTION 32 A401O 45 B501O Hemagglutinin activating host cell proteases provide promising 35 years of antigenic evolution of influenza A/H3N2 virus is drug targets for influenza treatment dictated by 7 amino acid positions flanking the hemagglutin E. Böttcher-Friebertshäuser , C. Freuer , F. Sielaff , C. Tarnow , D. Meyer , T. Steinmetzer , H.D. receptor binding site Klenk , W. Garten B.F. Koel , D.F. Burke , T.M. Bestebroer , S. Van der Vliet , G. Vervaet , E. Skepner , C.A. Russell , 33 A402O J.C. De Jong , A.D.M.E. Osterhaus , D.J. Smith , R.A.M. Fouchier Influenza virus and intracellular redox state: characterization of 46 B502O redox-sensitive molecular targets for innovative antiviral strategies Discordant antigenic drift of neuraminidase and hemagglutinin in A.T. Palamara , D. Amatore , R. Sgarbanti , K. Aquilano , M.R. Ciriolo , E. Garaci , L. Nencioni recent h1n1 and h3n2 influenza viruses 34 A403O K.B. Westgeest , M.R. Sandbulte , J. Gao , X. Xu , A.I. Klimov , C. Russell , D.J. Smith , M.C. Generation of (multi)drug-resistant influenza A/H1N1 (2009) Eichelberger , R.A.M. Fouchier viruses by reassortment 47 B503O B. Schweiger , J. Reichel , K. John , S.C. Duwe Estimating Reassortment Rates and Epistasis in Influenza viruses from European Swine S.J. Lycett , S. Bhatt , O.G. Pybus , G. Baillie , E. Coulter , P. Kellam , J.L.N. Wood , I.H. Brown , SPB 4: ECOLOGY AND EPIDEMIOLOGY OF ANIMAL INFLUENZA C.O.S.I. Consortium , A.J. Leigh Brown 35 B401O 48 B504O Spatial Dynamics of Human-origin H1 Influenza A Virus in North Neutralizing antibody epitopes on the hemagglutinin of recent American Swine H3N2 viruses M.I. Nelson , P. Lemey , Y. Tan , A. Vincent , T.T.Y. Lam , S. Detmer , C. Viboud , M.A. Suchard , G. Air , L. Popova , L. Venkatramani , K. Smith , P.C. Wilson , L.M. Thomas , B.H.M. Mooers , A. Rambaut , E.C. Holmes , M. Gramer J.A. James , L.F. Thompson 36 B402O 49 B505O Neutralizing antibodies against pandemic h1n1, seasonal h1n1 Comparative aspects of infectious salmon anaemia virus, a fish and avian-like h1n1 swine influenza virus in swine contacts and orthomyxovirus, and influenza viruses swine, Western-Europe T. Markussen , H. Sindre , D.H. Christiansen , M. Hjortaas , O.B. Dale , K. Falk C.P. Muller , N. Luetteke , N. Gerloff , J.R. Kremer , C.M. Olinger , P. Weicherding , K. Van Reeth 37 B403O SPA 6: VACCINE SAFETY Multiple introductions of h5n1 influenza viruses into lao people’s 50 A601O democratic republic Possible outcomes of reassortment in vivo between wild type and S. Sonnberg , P. Phommachanh , T.S. Naipospos , D. Darnell , C. Chanthavisouk , A. Rubrum , live attenuated influenza vaccine strains M. Souriya , B. Douangngeun , B. Khambounheuang , R. Webby , R. Webster I. Kiseleva , I. Dubrovina , E. Bazhenova , E. Fedorova , N. Larionova , L. Rudenko 38 B403O 51 A602O Molecular epidemiology of Highly Pathogenic Avian Influenza in Scientific investigations into febrile reactions observed in the Bangladesh paediatric population following vaccination with a 2010 Southern S.S.U. Ahmed , G.E. Themudo , J.P. Christensen , P.K. Biswas , M. Giasuddin , M.A. Samad , N. Hemisphere Trivalent Influenza Vaccine Toft , A.K. Ersbøll E. Maraskovsky , M. Barnden , A. Dyson , S. Koernig , A. Baz Morelli , S. Rockman , P. Schoofs , D. Hung , M. Greenberg , M. Pearse 52 A603O SPA 5: HOW TO EVALUATE VACCINE EFFECTIVENESS AND EFFICACY? Safety comparison of MF59-adjuvanted and non-adjuvanted 39 A501O seasonal influenza vaccines in 107,661 elderly subjects in Italy I-MOVE, a European network to monitor influenza vaccine M. Villa , S. Mannino , G. Apolone , I. Aquino , L. Boldori , F. Caramaschi , A. Gattinoni , G. effectiveness in the EU: Results from the multi-centre case control Malchiodi , A. Crucitti , N. Groth , G. Della Cioppa , S. Black studies, seasons 2008-9, 2009-10, 2010-11 53 A604O Savulescu, C., E. Kissling , B. Ciancio , on behalf of the I-MOVE multicentre case-control Annual vaccination against influenza hampers the development of study team infection-induced heterosubtypic immunity 40 A502O R.