STATE ESTABLISHMENT «DNIPROPETROVSK MEDICAL ACADEMY OF HEALTH MINISTRY OF UKRAINE» V.I. MAMCHUR, V.I. OPRYSHKO, А.А. NEFEDOV, A.E. LIEVYKH, E.V.KHOMIAK PHARMACOLOGY WORKBOOK FOR PRACTICAL CLASSES FOR FOREIGN STUDENTS STOMATOLOGY DEPARTMENT DNEPROPETROVSK - 2016 2 UDC: 378.180.6:61:615(075.5) Pharmacology. Workbook for practical classes for foreign stomatology students / V.Y. Mamchur, V.I. Opryshko, A.A. Nefedov. - Dnepropetrovsk, 2016. – 186 p. Reviewed by: N.I. Voloshchuk - MD, Professor of Pharmacology "Vinnitsa N.I. Pirogov National Medical University.‖ L.V. Savchenkova – Doctor of Medicine, Professor, Head of the Department of Clinical Pharmacology, State Establishment ―Lugansk state medical university‖ E.A. Podpletnyaya – Doctor of Pharmacy, Professor, Head of the Department of General and Clinical Pharmacy, State Establishment ―Dnipropetrovsk medical academy of Health Ministry of Ukraine‖ Approved and recommended for publication by the CMC of State Establishment ―Dnipropetrovsk medical academy of Health Ministry of Ukraine‖ (protocol №3 from 25.12.2012). The educational tutorial contains materials for practical classes and final module control on Pharmacology. The tutorial was prepared to improve self-learning of Pharmacology and optimization of practical classes. It contains questions for self-study for practical classes and final module control, prescription tasks, pharmacological terms that students must know in a particular topic, medical forms of main drugs, multiple choice questions (tests) for self- control, basic and additional references. This tutorial is also a student workbook that provides the entire scope of student’s work during Pharmacology course according to the credit-modular system. The tutorial was drawn up in accordance with the working program on Pharmacology approved by CMC of SE ―Dnipropetrovsk medical academy of Health Ministry of Ukraine‖ on the basis of the standard program on Pharmacology for stomatology students of III - IV levels of accreditation in the specialties Stomatology – 7.110105, Kiev 2011. The tutorial was developed by composite authors of the Department of Pharmacology, Clinical Pharmacology and Pharmacoeconomics of State Establishment ―Dnipropetrovsk medical academy of Health Ministry of Ukraine‖. © V.Y. Mamchur, V.I. Opryshko, A.A. Nefedov 2 3 V.I. MAMCHUR, V.I. OPRYSHKO, А.А. NEFEDOV PHARMACOLOGY WORKBOOK FOR PRACTICAL CLASSES FOR FOREIGN STUDENTS STOMATOLOGY DEPARTMENT Student___________________________________________________ Course_________Group_________________Decade______________ Faculty___________________________________________________ Teacher _________________________________________________ Academic year________ / __________ 3 4 № Module 1 Maximal grade topics General prescription. General pharmacology. Drugs affecting the synapses. Drugs affecting the peripheral and central nervous system Semantic unit № 1 General prescription 1. Ukrainian law «About medical drugs». Introduction into general prescription. 6 The solid dosage forms. 2. The soft dosage forms. 6 3. Liquid dosage forms. Solutions for intrernal and external use and for 6 injection, aerosoles. 4. Potions, decoctions, and solutions that dosed in drops and spoons. 6 5. The final lesson on general prescription. 6 Semantic unit № 2 History of Pharmacology and Pharmacy Common pharmacology 6. Introduction into pharmacology. Pharmacology and pharmacy development. 6 The final lesson on common pharmacology. Semantic unit № 3 Agents acting on the peripheral afferent and efferent nervous system 7. Local anesthetics, astringent, absorbent, irritating drugs. Mucos membrane 6 protectors. 8. M, N cholinomimetics, anticholinesterase agents. М-cholinoblockers. 6 N-cholinoblockers (ganglioniс blockers, neuromuscular blocking drugs) 9. Agents affecting on adrenoreceptors. Adrenomimetics drugs, 6 sympathomimetics. 10. Antiadrenergic drugs: adrenoblockers and, sympatholytics. 6 11. Dopaminergic, serotoninergic drugs. 6 The final lesson on agents acting on the peripheral afferent and efferent nervous system. Semantic unit №4 Drugs acting on the central nervouse system 12. Psychotropic drugs. Sedative drugs, neuroleptics, tranquilizers (Anxiolytics 6 drugs), mood stabilizers. 13. Hypnotics drugs, antiepileptic and antiparkinsonic drugs. 6 14. General anaesthetics. Pharmacology and toxicology of ethyl alcohol. 6 15. Narcotic (Opioid) analgesics 6 16. Non-narcotic (non-opioid) analgesics. Nonsteroidal anti-inflammatory drugs 6 17. Psychomotor stimulants. Analeptics. Antidepressants. Nootropic drugs. 6 Adaptogenes. Actoprotectors. 18. The final lesson on drugs acting on the central nervouse system. 6 4 5 № Module 2 Maxim al topics Pharmacology of medications that affect on function of the executive body’s grade systems, metabolism, blood and immune system. Pharmacology of antimicrobial, antiviral, antiparasitic and antifungal medications Semantic unit №5 Pharmacology of metabolism 1. Theme 16. Pharmacology of the endocrine system. Hormonal agents, their synthetic 6 substitutes and antagonists. 2. Theme 17. Pharmacology of vitamins. Enzyme preparations and their inhibitors. 6 3. Theme 18. Pharmacology of a blood system. Pharmacology of substances affecting 6 hematopoiesis. Medications affecting blood coagulation, platelet aggregation, and fibrinolysis. 4. Theme 19. Allergy and immunotropic medications. 6 The final lesson «Pharmacology of metabolism». Semantic unit №6 Pharmacology of Medications which affect the function of organs and physiological systems 5. Theme 20. Pharmacology of the respiratory system. 6 6. Theme 21. Pharmacology of the digestive system 6 7. Theme 22. Pharmacology circulation. Hypo-and hypertensive agents. 6 Antihyperlipidemic agents. Angioprotectors. 8. Theme 23. Pharmacology of the coronary and cerebral blood flow. Antianginal and 6 cerebrovascular medications 9. Theme 24. Cardiotonic medications.Antiarrhythmic medications 6 10. Theme 25. Pharmacology of agents affecting water and electrolyte balance. 6 Arthrifuge. 11. Theme 26. Uterine medications and contraceptives. 6 Test control «Pharmacology of medications which affect the function of organs and physiological systems». 12. The final lesson «Pharmacology of medications which affect the function of 6 organs and physiological systems». Semantic unit 7 Pharmacology of antimicrobial, antiviral, antiparasitic, antifungal Medications 13. Theme 27. Antiseptics and disinfectants. Sulfonamides. Fluoroquinolones. 6 14. Theme 28. Antibiotics I (β - lactams, macrolides, aminoglycosides). 6 15. Theme 29. Antibiotics II (tetracyclines, chloramphenicol). Anti-fungal, anti- 6 viral, antitubercular medications. 16. Theme 30. Antiparasitic, anti-cancer medications. 6 The final lesson «Pharmacology of antimicrobial, antiviral, antiparasitic, antifungal medications». 17. Drugs affecting the mucous membranes of the mouth and tooth tissue. 18. Pharmacology of acute poisoning. Pharmacovigilance for side effects of medications.The final test control Module-2. 19. The final control Module-2. «Pharmacology of medications which 80 affect the function of the executive bodies, metabolism, blood system and immune system.Pharmacology of antimicrobial, antiviral, antiparasitic and antifungal Medications» Together semantic units 112 Student individual self-study (ISS) 8 Total 200 5 6 Note: After getting the traditional marks the student receives the following points. Practical classes: «5» – 6 «4» – 4 «3» – 3 «2» – 0 Final classes: «5» – 6 «4» – 4 «3» – 3 «2» – 0 Requirements for admittance to the final module control: routine academic performance with a minimal sum of grades 51 points in every semester passing the final test control with a result more than 75% 6 7 PLAN OF LECTURES (First semester) №№ LECTURE’S TOPICS History of the pharmocology development. Modern pharmacology 1. condition. Ukrainian law «About medical drugs». General pharmacology. Agents acting on the peripheral efferent nervous system. M, N cholinomimetics, anticholinesterase agents. М-cholinoblockers. N-cholinoblockers (ganglioniс blockers, neuromuscular blocking drugs) 2. Agents affecting on adrenoreceptors. Adrenomimetics drugs, sympathomimetics. Antiadrenergic drugs: adrenoblockers and, sympatholytics. Psychotropic drugs. Sedative drugs, neuroleptics, tranquilizers (Anxiolytics 3. drugs), mood stabilizers, salts of lithium. Hypnotics drugs, antiepileptic and antiparkinsonic drugs. Clinical use. Pharmacology of paid and anesthetics. General anesthetcs. 4. Classification of analgesics. Narcotic analgesics. Non-narcotic (non- opioid) analgesics. Nonsteroidal anti-inflammatory drugs. Pharmacology of drugs affecting the respiratory and digestive 5. system. 7 8 PLAN OF LECTURES (Second semester) №№ LECTURE’S TOPICS Pharmacology of the respiratory system: decongestants, expectorant, antitussive and bronchodilators. 1 Pharmacology of the digestive system. Medications affecting motor and secretory activity of the stomach and intestines. Hepatotropic and pankreatotropnye medications. Pharmacology of systemic, coronary and cerebral circulation. Antihypertensive, antianginal and cerebro-vesselactive medications. 2 Pharmacology of heart failure. Cardiac medications of glycoside and aglycoside nature. Antiarrhythmic medications. Pharmacology of antimicrobial agents (AA). Antiseptics and disinfectants. Synthetic AA: sulfonamides, derivatives nitroimidazole quinoxaline. 3 General principles of rational antibiotic therapy. Pharmacology of β-lactam antibiotics. Aminoglycosides. Macrolides. Chloramphenicol and tetracycline.