ONLINE SUPPLEMENT Effect of Cosyntropin during Adrenal Venous Sampling on Subtype of Primary Aldosteronism: Analysis of Surgical Outcome Hiroki Kobayashi, MD, PhD1, 2, 3; Yoshihiro Nakamura, MD1; Masanori Abe, MD, PhD1; Isao Kurihara, MD, PhD4; Hiroshi Itoh, MD, PhD4; Takamasa Ichijo, MD, PhD5; Yoshiyu Takeda, MD, PhD6; Takashi Yoneda, MD, PhD6; Takuyuki Katabami, MD, PhD7; Mika Tsuiki, MD, PhD8; Norio Wada, MD, PhD9; Yoshihiro Ogawa, MD, PhD10; Ryuichi Sakamoto, MD, PhD10; Junji Kawashima, MD, PhD11; Masakatsu Sone, MD, PhD12; Nobuya Inagaki, MD, PhD12; Takanobu Yoshimoto, MD, PhD13, 14; Tetsuya Yamada, MD, PhD14; Ryuji Okamoto, MD, PhD15; Yuichi Matsuda, MD, PhD16; Megumi Fujita, MD, PhD17; Minemori Watanabe, MD, PhD18; Kouichi Tamura, MD, PhD19; Akiyo Tanabe, MD, PhD20; Mitsuhide Naruse, MD, PhD8; JPAS/JRAS Study Group 1Division of Nephrology, Hypertension, and Endocrinology, Nihon University School of Medicine, Tokyo, Japan 2Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, Boston, MA, USA 3Department of Medicine, Harvard Medical School, Boston, MA, USA 4Department of Endocrinology, Metabolism, and Nephrology, Keio University School of Medicine, Tokyo, Japan 5Department of Diabetes and Endocrinology, Saiseikai Yokohamashi Tobu Hospital, Yokohama, Japan 6Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan 7Division of Metabolism and Endocrinology, Department of Internal Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital, Yokohama, Japan 8Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan 9Department of Diabetes and Endocrinology, Sapporo City General Hospital, Sapporo, Japan 10Department of Medicine and Bioregulatory Science, Kyushu University, Fukuoka, Japan 11Department of Metabolic Medicine, Faculty of Life Science, Kumamoto University, Kumamoto, Japan 12Department of Diabetes, Endocrinology, and Nutrition, Kyoto University, Kyoto, Japan 13Department of Diabetes and Enodocrinology, Tokyo Metropolitan Hiroo Hospital, Tokyo, Japan 14Department of Molecular Endocrinology and Metabolism, Tokyo Medical and Dental University, Tokyo, Japan 1 15Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan 16Department of Cardiology, Sanda City Hospital, Sanda, Japan 17Division of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan 18Department of Endocrinology and Diabetes, Okazaki City Hospital, Okazaki, Japan 19Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan 20Division of Endocrinology, National Center for Global Health and Medicine, Tokyo, Japan Short title: Effect of ACTH stimulation during AVS for PA outcome Corresponding Author: Hiroki Kobayashi, MD, PhD Division of Nephrology, Hypertension, and Endocrinology Department of Internal Medicine, Nihon University School of Medicine 30-1 Oyaguchi Kami-chou, Itabashi-ku, Tokyo 173-8610, Japan Tel.: +81-3-3972-8111 Fax: +81-3-3972-8311 E-mail: [email protected] Masanori Abe, MD, PhD Division of Nephrology, Hypertension, and Endocrinology Department of Internal Medicine, Nihon University School of Medicine 30-1 Oyaguchi Kami-chou, Itabashi-ku, Tokyo 173-8610, Japan Tel.: +81-3-3972-8111 Fax: +81-3-3972-8311 E-mail: [email protected] Acknowledgment The acknowledgement list of the JPAS/JRAS Group. Abe, Masanori Division of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine: Asano, Mai Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine: Chiba, Yoshiro Department of Cardiology, Mito Saiseikai General Hospital: Fujii, Yuichi Department of Cardiology, Medical Corporation JR Hiroshima Hospital: Fujita, Megumi Division of Nephrology and Endocrinology, University of Tokyo School of Medicine: Fukuda, Hisashi Division of Metabolism and Endocrinology, St. Marianna University School of Medicine: Fukui, Michiaki Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine Fukuoka, Tomikazu Department of Internal Medicine, Matsuyama Red Cross Hospital: Goto, Hiromasa Department of Medicine, Metabolism and Endocrinology, Juntendo University Graduate School of Medicine: Haji, Tatsuya Division of nephrology and hypertension, Yokohama City University Medical Center: Hasegawa, Tomonobu Department of Pediatrics, Keio University School of Medicine: Hashimoto, Shigeatsu Department of Metabolism, Diabetes and 2 Nephrology, Fukushima Medical University Aizu Medical Center: Ichijo, Takamasa Department of Endocrinology and Metabolism, Saiseikai Yokohamashi Tobu Hospital: Inagaki, Nobuya Department of Diabetes, Endocrinology and Nutrition, Kyoto University: Itoh, Hiroshi Division of Endocrinology, Metabolism and Nephrology, Keio University School of Medicine: Iwamoto, Tamio Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine: Izawa, Shoichiro Department of Endocrinology and Metabolism, Tottori University Hospital: Kai, Tatsuya Department of Internal Medicine, Sakurakai Hospital: Kakutani, Miki Department of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine: Kamemura, Kouhei Department of Cardiology, Akashi Medical Center: Katabami, Takuyuki Division of Metabolism and Endocrinology, St. Marianna University School of Medicine: Kawaguchi, Takahisa Agency for Health, Safety and Environment, Kyoto University: Kawamura, Takashi Kyoto University Health Services: Kawashima, Junji Department of Metabolic Medicine, Faculty of Life Science, Kumamoto University: Kimura, Noriko Department of Pathology, National Hospital Organization, Hakodate Hospital: Kobayashi, Hiroki Division of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine: Kobayashi, Yusuke Department of Nephrology and Hypertension, Onshi Zaidan Saiseikai Southern Yokohama Hospital: Kometani, Mitsuhiro Division of Cardiovascular and Internal Medicine, Kanazawa University: Koyama, Hidenori Department of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine: Kurihara, Isao Division of Endocrinology, Metabolism and Nephrology, Keio University School of Medicine: Matsuda, Fumihiko Center for Genomic Medicine, Kyoto University: Matsuda, Yuichi Department of Cardiology, Sanda City Hospital: Miyauchi, Shouzou Department of Diabetes and Endocrinology, Ehime Prefectural Central Hospital: Miyazaki, Yasushi Department of Endocrinology and Diabetes, Misato Kenwa Hospital: Morisaki, Mitsuha Division of Endocrinology, Metabolism and Nephrology, Keio University School of Medicine: Nakamura, Toshifumi Division of Endocrinology, Metabolism and Nephrology, Keio University School of Medicine: Naruse, Mitsuhide National Hospital Organization Kyoto Medical Center, and Center of Endocrine Diseases, Takeda General Hospital: Nishimoto, Koshiro Department of Urologic Oncology, Saitama Medical University International Medical Center: Ogasawara, Tatsuki National Hospital Organization Kyoto Medical Center: Ogawa, Osamu Department of Urology, Kyoto University: Ogawa, Yoshihiro Department of Medicine and Bioregulatory Science, Kyushu University: Ogo, Atsushi National Hospital Organization Kyushu Medical Center: Ohno, Youichi Department of Diabetes, Endocrinology and Nutrition, Kyoto University: Okamoto, Ryuji Department of Cardiology and Nephrology, Mie University: Okamura, Shintaro Department of Endocrinology, Tenriyorozu Hospital: Okumura, Ataru Department of Endocrinology and Diabetes, Tokai Central Hospital: Oshima, Yosuke Division of Endocrinology, Metabolism and Nephrology, Keio University School of Medicine: Otshuki, 3 Michio Department of Metabolic Medicine, Osaka University Graduate School of Medicine: Rakugi, Hiromi Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine: Sakamoto, Ryuichi Department of Diabetes and Endocrinology, Saiseikai Fukuoka General Hospital: Shibata, Hirotaka Department of Endocrinology, Metabolism, Rheumatology and Nephrology, Oita University: Shibayama, Yui Department of Diabetes and Endocrinology, Sapporo City General Hospital: Shinbo, Takurou School of Medicine, International University of Health and Welfare: Soma, Masayoshi Division of General Medicine, Department of Internal Medicine, Nihon University School of Medicine: Sone, Masakatsu Department of Diabetes, Endocrinology and Nutrition, Kyoto University: Sugiyama, Toru Department of Endocrinology and Metabolism, Red Cross Musashino Hospital: Suzuki, Atsushi Department of Endocrinology and Metabolism, Fujita Health University: Suzuki, Tomoko Department of Public Health, School of Medicine, International University of Health and Welfare: Takahashi, Katsutoshi Division of Nephrology and Endocrinology, University of Tokyo School of Medicine: Takahata, Sho Division of Endocrinology, Metabolism and Nephrology, Keio University School of Medicine: Takeda, Yoshihiro Division of Cardiovascular and Internal Medicine, Kanazawa University: Takeda, Yoshiyu Department of Internal Medicine, Kanazawa University: Takura, Tomoyuki Department of Healthcare economics and Health policy, University of Tokyo School of Medicine: Tamura, Koichi Department of Internal Medicine and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine: Tanabe, Akiyo National Center for Global Health and Medicine: Tanabe, Makito Department of Endocrinology and Diabetes Mellitus,