Singleton, Kim, Hinz, Marek, Casas-Selves, Hatheway, Tan, DeGregori and Heasley. A Receptor Tyrosine Kinase Network Comprised of FGFRs, EGFR, ERBB2 and MET Drives Growth and Survival of Head and Neck Squamous Carcinoma Cell Lines. MOLPHARM #084111 SUPPLEMENTAL TABLE 1: List of shRNAs used for validation. Singleton, Kim, Hinz, Marek, Casas-Selves, Hatheway, Tan, DeGregori and Heasley. A Receptor Tyrosine Kinase Network Comprised of FGFRs, EGFR, ERBB2 and MET Drives Growth and Survival of Head and Neck Squamous Carcinoma Cell Lines. MOLPHARM #084111 SUPPLEMENTAL TABLE 2: SLATs (E-value cut off of E value ≤2) in UMSCC25, 584-A2, and CCL30. UMSCC25 Rank Gene Symbol p-value [p(wZ)] E value Rank Gene Symbol p-value [p(wZ)] E value 1 CLUAP1 5.15E-07 5.15E-07 48 FHL1 4.84E-04 2.32E-02 2 ZFR 8.78E-07 1.76E-06 49 RABGGTB 5.03E-04 2.46E-02 3 MET 1.94E-06 5.83E-06 50 THPO 5.28E-04 2.64E-02 4 MEMO1 1.95E-06 7.79E-06 50 BCAP29 5.28E-04 2.64E-02 5 NPAT 3.00E-06 1.50E-05 52 KBTBD4 5.28E-04 2.75E-02 6 EPB41L4B 3.18E-06 1.91E-05 53 MEX3B 5.28E-04 2.80E-02 7 G2E3 3.43E-06 2.40E-05 54 EML4 5.29E-04 2.85E-02 8 PSMD13 4.10E-06 3.28E-05 55 C20orf7 5.29E-04 2.91E-02 9 MUC7 5.60E-06 5.04E-05 56 GPR126 5.29E-04 2.96E-02 10 ARSD 5.67E-06 5.67E-05 56 PNPO 5.29E-04 2.96E-02 11 TMEM163 1.13E-05 1.24E-04 58 TJAP1 5.29E-04 3.07E-02 12 PCTK2 1.38E-05 1.65E-04 58 SLC26A2 5.29E-04 3.07E-02 13 ANP32E 1.38E-05 1.80E-04 58 NETO2 5.29E-04 3.07E-02 14 ITGA6 2.62E-05 3.66E-04 61 MAML3 5.29E-04 3.23E-02 15 C14orf147 2.74E-05 4.11E-04 62 HLA-DRB3 5.30E-04 3.29E-02 16 MDH1B 3.18E-05 5.08E-04 62 HLA-DRB1 5.30E-04 3.29E-02 17 SP1 3.68E-05 6.25E-04 62 HLA-DRB5 5.30E-04 3.29E-02 18 ALDOB 4.96E-05 8.92E-04 62 SPRYD5 5.30E-04 3.29E-02 19 ANAPC5 5.12E-05 9.72E-04 66 SYT14L 5.30E-04 3.50E-02 20 FCGR3B 5.17E-05 1.03E-03 67 DGAT2 5.31E-04 3.56E-02 21 TBXA2R 5.39E-05 1.13E-03 68 ZNF10 5.32E-04 3.62E-02 22 MT1X 5.80E-05 1.28E-03 69 ZNF764 5.32E-04 3.67E-02 23 SCRN3 6.54E-05 1.51E-03 70 E4F1 5.32E-04 3.73E-02 24 PAPOLA 7.53E-05 1.81E-03 70 NOV 5.32E-04 3.73E-02 25 FGFR1OP2 7.54E-05 1.88E-03 70 SSBP3 5.32E-04 3.73E-02 26 KCTD14 1.06E-04 2.75E-03 73 COL6A1 5.33E-04 3.89E-02 27 LLGL2 1.39E-04 3.76E-03 74 PLEKHA6 5.33E-04 3.94E-02 28 PYGM 1.45E-04 4.06E-03 75 TMEM196 5.33E-04 4.00E-02 29 MFI2 1.52E-04 4.40E-03 76 DCN 5.33E-04 4.05E-02 30 FAM136A 1.67E-04 5.02E-03 77 ZNF280B 5.34E-04 4.11E-02 31 ZNF787 1.68E-04 5.22E-03 78 PDCD11 5.34E-04 4.17E-02 32 FPR2 1.89E-04 6.04E-03 79 CXADR 5.35E-04 4.22E-02 33 TMED5 2.07E-04 6.83E-03 79 HLA-G 5.35E-04 4.22E-02 34 PTP4A1 2.10E-04 7.16E-03 81 RUNX2 5.35E-04 4.33E-02 35 LSM4 2.16E-04 7.57E-03 82 ERBB2 5.35E-04 4.39E-02 36 FARSA 2.26E-04 8.13E-03 82 TRIB2 5.35E-04 4.39E-02 37 AGRN 2.37E-04 8.76E-03 84 C12orf48 5.36E-04 4.50E-02 38 FAM172A 2.52E-04 9.58E-03 85 MAST1 5.37E-04 4.56E-02 39 PTPN11 2.58E-04 1.01E-02 86 THAP10 5.37E-04 4.62E-02 40 TBX5 2.74E-04 1.10E-02 87 BCL11A 5.38E-04 4.68E-02 41 MBD6 3.55E-04 1.46E-02 88 CCDC88A 5.38E-04 4.74E-02 42 TRAM1 3.99E-04 1.68E-02 89 MARS2 5.39E-04 4.80E-02 43 VEGFA 4.12E-04 1.77E-02 90 C3AR1 5.40E-04 4.86E-02 44 ZNF79 4.13E-04 1.82E-02 91 KIAA0892 5.41E-04 4.92E-02 45 SCOC 4.14E-04 1.86E-02 92 POLD3 5.41E-04 4.98E-02 46 SEMA4D 4.42E-04 2.03E-02 93 C2orf52 5.44E-04 5.06E-02 47 CALM1 4.44E-04 2.09E-02 94 FSTL5 5.44E-04 5.12E-02 Singleton, Kim, Hinz, Marek, Casas-Selves, Hatheway, Tan, DeGregori and Heasley. A Receptor Tyrosine Kinase Network Comprised of FGFRs, EGFR, ERBB2 and MET Drives Growth and Survival of Head and Neck Squamous Carcinoma Cell Lines. MOLPHARM #084111 UMSCC25 Rank Gene Symbol p-value [p(wZ)] E value Rank Gene Symbol p-value [p(wZ)] E value 94 ZNF511 5.44E-04 5.12E-02 142 PLEKHO1 5.79E-04 8.22E-02 94 CD55 5.44E-04 5.12E-02 143 ZFP64 5.83E-04 8.33E-02 94 ST5 5.44E-04 5.12E-02 144 RPL28 5.83E-04 8.39E-02 94 NYX 5.44E-04 5.12E-02 145 C5orf45 5.86E-04 8.50E-02 99 FLJ22662 5.45E-04 5.39E-02 145 SQSTM1 5.86E-04 8.50E-02 100 BCAS2 5.46E-04 5.46E-02 147 COL5A3 5.88E-04 8.65E-02 100 FRAT2 5.46E-04 5.46E-02 148 CDV3 5.92E-04 8.76E-02 102 MAP7 5.46E-04 5.57E-02 148 SF3B14 5.92E-04 8.76E-02 103 KRT222P 5.46E-04 5.63E-02 150 HGD 5.95E-04 8.92E-02 104 AGPAT9 5.46E-04 5.68E-02 150 NIACR2 5.95E-04 8.92E-02 105 FAT2 5.46E-04 5.74E-02 150 RNF20 5.95E-04 8.92E-02 106 ITIH5 5.46E-04 5.79E-02 153 VWA5A 5.97E-04 9.13E-02 106 RAB3IP 5.46E-04 5.79E-02 153 PNPLA8 5.97E-04 9.13E-02 108 CYP2A7 5.48E-04 5.91E-02 155 FOXN3 6.00E-04 9.30E-02 109 FBXO31 5.48E-04 5.98E-02 156 LFNG 6.00E-04 9.37E-02 109 JCLN 5.48E-04 5.98E-02 157 PRKAB2 6.01E-04 9.44E-02 109 RPL24 5.48E-04 5.98E-02 158 CISH 6.07E-04 9.59E-02 112 MLH3 5.52E-04 6.18E-02 159 ACOX3 6.08E-04 9.66E-02 113 TGOLN2 5.53E-04 6.25E-02 159 FSCN3 6.08E-04 9.66E-02 114 C21orf62 5.54E-04 6.31E-02 161 PIP4K2C 6.09E-04 9.80E-02 115 ZNF407 5.55E-04 6.38E-02 162 SORBS2 6.11E-04 9.89E-02 116 KIR2DL1 5.56E-04 6.45E-02 162 SKP2 6.11E-04 9.89E-02 116 GTF2I 5.56E-04 6.45E-02 164 MGLL 6.11E-04 0.1003 116 KIR2DL2 5.56E-04 6.45E-02 165 CEACAM7 6.12E-04 0.1010 119 ARL6IP5 5.57E-04 6.63E-02 166 GNB4 6.12E-04 0.1016 120 YAF2 5.57E-04 6.69E-02 167 COL5A2 6.12E-04 0.1023 121 RSF1 5.59E-04 6.76E-02 168 PHB2 6.15E-04 0.1033 122 MMP14 5.63E-04 6.87E-02 169 PTBP2 6.16E-04 0.1041 123 PPAP2B 5.64E-04 6.94E-02 170 DCUN1D1 6.17E-04 0.1048 123 BCOR 5.64E-04 6.94E-02 170 OSTM1 6.17E-04 0.1048 125 ABTB2 5.65E-04 7.06E-02 172 CLCN7 6.17E-04 0.1061 125 OGFR 5.65E-04 7.06E-02 173 PTP4A2 6.21E-04 0.1075 127 TMPO 5.67E-04 7.20E-02 173 TACR2 6.21E-04 0.1075 128 FASTKD1 5.70E-04 7.30E-02 173 WWC2 6.21E-04 0.1075 129 DOK7 5.71E-04 7.36E-02 176 GNRHR 6.26E-04 0.1101 130 TRIOBP 5.71E-04 7.42E-02 176 PCDHB5 6.26E-04 0.1101 130 PDE1A 5.71E-04 7.42E-02 178 CBX3 6.26E-04 0.1114 132 TRAM2 5.71E-04 7.54E-02 179 PDS5A 6.30E-04 0.1127 133 THAP11 5.72E-04 7.61E-02 180 FAM62B 6.34E-04 0.1141 134 CNOT6L 5.74E-04 7.69E-02 180 CRYAA 6.34E-04 0.1141 134 TEX2 5.74E-04 7.69E-02 182 TRIM27 6.36E-04 0.1157 136 SEPT6 5.75E-04 7.82E-02 183 MLXIP 6.36E-04 0.1165 137 HSP90B1 5.76E-04 7.90E-02 184 HRASLS 6.40E-04 0.1178 138 HNRNPR 5.76E-04 7.96E-02 185 AVL9 6.40E-04 0.1185 138 PITPNM2 5.76E-04 7.96E-02 185 IGF2BP3 6.40E-04 0.1185 140 NFIB 5.77E-04 8.08E-02 187 CSNK1G2 6.42E-04 0.1200 141 SYT14 5.78E-04 8.16E-02 188 EPO 6.47E-04 0.1216 Singleton, Kim, Hinz, Marek, Casas-Selves, Hatheway, Tan, DeGregori and Heasley.