ABCD springer.com Just Released New Books All Titles, All Languages Sorted by author and title within the main subject springer.com Arts 2 Arts Biomedicine G. Bauer, J.S. Anderson Gene Therapy for HIV L. Unterseher D. Bar-Shalom, K. Rose (Eds.) From Inception to a Possible Cure This Brief describes the concept and realization Der Erste Weltkrieg Pediatric Formulations of gene therapy for HIV from the unique historic Trauma des 20. Jahrhunderts A Roadmap perspective and insight of two pioneers of the clinical applications of stem cell gene therapy for Bis in den Krieg hinein waren die Machteliten Until the 1990s, it was generally accepted that med- HIV.Gerhard Bauer applied ribozyme-anti-HIV Europas Getriebene: motiviert durch chauvinis- icines were first developed for adults and their use and other vectors to manufacture clinical grade, tische Ansprüche, Angriffsgeist und Hoffnungen in children was investigated later, if at all. One of HIV-resistant hematopoietic stem cells for the first auf raschen Sieg. Wohl sind in dieser Studie die ins the main tasks of hospital pharmacies was the man- patients that received stem cell gene therapy for Desaster führenden Tendenzen klar bezeichnet, doch ufacturing of child-appropriate formulations in a HIV, including the first child in the world and the wird darauf verzichtet, aus der Ursachenforschung more or less makeshift way. The first change came first fully marrow-ablated HIV infected patient. einen Gerichtsprozess zu machen. So steht denn das in 1997 with U.S. legislation that rewarded manu- Joseph Anderson developed the most recent and traumatisierende Geschehen selbst im Brennpunkt – facturers to do voluntary pediatric research. Ten most potent combination anti-HIV lentiviral vectors mit seinen Schauplätzen und Entwicklungen. Vom years later, the European Union passed legislation and pluripotent stem cell applications for HIV gene Grabenkampf, dem Patt defensiven Feuers, hin that required manufacturers to discuss all pediatric therapy and tested these in the appropriate in[...] zur Geburt eines neuen Bewegungskrieges – vom aspects, including formulations, with the regulatory Bankrott des Krieges bis zur Wiederbelebung. Und authorities as a condition of starting the registration Features es werden auch die Folgen des Gemetzels beleuchtet: procedure. In consequence, manufacturers must now This Brief describes the concept and realization Zum einen die Wirkungen auf die menschliche Seele, cover all age groups,[...] of gene therapy for HIV from the unique historic wie sie[...] perspective and insight of two pioneers of the Features clinical applications of stem cell gene therapy for Features As the first book that specifically addresses pediatric HIV.Gerhard Bauer applied ribozyme-anti-HIV Bis in den Krieg hinein waren die Machteliten formulations in the context of drug development, and other vectors to manufacture clinical grade, Europas Getriebene: motiviert durch chauvinis- Pediatric Formulations: A Roadmap covers anatomy HIV-resistant hematopoietic stem cells for the first tische Ansprüche, Angriffsgeist und Hoffnungen and physiology of children as well as the technical patients that received stem cell gene therapy for HIV, auf raschen Sieg. Wohl sind in dieser Studie die ins state of the art, gives hints about where to find inspi- [..] Desaster führenden Tendenzen klar bezeichnet, doch ration, and provides a suitable background on the wird darauf verzichtet, aus der Ursachenforschung regulatory framework. Existing books on pediatric Contents einen Gerichtsprozess zu machen. So steht denn das formulations mainly discuss compounding at [..] Principles of Gene Therapy.- Injection of Naked traumatisierende Geschehen selbst im Brennpunkt – DNA.- Non-Viral Gene Transfer (Transfection) mit seinen [..] Contents Methods.- Viral gene transfer (transduction) meth- Pediatric Development: Anatomy.- Age, Weight, ods.- Retroviruses.- Other viruses.- History of Gene Contents Body Surface and Stature, Organ Development.- Therapy.- Principles of HIV Gene Therapy.- Gene Statt einer Einleitung: Die sich selbst erfüllende Pediatric Development: Physiology. Enzymes, Drug Therapy Vectors.- Lentiviral vectors.- Other mod- Prophezeiung.- Vor dem Krieg: Mächte und Metabolism, Pharmacokinetics and Pharmacody- ifications and additions.- Anti-HIV genes.- RNA- Machenschaften.- Wichtige Schauplätze: Ein namics.- Pediatric Development – Gastrointestinal.- strategies.- Vector production.- Stem Cells for HIV Überblick.- Technik, Taktik, Kriegsbild: Sieg der How to Estimate the Dose to be Given for the First Gene Therapy.- Pluripotent stem cells.- Animal Defensive.- Perspektive: Wege zur Rettung des Time to Pediatric Patients.- The Clinical Relevance Models Used in HIV Gene Therapy.- Murine Krieges.- Materialschlacht: Wirkung auf Seele und of Pediatric Formulations.- General Considerations models.- HIV infections in humanized mice.- Non- Geist.- Nachwirkungen: Neuzuschnitt der Welt. for Pediatric Oral Drug Formulation.- Orosensory human primates.- Manufacturing of a GMP grade Perception.- Flavor Is Not Just Taste: Taste Conceal- product for HIV gene[...] Fields of interest ing.- Liquid Formulations.- Paediatric Solid Formu- History lations.- Semi-Solid Formulations.- The Challenge Fields of interest of[...] Gene Therapy; Virology; Immunology; Vaccine Target groups Popular/general Fields of interest Target groups Pharmaceutical Sciences / Technology; Pharmacy; Research Type of publication Pediatrics Monograph Type of publication Brief More on www.springer.com/978-3-658-05043-6 Target groups Research More on www.springer.com/978-1-4939-0433-4 Softcover Softcover 2014. XII, 119 S. Type of publication 2014. VIII, 72 p. 3 illus. in color. (SpringerBriefs in Bio- 16,81 € Contributed volume ISBN 978-3-658-05043-6 chemistry and Molecular Biology) More on www.springer.com/978-1-4899-8010-6 usually dispatched within 3 to 5 business days 49,99 € Hardcover ISBN 978-1-4939-0433-4 2014. XV, 439 p. 76 illus., 36 illus. in color. (AAPS usually dispatched within 3 to 5 business days Advances in the Pharmaceutical Sciences Series, Vol. 11) 139,99 € ISBN 978-1-4899-8010-6 usually dispatched within 3 to 5 business days springer.com Biomedicine 3 D. Edgell (Ed.) P. Eggleton, F.J. Ward (Eds.) A.A. Farooqui Homing Endonucleases Systemic Lupus Erythematosus Inflammation and Oxidative Stress Methods and Protocols Methods and Protocols in Neurological Disorders Homing Endonucleases: Methods and Protocols Systemic Lupus Erythematosus: Methods and Pro- Effect of Lifestyle, Genes, and Age aims at providing molecular biologists with a com- tocols describe a number of genetic, biochemical Unless new discoveries are made in the prevention prehensive resource to identify and characterize and immunological techniques. These techniques or treatment of stroke, Alzheimer's Disease and homing endonucleases from genomic sequence, to provide an advancing understanding of the pathol- depression, the number of patients with these dis- deduce the biological basis of binding and cleavage ogy, breakdown of the immune system and thera- eases is sure to increase dramatically by the year specificity, as well as to provide protocols to redesign peutic challenges of SLE in both humans and animal 2050. Thus, developing strategies to retard or delay endonuclease target specificity for genome-edit- models. Written in the highly successful Meth- the onset of stroke, AD and depression these neuro- ing applications. Engineering of designer homing ods in Molecular Biology series format, chapters logical disorders is of critical important. The present endonucleases has set the stage for genome editing include introductions to their respective topics, lists monograph will provide current and comprehen- of complex eukaryotic genomes with a broad range of the necessary materials and reagents, step-by- sive information on the relationship between neu- of potential applications including targeted gene step, readily reproducible laboratory protocols and roinflammation and oxidative stress in age-related knockouts in model organisms and gene therapy in key tips on troubleshooting and avoiding known neurological disorders at the molecular level. The humans, making this book a valuable resource for pitfalls.Authoritative and practical, Systemic Lupus information described in this monograph on lifestyle future research. Written in the highly successful[...] Erythematosus: Methods and Protocols appeal to (diet and exercise), genes and age is intended to facil- biomedical[...] Features itate and promote new discoveries[...] Homing Endonucleases: Methods and Protocols Features Features aims at providing molecular biologists with a com- Systemic Lupus Erythematosus: Methods and Proto- Consumption of healthy balanced diet (colored and prehensive resource to identify and characterize cols describes a number of genetic, biochemical and green vegetables, fresh fruits, lean meats, fish, and homing endonucleases from genomic sequence, to immunological techniques. These techniques pro- whole grain) along with moderate exercise (30-45 deduce the biological basis of binding and cleavage vide an advancing understanding of the pathology, min/day), and 6-7 hours of sleep results in a health- specificity, as well as to provide protocols to redesign breakdown of the immune system, and therapeutic ier blood pressure pattern and low cholesterol levels endonuclease target specificity for genome-editing challenges of SLE in both humans and animal mod- leading into a reduced risk of obesity related