THE NATIONAL ACADEMIES PRESS This PDF is available at http://nap.edu/24605 SHARE Preparing for Future Products of Biotechnology DETAILS 230 pages | 7 x 10 | PAPERBACK ISBN 978-0-309-45205-2 | DOI 10.17226/24605 CONTRIBUTORS GET THIS BOOK Committee on Future Biotechnology Products and Opportunities to Enhance Capabilities of the Biotechnology Regulatory System; Board on Life Sciences; Board on Agriculture and Natural Resources; Board on Chemical Sciences and FIND RELATED TITLES Technology; Division on Earth and Life Studies; National Academies of Sciences, Engineering, and Medicine Visit the National Academies Press at NAP.edu and login or register to get: – Access to free PDF downloads of thousands of scientific reports – 10% off the price of print titles – Email or social media notifications of new titles related to your interests – Special offers and discounts Distribution, posting, or copying of this PDF is strictly prohibited without written permission of the National Academies Press. (Request Permission) Unless otherwise indicated, all materials in this PDF are copyrighted by the National Academy of Sciences. Copyright © National Academy of Sciences. All rights reserved. Preparing for Future Products of Biotechnology Preparing for Future Products of Biotechnology Committee on Future Biotechnology Products and Opportunities to Enhance Capabilities of the Biotechnology Regulatory System Board on Life Sciences Board on Agriculture and Natural Resources Board on Chemical Sciences and Technology Division on Earth and Life Studies A Report of Copyright National Academy of Sciences. All rights reserved. Preparing for Future Products of Biotechnology THE NATIONAL ACADEMIES PRESS 500 Fifth Street, NW Washington, DC 20001 This activity was supported by Contract No. EP-C-14-005 with the U.S. Environmental Protection Agency. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project. International Standard Book Number-13: 978-0-309-45205-2 International Standard Book Number-10: 0-309-45205-8 Digital Object Identifier: https://doi.org/10.17226/24605 Library of Congress Control Number: 2017940892 Additional copies of this publication are available for sale from the National Academies Press, 500 Fifth Street NW, Keck 360, Washington, DC 20001; (800) 624-6242 or (202) 334-3313; http://www.nap.edu. Copyright 2017 by the National Academy of Sciences. All rights reserved. Printed in the United States of America Suggested citation: National Academies of Sciences, Engineering, and Medicine. 2017. Preparing for Future Products of Biotechnology. Washington, DC: The National Academies Press. doi: https://doi.org/ 10.17226/24605. Copyright National Academy of Sciences. All rights reserved. Preparing for Future Products of Biotechnology The National Academy of Sciences was established in 1863 by an Act of Con- gress, signed by President Lincoln, as a private, nongovernmental institution to advise the nation on issues related to science and technology. Members are elected by their peers for outstanding contributions to research. Dr. Marcia McNutt is president. The National Academy of Engineering was established in 1964 under the char- ter of the National Academy of Sciences to bring the practices of engineering to advising the nation. Members are elected by their peers for extraordinary contributions to engineering. Dr. C. D. Mote, Jr., is president. The National Academy of Medicine (formerly the Institute of Medicine) was established in 1970 under the charter of the National Academy of Sciences to advise the nation on medical and health issues. Members are elected by their peers for distinguished contributions to medicine and health. Dr. Victor J. Dzau is president. The three Academies work together as the National Academies of Sciences, Engineer ing, and Medicine to provide independent, objective analysis and advice to the nation and conduct other activities to solve complex problems and inform public policy decisions. The National Academies also encourage education and research, recognize outstanding contributions to knowledge, and increase public understanding in matters of science, engineering, and medicine. Learn more about the National Academies of Sciences, Engineering, and Medicine at www.national-academies.org. Copyright National Academy of Sciences. All rights reserved. Preparing for Future Products of Biotechnology Reports document the evidence-based consensus of an authoring committee of experts. Reports typically include findings, conclusions, and recommendations based on information gathered by the committee and committee deliberations. Reports are peer reviewed and are approved by the National Academies of Sciences, Engineering, and Medicine. Proceedings chronicle the presentations and discussions at a workshop, sym- posium, or other convening event. The statements and opinions contained in proceedings are those of the participants and have not been endorsed by other participants, the planning committee, or the National Academies of Sciences, Engineering, and Medicine. For information about other products and activities of the National Academies, please visit nationalacademies.org/whatwedo. Copyright National Academy of Sciences. All rights reserved. Preparing for Future Products of Biotechnology COMMITTEE ON FUTURE BIOTECHNOLOGY PRODUCTS AND OPPORTUNITIES TO ENHANCE CAPABILITIES OF THE BIOTECHNOLOGY REGULATORY SYSTEM Chair RICHARD M. MUrrAY, NAE1, California Institute of Technology, Pasadena Members RICHARD M. AMASINO, NAS2, University of Wisconsin–Madison STEVEN P. BRADBURY, Iowa State University, Ames BArbARA J. EVANS, University of Houston Law Center, Houston, TX STEVEN L. EVANS, Dow AgroSciences, Indianapolis, IN FArrEN ISAACS, Yale University, New Haven, CT RICHARD A. JOHNSON, NAS2, Global Helix LLC, Washington, DC (resigned August 2016) MARTHA A. KREBS, The Pennsylvania State University, Philadelphia JENNIFER KUZMA, North Carolina State University, Raleigh MARY E. MAXON, Lawrence Berkeley National Laboratory, Emeryville, CA RAUL F. MEDINA, Texas A&M University, College Station DAVID REJESKI, Environmental Law Institute, Washington, DC JEffrEY WOLT, Iowa State University, Ames Staff KARA N. LANEY, Study Director (from July 2016) DOUGLAS FRIEDMAN, Study Director (through July 2016) MARILEE K. SHELTON-DAVENPORT, Senior Program Officer ANDREA HODGSON, Postdoctoral Fellow JENNA BRISCOE, Senior Program Assistant AANIKA SENN, Senior Program Assistant FRANCES E. SHArplES, Director, Board on Life Sciences ROBIN A. SCHOEN, Director, Board on Agriculture and Natural Resources TERESA FRYBERGER, Director, Board on Chemical Sciences and Technology 1National Academy of Engineering. 2National Academy of Sciences. v Copyright National Academy of Sciences. All rights reserved. Preparing for Future Products of Biotechnology BOARD ON LIFE SCIENCES Chair JAMES P. COllINS, Arizona State University, Tempe Members ENRIQUETA C. BOND, NAM1, Burroughs Wellcome Fund, Marshall, VA ROGER D. CONE, NAS2, University of Michigan, Ann Arbor NANCY D. CONNEll, Rutgers New Jersey Medical School, Newark JOSEPH R. ECKER, NAS2, Salk Institute for Biological Studies, La Jolla, CA SARAH C. R. ELGIN, Washington University, St. Louis, MO LINDA G. GRIffITH, NAE3, Massachusetts Institute of Technology, Cambridge ELIZABETH HEITMAN, University of Texas Southwestern Medical Center, Dallas RICHARD A. JOHNSON, Global Helix LLC, Washington, DC JUDITH KImblE, NAS2, University of Wisconsin–Madison MARY E. MAXON, Lawrence Berkeley National Laboratory, Emeryville, CA JIll P. MESIROV, University of California, San Diego KAREN E. NELSON, J. Craig Venter Institute, Rockville, MD CLAIRE POMEROY, NAM1, The Albert and Mary Lasker Foundation, New York, NY MARY E. POWER, NAS2, University of California, Berkeley MARGARET RILEY, University of Massachusetts, Amherst LANA SKIrbOll, Sanofi, Washington, DC JANIS C. WEEKS, University of Oregon, Eugene Staff FRANCES E. SHArplES, Director JO L. HUSBANDS, Scholar/Senior Project Director JAY B. LABOV, Senior Scientist/Program Director for Biology Education KATHERINE W. BOwmAN, Senior Program Officer KEEGAN SAWYER, Senior Program Officer AUDREY THEVENON, Program Officer ANDREA HODGSON, Postdoctoral Fellow BETHELHEM M. MEKASHA, Financial Associate JENNA OGILVIE, Research Associate ANGELA KOLESNIKOVA, Senior Program Assistant AANIKA SENN, Senior Program Assistant 1National Academy of Medicine. 2National Academy of Sciences. 3National Academy of Engineering. vi Copyright National Academy of Sciences. All rights reserved. Preparing for Future Products of Biotechnology BOARD ON AGRICULTURE AND NATURAL RESOURCES Chair CHArlES W. RICE, Kansas State University, Manhattan Members PEGGY F. BArlETT, Emory University, Atlanta, GA SUSAN CAPAlbO, Oregon State University, Corvallis GAIL CZARNECKI-MAULDEN, Nestlé Purina PetCare, St. Louis, MO GEBISA EJETA, Purdue University, West Lafayette, IN ROBERT B. GOLDBERG, NAS1, University of California, Los Angeles FRED GOULD, NAS1, North Carolina State University, Raleigh MOllY M. JAHN, University of Wisconsin–Madison RObbIN S. JOHNSON, Cargill Foundation, Wayzata, MN A. G. KAWAMURA, Solutions from the Land, Washington, DC STEPHEN S. KEllEY, North Carolina State University, Raleigh JULIA L. KORNEGAY, North Carolina State University, Raleigh JIM E. RIVIERE, NAM2, Kansas State University, Manhattan Staff ROBIN A. SCHOEN, Director CAMIllA YANDOC AblES, Program Officer JENNA BRISCOE,