ALIX / PDCD6IP Antibody Cat. No.: 18-578 ALIX / PDCD6IP Antibody Immunohistochemistry of paraffin- embedded rat kidney using ALIX / Immunohistochemistry of paraffin-embedded human prostate using ALIX / PDCD6IP antibody (18-578) at PDCD6IP antibody (18-578) at dilution of 1:100 (40x lens). dilution of 1:100 (40x lens). Immunohistochemistry of paraffin- embedded human stomach using ALIX / PDCD6IP antibody (18-578) at dilution of 1:100 (40x lens). Specifications HOST SPECIES: Rabbit September 24, 2021 1 https://www.prosci-inc.com/alix-pdcd6ip-antibody-18-578.html SPECIES REACTIVITY: Human, Mouse, Rat Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of IMMUNOGEN: human ALIX / PDCD6IP (NP_037506.2). TESTED APPLICATIONS: IHC, WB WB: ,1:200 - 1:2000 APPLICATIONS: IHC: ,1:50 - 1:200 POSITIVE CONTROL: 1) HeLa 2) LO2 3) Jurkat 4) Rat brain PREDICTED MOLECULAR Observed: 105kDa WEIGHT: Properties PURIFICATION: Affinity purification CLONALITY: Polyclonal ISOTYPE: IgG CONJUGATE: Unconjugated PHYSICAL STATE: Liquid BUFFER: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. STORAGE CONDITIONS: Store at -20˚C. Avoid freeze / thaw cycles. Additional Info OFFICIAL SYMBOL: PDCD6IP Programmed cell death 6-interacting protein, PDCD6-interacting protein, ALG-2- ALTERNATE NAMES: interacting protein 1, ALG-2-interacting protein X, Hp95, PDCD6IP, AIP1, ALIX, KIAA1375 GENE ID: 10015 USER NOTE: Optimal dilutions for each application to be determined by the researcher. Background and References September 24, 2021 2 https://www.prosci-inc.com/alix-pdcd6ip-antibody-18-578.html This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product BACKGROUND: also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. ANTIBODIES FOR RESEARCH USE ONLY. For additional information, visit ProSci's Terms & Conditions Page. September 24, 2021 3 https://www.prosci-inc.com/alix-pdcd6ip-antibody-18-578.html.