Electronic Supplementary Material (ESI) for Analytical Methods. This journal is © The Royal Society of Chemistry 2019 A practical method for rapid screening and quantitative analysis of 130 pesticide residues in herbal medicines based on Kovats retention index principle: An exemplary study using Panacis quinquefolii radix Peng Tan, Xi-chuan Wei, Hai-zhu Zhang, Ming Niu, Ding-kun Zhang Fig. S1 Typical TIC chromatograms of n-alkanes C9～C33 mixed standard solution Tab. S1 Monitoring ion pairs and collision energy of 130 pesticides Collision Collision Number Pesticide name m/z 1 m/z 2 CAS Number energy (V) energy (V) 1 Dichlorvos 109.0>79.0 8 185.0>93.0 14 62-73-7 2 Dichlobenil 170.9>136.0 14 170.9>100.0 24 1194-65-6 3 Mevinphos-1 127.0>109.0 12 192.0>127.0 12 7786-34-7 3 Mevinphos-2 127.0>109.0 12 192.0>127.0 12 7786-34-7 4 Butylate 156.1>57.0 10 174.1>146.1 6 2008-41-5 5 Molinate 126.1>55.0 14 187.1>126.1 6 2212-67-1 6 Tecnazene 260.9>202.9 14 202.9>142.9 22 117-18-0 7 Omethoate 156.0>110.0 8 110.0>79.0 10 1113-02-6 8 Propachlor 120.0>77.0 20 176.1>57.0 8 1918-16-7 9 Chlorethoxyfos 153.0>97.0 12 153.0>125.0 4 54593-83-8 10 Diphenylamine 169.1>66.0 24 167.1>139.1 28 122-39-4 11 Ethoprophos 200.0>158.0 6 158.0>97.0 18 13194-48-4 12 Chlorpropham 127.1>65.0 22 213.1>171.1 6 101-21-3 13 Trifluralin 306.1>264.1 8 264.1>160.1 18 1582-09-8 14 Dicrotophos 127.1>109.0 12 127.1>95.0 18 141-66-2 15 Monocrotophos 127.1>109.0 12 127.1>95.0 16 6923-22-4 16 Flumethrin 187.0>159.0 10 216.0>187.0 10 69770-45-2 17 Phorate 260.0>75.0 8 231.0>129.0 24 298-02-2 18 Hexachlorobenzene 283.8>248.8 24 283.8>213.8 28 118-74-1 19 Desmedipham 181.0>109.0 10 122.0>94.0 10 13684-56-5 20 Simazine 201.1>173.1 6 201.1>186.1 6 122-34-9 21 Quintozene 264.8>236.8 10 294.8>236.8 16 82-68-8 22 Propazine 125.0>89.0 18 125.0>99.0 18 139-40-2 23 Lindane 180.9>144.9 16 218.9>182.9 8 58-89-9 24 Terbufos 231.0>128.9 26 231.0>174.9 14 13071-79-9 25 Fonofos 137.1>109.1 8 246.0>137.1 6 944-22-9 26 Diazinon 304.1>179.1 10 179.1>137.1 18 333-41-5 27 Phosphamidon-1 127.1>109.1 12 127.1>95.1 18 13171-21-6 27 Phosphamidon-2 127.1>109.1 12 127.1>95.1 18 13171-21-6 28 Pyrimethanil 198.1>183.1 14 198.1>118.1 28 53112-28-0 29 Chlorothalonil 263.9>168.0 24 263.9>228.8 18 1897-45-6 30 Tefluthrin 177.0>127.1 16 177.0>137.1 16 79538-32-2 31 Propanil 217.0>161.0 10 160.9>99.0 24 709-98-8 32 Chlorpyriphos-methyl 285.9>93.0 22 287.9>93.0 22 5598-13-0 33 Metribuzin 198.1>82.0 14 198.1>110.1 10 21087-64-9 34 Vinclozolin 212.0>172.0 16 285.0>212.0 12 50471-44-8 35 Parathion-methyl 263.0>109.0 14 125.0>47.0 12 298-00-0 36 Tolclofos-methyl 264.9>249.9 14 264.9>93.0 24 57018-04-9 37 Alachlor 188.1>160.1 10 188.1>132.1 18 15972-60-8 38 Heptachlor 271.8>236.9 20 273.8>238.9 16 76-44-8 39 Propisochlor 162.1>120.1 14 162.1>147.1 14 86763-47-5 40 Ametryn 227.1>185.1 6 227.1>58.0 14 834-12-8 41 Metalaxyl 249.2>190.1 8 206.1>132.1 20 57837-19-1 42 Prometryn 226.1>184.1 10 241.2>184.1 12 7287-19-6 43 Pirimiphos-methyl 290.1>125.0 22 290.1>233.1 12 29232-93-7 44 Fenitrothion 277.0>260.0 6 277.0>109.1 14 122-14-5 45 Bromacil 206.9>189.9 16 204.9>187.9 14 314-40-9 46 Malathion 173.1>99.0 14 173.1>127.0 6 121-75-5 47 Chlorpyrifos 196.9>168.9 14 313.9>257.9 14 2921-88-2 48 Aldrin 262.9>191.0 34 262.9>193.0 28 309-00-2 Fenthion-d6 284.0>115.0 20 284.0>169.0 15 1189662-83-6 49 Fenthion 278.0>109.0 20 278.0>169.0 14 55-38-9 50 Chlorthal-dimethyl 298.9>220.9 24 300.9>222.9 26 1861-32-1 51 Triadimefon 208.1>181.0 10 208.1>111.0 22 43121-43-3 52 Dicofol 139.0>111.0 16 139.0>75.0 28 0-00-0 53 Phthalide 272.0>242.9 14 243.0>214.9 9 27355-22-2 54 Isofenphos-methyl 199.0>121.0 14 241.1>121.1 22 99675-03-3 55 Pendimethalin 252.1>162.1 10 252.1>191.1 8 40487-42-1 56 Fipronil 366.9>212.9 30 368.9>214.9 30 120068-37-3 57 Penconazole 248.1>157.1 26 159.1>123.1 22 66246-88-6 58 Tolyfluanid 238.0>137.1 14 181.1>138.1 10 731-27-1 59 Phenthoate 273.9>125.0 20 273.9>246.0 6 2597-03-7 60 Quinalphos 146.1>118.0 10 146.1>91.0 24 13593-03-8 61 Captan 149.1>79.1 14 149.1>105.1 4 133-06-2 62 Procymidone 283.0>96.0 10 285.0>96.0 10 32809-16-8 63 Triadimenol-1 168.1>70.0 10 128.1>65.0 22 55219-65-3 63 Triadimenol-2 168.1>70.0 10 128.1>65.0 22 55219-65-3 64 Folpet 259.9>130.0 14 261.9>130.0 18 133-07-3 65 Methoprene 111.1>55.0 18 111.1>83.0 12 40596-69-8 66 Methidathion 145.0>85.0 8 145.0>58.0 14 950-37-8 67 Trans-Chlordane 374.8>265.9 26 372.8>263.9 28 5103-74-2 68 Paclobutrazol 236.1>125.0 14 236.1>167.0 10 76738-62-0 69 Butachlor 176.1>147.1 14 188.1>160.1 12 23184-66-9 70 Alpha-Endosulfan 194.9>160.0 8 194.9>125.0 24 959-98-8 71 Flutriafol 219.1>123.1 14 219.1>95.0 28 76674-21-0 72 Fenamiphos 303.1>195.1 8 288.1>260.1 6 22224-92-6 73 Napropamide 128.1>72.0 6 100.0>72.0 8 15299-99-7 74 Prothiophos 266.9>238.9 10 309.0>238.9 14 34643-46-4 75 Isoprothiolane 231.1>189.0 10 290.1>118.0 14 50512-35-1 76 Pretilachlor 262.1>202.1 10 238.1>162.1 10 51218-49-6 77 Profenofos 338.9>268.9 18 336.9>266.9 14 41198-08-7 78 Oxadiazon 258.0>175.0 8 302.0>175.0 14 19666-30-9 79 Tribufos 202.0>147.0 6 202.0>113.0 20 78-48-8 80 Myclobutanil 179.1>125.0 14 179.1>152.0 8 88671-89-0 81 Flusilazole 233.1>165.1 14 206.1>151.1 16 85509-19-9 82 Oxyfluorfen 252.0>196.0 22 361.0>300.0 14 42874-03-3 83 Chlorfenapyr 247.1>227.0 16 139.0>102.0 12 122453-73-0 84 Fluazifop-P-butyl 383.0>282.0 15 282.0>91.0 20 79241-46-6 85 Endrin 262.9>191.0 30 262.9>193.0 28 72-20-8 86 Flufenpyr-ethyl 408.0>345.0 16 408.0>321.0 14 188489-07-8 87 Beta-Endosulfan 194.9>160.0 8 194.9>125.0 24 33213-65-9 88 Diniconazole 268.0>232.0 12 270.0>234.0 10 83657-24-3 89 Ethion 153.0>97.0 14 230.9>129.0 24 563-12-2 90 Mepronil 119.1>91.0 12 119.1>65.0 24 55814-41-0 91 Triazophos 161.0>134.0 8 161.0>106.0 14 24017-47-8 92 Benalaxyl 148.1>105.1 16 148.1>79.1 24 71626-11-4 93 Trifloxystrobin 222.1>190.1 4 222.1>130.1 12 141517-21-7 94 Edifenphos 173.0>109.0 10 310.0>173.0 14 17109-49-8 95 Norflurazon 145.0>95.0 18 303.0>145.0 22 27314-13-2 96 Propiconazole-1 173.0>145.0 16 173.0>109.0 28 60207-90-1 96 Propiconazole-2 173.0>145.0 16 173.0>109.0 28 60207-90-1 97 Quinoxyfen 237.1>208.1 28 307.1>237.1 22 124495-18-7 98 4,4’-DDT 235.0>165.0 24 237.0>165.0 28 50-29-3 99 Tebuconazole 250.1>125.1 22 125.1>89.0 18 107534-96-3 100 Diclofop-ethyl 340.0>253.0 14 253.0>162.0 22 51338-27-3 101 Piperonyl-butoxide 176.1>131.1 12 176.1>117.1 20 51-03-6 102 Zoxamide 187.0>159.0 16 187.0>123.0 24 156052-68-5 103 Iprodione 314.0>245.0 12 314.0>56.0 22 36734-19-7 104 Acetamiprid 152.0>116.0 18 152.0>89.0 26 135410-20-7 105 Phosmet 160.0>77.0 24 160.0>133.0 14 732-11-6 106 Bifenthrin 181.1>166.1 12 181.1>179.1 12 82657-04-3 107 Bromopropylate 340.9>182.9 18 340.9>184.9 20 18181-80-1 108 Etoxazole 359.1>187.1 14 330.1>300.1 26 153233-91-1 109 Fenpropathrin 181.1>152.1 22 265.1>210.1 12 39515-41-8 110 Phosalone 182.0>111.0 14 182.0>138.0 8 2310-17-0 111 Ipconazole 125.0>89.1 18 125.0>99.0 18 125225-28-7 112 Metrafenone 393.0>363.0 20 379.0>364.0 10 220899-03-6 113 Fenoxaprop-ethyl 361.1>288.1 12 288.1>119.1 12 66441-23-4 114 Oryzalin 275.0>258.0 6 317.0>258.0 14 19044-88-3 115 Permethrin-1 183.1>153.1 14 183.1>168.1 14 52645-53-1 115 Permethrin-2 183.1>153.1 14 183.1>168.1 14 52645-53-1 116 Coumaphos 362.0>109.0 16 362.0>226.0 14 56-72-4 117 Pyridaben 147.1>117.1 22 147.1>132.1 14 96489-71-3 118 Fenbuconazole 198.1>129.1 10 129.1>102.1 18 114369-43-6 119 Cyfluthrin-1 163.1>127.1 6 163.1>91.0 14 68359-37-5 119 Cyfluthrin-2 163.1>127.1 6 163.1>91.0 14 68359-37-5 119 Cyfluthrin-3 163.1>127.1 6 163.1>91.0 14 68359-37-5 119 Cyfluthrin-4 163.1>127.1 6 163.1>91.0 14 68359-37-5 120 Cypermethrin-1 163.1>127.1 6 163.1>91.0 14 52315-07-8 120 Cypermethrin-2 163.1>127.1 6 163.1>91.0 14 52315-07-8 120 Cypermethrin-3 163.1>127.1 6 163.1>91.0 14 52315-07-8 120 Cypermethrin-4 163.1>127.1 6 163.1>91.0 14 52315-07-8 121 Flucythrinate-1 199.1>157.1 10 157.1>107.1 12 70124-77-5 121 Flucythrinate-2 199.1>157.1 10 157.1>107.1 12 70124-77-5 122 Pyridalyl 204.1>148.1 20 204.1>176.1 12 179101-81-6 123 Flumioxazin 287.1>259.1 12 354.1>326.1 8 103361-09-7 124 Fenvalerate-1 225.1>119.1 20 225.1>147.1 10 51630-58-1 124 Fenvalerate-2 225.1>119.1 20 225.1>147.1 10 51630-58-1 125 Fluvalinate-1 250.1>55.0 20 250.1>200.0 20 69409-94-5 125 Fluvalinate-2 250.1>55.0 20 250.1>200.0 20 69409-94-5 126 Difenoconazole-1 323.0>265.0 14 265.0>202.0 20 119446-68-3 126 Difenoconazole-2 323.0>265.0 14 265.0>202.0 20 119446-68-3 127 Deltamethrin-1 180.9>151.9 22 252.9>93.0 20 52918-63-5 127 Deltamethrin-2 180.9>151.9 22 252.9>93.0 20 52918-63-5 128 Azoxystrobin 344.1>329.1 16 388.1>345.1 18 131860-33-8 129 Famoxadone 224.1>196.1 10 330.1>224.1 10 131807-57-3 130 Fluthiacet-methyl 403.0>56.0 24 403.0>84.0 14 117337-16-6 Notes: (1) Compound Fenthion-d6 is internal standard compound.