Anti-DFFA Polyclonal Antibody Cat: K001939P Summary: 【Product name】: Anti-DFFA antibody 【Source】: Rabbit 【Isotype】: IgG 【Species reactivity】: Human Mouse Rat 【Swiss Prot】: O00273 【Gene ID】: 1676 【Calculated】: MW: 29/36kDa 【Observed】: MW: 36kDa 【Purification】: Affinity purification 【Tested applications】: WB IHC IF 【Recommended dilution】: WB 1:500-2000. IHC 1:50-200. IF 1:50-100. 【WB Positive sample】: HepG2 【IHC Positive sample】: Human breast cancer 【Subcellular location】: Cytoplasm. 【Immunogen】: Recombinant protein of human DFFA. 【Storage】: Shipped at 4°C. Upon delivery aliquot and store at -20°C Background: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Sales:[email protected] For research purposes only. Tech:[email protected] Please visit www.solarbio.com for a more product information Verified picture Western blot analysis with DFFA antibody Immunohistochemistry of paraffin-embedded diluted at 1:1000 Human breast cancer with DFFA antibody diluted at 1:100 Sales:[email protected] For research purposes only. Tech:[email protected] Please visit www.solarbio.com for a more product information.