[Supplemental Table 1] Upregulated genes in colorectal cancer compared with paired normal mucosa Genes Description Probe p value Fold IL8 interleukin 8 202859_x_at 2.2E-06 85.8 MMP1 matrix metallopeptidase 1 204475_at 4.5E-06 48.1 MMP3 matrix metallopeptidase 3 205828_at 0.000269 46.1 FOXQ1 forkhead box Q1 227475_at 1E-07 27.6 CTHRC1 collagen triple helix repeat containing 1 225681_at p < 1e-07 26.2 CXCL6 chemokine (C-X-C motif) ligand 6 206336_at 6.23E-05 24.8 MMP10 matrix metallopeptidase 10 (stromelysin 2) 205680_at 0.000808 24.8 SRPX2 sushi-repeat-containing protein, X-linked 2 205499_at 4E-07 22.8 CDNA FLJ14388 fis, clone HEMBA1002716 229802_at 4.5E-06 22.6 MRNA full length insert cDNA clone EUROIMAGE 1913076 226237_at 4.93E-05 20.9 KIAA1199 KIAA1199 212942_s_at 0.000824 20.7 CLDN1 Claudin 1 222549_at 1E-07 20.6 CXCL1 chemokine (C-X-C motif) ligand 1 204470_at 1E-07 19.9 LY6G6D lymphocyte antigen 6 complex, locus G6D 207457_s_at 5.38E-05 17.9 hCG_1815491 hCG1815491 238021_s_at 1.17E-05 13.8 COL12A1 collagen, type XII, alpha 1 225664_at 3E-07 12.9 SULF1 sulfatase 1 212353_at 3E-07 12.6 CXCL2 chemokine (C-X-C motif) ligand 2 209774_x_at 4.13E-05 12.5 WNT5A wingless-type MMTV integration site family, member 5A 213425_at p < 1e-07 11.7 WNT5A wingless-type MMTV integration site family, member 5A 205990_s_at p < 1e-07 11.5 HS6ST2 heparan sulfate 6-O-sulfotransferase 2 230030_at 4.09E-05 11.2 UBD ubiquitin D 205890_s_at 5.69E-05 11 Transcribed locus 238967_at 9.11E-05 10.8 JUB jub, ajuba homolog (Xenopus laevis) 225806_at p < 1e-07 10.6 ANLN anillin, actin binding protein 222608_s_at 3E-07 10.5 SULF1 sulfatase 1 212344_at 4.9E-06 10.5 SLC6A6 solute carrier family 6, member 6 228754_at p < 1e-07 10.4 PHLDA1 pleckstrin homology-like domain, family A, member 1 225842_at 1E-07 10.4 WNT2 wingless-type MMTV integration site family member 2 205648_at 1.4E-06 10.2 PSAT1 phosphoserine aminotransferase 1 223062_s_at 3E-07 10 Fold: fold change between colorectal cancer and paired normal colonic mucosa. [Supplemental Table 2] Microarray analysis for DLD-1 cells transfected with FOXQ1-targeting siRNA or control-siRNA. Gene symbol Description Probe set Fold change SGPP2 sphingosine-1-phosphate phosphotase 2 244780_at 0.25 RER1 retention in endoplasmic reticulum 1 RER1 213114_at 0.26 homolog TRIM65 tripartite motif-containing 65 235081_x_at 0.27 LRRC37A3 Leucine rich repeat containing 37, member A3 244478_at 0.28 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 202284_s_at 0.29 HNRPM Heterogeneous nuclear ribonucleoprotein M 243593_s_at 0.32 C14orf135 Chromosome 14 open reading frame 135 1563259_at 0.32 RCE1 RCE1 homolog, prenyl protein peptidase 205333_s_at 0.33 FOXQ1 forkhead box Q1 227475_at 0.33 SFPQ Splicing factor proline/glutamine-rich 226898_s_at 0.35 PDE6D Phosphodiesterase 6D, cGMP-specific, rod, delta 231065_at 0.35 PSMD5 Proteasome 26S subunit, non-ATPase, 5 1561640_at 0.36 TYW1 TRNA-yW synthesizing protein 1 homolog 240800_x_at 0.37 ZNF473 zinc finger protein 473 213130_at 0.37 ZNF41 zinc finger protein 41 1553216_at 0.38 Transcribed locus 232493_at 0.38 PLK4 polo-like kinase 4 211088_s_at 0.39 CPOX Coproporphyrinogen oxidase 234059_at 0.39 CCDC50 coiled-coil domain containing 50 235051_at 0.40 .