DOCTORAL FELLOWSHIPS FOR CLINICIANS 2018 Applications are invited for Crick–Cancer Research UK and Crick doctoral fellowships for clinicians at the Francis Crick Institute (the Crick). These fellowships provide an opportunity for outstanding clinicians to perform innovative biomedical discovery research for three years while following the Crick’s clinical PhD programme. The Crick carries out multidisciplinary research Fellows will be based at the Crick, supported by teams dedicated to unravelling the scientific mechanisms of comprising a Crick research group leader, at least one living organisms, helping us to understand why disease supervisor from one of Crick’s five clinical PhD programme develops and find new ways to prevent, diagnose and partners (Barts Cancer Institute/Queen Mary University treat illnesses. One of the Crick’s aims is to provide an of London, Imperial College London, The Institute of environment to advance the understanding of cancer at Cancer Research, King’s College London and UCL) and at the most fundamental level and to speed application of least one clinician. this knowledge for therapeutic and diagnostic patient benefit. Crick-Cancer Research UK projects • Cancer outcome in standard and immune checkpoint blockade therapies. Dinis Calado (Crick), Jude Fitzgibbon (Barts Cancer Institute/QMUL) and Peter Johnson (University of Southampton) • Investigation of the mechanisms by which RAS mutant lung cancer evades the immune system. Julian Downward (Crick), Alan Melcher (ICR) and Sanjay Popat (ICR, Royal Marsden) • Genomic assessment of DNA damage in skin cancers. Nicholas Luscombe (Crick), Fiona Watt and Magnus Lynch (King’s College London) • Identification of novel targets to inhibit autophagy in advanced pancreatic cancer. Sharon Tooze (Crick), Christopher Heeschen (Barts Cancer Institute, QMUL) and David Propper (Barts and The London NHS Trust) • The serum response factor (SRF) network in cancer development. Richard Treisman (Crick) and Daniel Hochhauser (UCL) • Metabolic stratification of tumours for chemotherapy. Mariia Yuneva (Crick), Robert Stein and Gyorgy Szabadkai (UCL) Crick projects • Mechanisms and therapeutic exploitation of alternative lengthening of telomeres (ALT) acquisition in cancers. Simon Boulton (Crick) and Daniel Hochhauser (UCL) • Regulation of IL-10 versus pro-inflammatory cytokines in human macrophages and dendritic cells. Anne O’Garra (Crick) and Catherine Hawrylowicz (King’s College London) • Environmental influences on intestinal homeostasis and inflammation. Brigitta Stockinger (Crick) and Graham Lord (King’s College London) • The role of actin-related protein (Arp) 2/3 complex isoforms in muscle development, homeostasis and early-onset neuromuscular disorders. Michael Way (Crick) and Heinz Jungbluth (King’s College London) We are looking for talented and motivated clinicians from all medical and surgical specialities who are passionate about research, have a strong academic track record and hold full GMC registration or equivalent. These are full-time research positions with limited participation in clinical activities. They are fully funded for three years, and PhD registration will be with the appropriate programme partner institution. Successful candidates will receive a salary commensurate with their current experience, paid on the clinical academic scale. For information on positions, eligibility and how to apply, visit: http://crick.ac.uk/about-us/jobs-and-study/clinical-fellows Application deadline: Tuesday 14 November 2017 Interviews: Tuesday 6 February 2018 Start date: September 2018 .