95 Journal of Bioscience and Applied Research, Sep.2017, Vol.3, No.3, PP.95-130 pISSN: 2356-9174, eISSN: 2356-9182 JBAAR Journal of Bioscience and Applied Research WWW.JBAAR.ORG Gene-Behavior Theory: Relation between behavioral deviation and satellite DNA causing increased selective disease susceptibility within communities Seif Salah-Eldin Mohammed Department of Immunology and Allergy, Medical Research Institute, Alex, Egypt. [email protected] +201111017413/ +201202025770 Abstract: The regional differences in the mix of cancers and diseases provoke many questions regarding the causes that control the susceptibility, in this work, it is proven that the behavioral deviance is the main cause for the increased selective disease susceptibility through cross-sectional studies. Theoretically, it is suggested that human leucocyte antigens is a marker for a deviated ancestors, and satellite DNA is an expression to the common-sense and reflects the behavior (The Gene-Behavior Theory), causing increased disease susceptibility if deviated. The conformity approach which used in the human-community theory explain many social and genetic mechanisms, especially, how human-human interactions affect the genetic damage/repair. Keywords: Disease susceptibility. Behavioral deviation. Common sense. HLA. Satellite DNA. Genetic repair. The Gene-Behavior Theory. Introduction: Cancer constitutes an enormous burden on society in more and less developed countries, and has more and less economically developed countries surpassed breast cancer as the leading cause of alike. The occurrence of cancer is increasing cancer death among females in more developed because of the growth and aging of the population, countries; breast cancer remains the leading cause of as well as an increasing prevalence of established cancer death among females .Other leading causes risk factors such as smoking, overweight, physical of cancer death in more developed countries include inactivity, and changing reproductive patterns colorectal cancer among males and females and associated with urbanization and economic prostate cancer among males. In less developed development. (1)But occurrence of this risk factors countries, liver and stomach cancer among males don’t emphasize that the Person will be affected by a and cervical cancer among females are also leading disease (cancer as example). And detecting the causes of cancer death. This disparity reflects major leading cause for the continuous increasing of regional differences in the mix of cancers. (1) diseases incidence still a big challenge. The regional differences in the mix of cancer Based on GLOBOCAN estimates, about 14.1 provoke the question of: why a specific disease has million new cancer cases and 8.2 million deaths high prevalence in a community while shows low occurred in 2012 worldwide. Over the years, the incidence in the neighboring countries, although burden has shifted to less developed countries, they share similar environment? The question is which currently account for about 57% of cases and about what is the factors that draw the susceptibility 65% of cancer deaths worldwide. Lung cancer is the of a community. leading cause of cancer death among males in both 96 Journal of Bioscience and Applied Research, Sep.2017, Vol.3, No.3, PP.95-130 pISSN: 2356-9174, eISSN: 2356-9182 If the “increased susceptibility” problem will be -The first question: Is their similarity between cells handled, it is important to be handled in the light of in body and humans in community? the genetic regions that linked to the inherited -The second question: If yes, to what extent diseases as an indicator of increased susceptibility. humanity freedom, is it has a range like the cell- cell The first suspected region is the human leucocyte interaction or it absolute? antigen region (HLA), which is the human major -The third question: If it has a range, is the histocompatibility molecule that plays a pivotal role significant deviation in human-human interaction in paternity issues and organ transplantation, (2) in lead to disease outbreak in community like what addition HLA is considered accused of association happens in deviated or altered cells in body? And to with diseases, and the mechanisms of association what extent the deviated behavior can be translated has been suggested, By contrast, the basic to DNA mutations? mechanism by which a particular HLA became a -The fourth question: If the deviated behavior cause marker of disease is still unknown. However, the DNA change, which type or region of DNA that disease may occur in individuals which haven’t the may reflect this deviation? corresponding guilt HLA type,(3) this is controversial, -The fifth question: Is there any evidence that any this data lead to another question of: why the certain type of failed human-human interaction (Behavioral HLA type may indicate increased susceptibility to a deviation) lead to corresponding disease? disease, while this disease may occur in presence of another HLA type? If there, so relation between human-human interaction and community health can be assumed as Surprisingly, researches revealed that the Non- a causation. These questions will be answered coding DNA play a role in disease susceptibility consecutively in this article. especially satellite DNA (tandemly repeated DNA), satellite DNA has more recently been reconsidered Human-Community Theory: Novel as having various functions. Moreover, due to the epidemiological perspective repetitive nature of the composing elements, their presence in the genome is associated with high frequency mutations, epigenetic changes and According to any perspective can epidemiologist modifications in gene expression patterns, with a solve Health problems in widely, effective, specific potential to lead to human disease. Therefore, the and low cost strategies? At first, epidemiology is satellite DNA study will be beneficial for developing often described as the basic science of public health, a treatment of satellite related diseases, and in and for good reason. First, epidemiology is a studying the “increased susceptibility” problem, quantitative discipline that relies on a working especially when be known that the exact molecular knowledge of probability, statistics, and sound mechanisms of how satellite DNA can be involved research methods. Second, epidemiology is a in pathology remain largely unexplored, particularly method of causal reasoning based on developing and when satellite DNA is not located in the coding testing hypotheses grounded in such scientific fields region of the affected gene.(4)I will try to explain the as biology, behavioral sciences, physics, and causes of disease outbreak in the light of this two ergonomics to explain health-related behaviors, genetic regions. states, and events. However, epidemiology is not just a research activity but an integral component of As an attempt to resolve these questions, the public health, providing the foundation for directing author initiate the Community-Human theory, in this practical and appropriate public health action based theory it hypothesized that the individuals in on this science and causal reasoning. (5) community is like cells in body, in order to establish some incontrovertibly facts firstly for the medical Epidemiology was originally focused exclusively community and second for the all communities, as on epidemics of communicable diseases, but was we all share the same medical rules in our body, subsequently expanded to address endemic therefore it will act as a standard perspective. communicable diseases and non-communicable diseases. Basic epidemiologic methods tend to rely Comparing the cell-cell interaction in body to on careful observation and use of valid comparison human-human interaction in community led to groups to assess whether what was observed, also important suggested questions: draws on methods from other scientific fields, 97 Journal of Bioscience and Applied Research, Sep.2017, Vol.3, No.3, PP.95-130 pISSN: 2356-9174, eISSN: 2356-9182 including biostatistics and informatics, with biologic, with each other as normal cells. Later it will be economic, social, and behavioral sciences. (5) plausible to believe that the optimal and the most Although epidemiologists and direct health-care advanced nation ‘community' system that aim to providers (clinicians) are both concerned with healthy environment is close to the healthy body occurrence and control of disease, they differ greatly system in his harmonic interacted cells which are in how they view “the patient.” The clinician is very advanced, committed and specialized. However, concerned about the health of an individual; the the body still more advanced than any community! epidemiologist is concerned about the collective health of the people in a community or population. Similarities in molecular level (Molecules of In other words, the clinician’s “patient” is the affiliation): Some evidence demonstrates that the individual; the epidemiologist’s “patient” is the developed community is like healthy body, in community. (5) molecular level, this similarity exists in the level of the DNA, which in the body is similar to the Novel perspective (qualitative view) information of a human within a community. In this topic the community will be studied as a one patient "epidemiologist view" but in new fashion, As each one of us has information that is shared the view of epidemiologist to the community as one with others around (ex/Language), this type of basic patient is a