Virginia Drug Discovery Consortium VirginiaBrainRx: A Symposium on Drug Discovery for the Brain May 23 - 24, 2016 Omni Richmond Hotel Richmond, Virginia Welcome letter May 23, 2016 Dear Symposium Participants: On behalf of the Organizing Committee, it is my great pleasure to welcome you to Richmond and to the VirginiaBrainRx Symposium. This Symposium includes five keynote lectures and several invited lectures from distinguished scientists, and also features poster presentations by scientists from around the Commonwealth. One of the major purposes of this Symposium is to provide networking opportunities that could foster new inter-university and public-private collaborative projects in brain drug-discovery. The NIH Roadmap for Research states “The scale and complexity of today’s … research problems increasingly demand that scientists move beyond the confines of their own discipline and explore new organizational models for team science….…”, and this Symposium has the goal of furthering such collaborations, especially when it comes to the discovery, development, and delivery of drugs to treat brain illness. The organizers hope that everyone will take advantage of the poster sessions and social times to meet new colleagues and to explore new collaborations. This Symposium is the first major public project of the fledgling irginia“V Drug Discovery Consortium.” This Consortium has the aim of fostering collaborative drug discovery research in all disease areas between Virginia’s universities and the pharmaceutical and biotech industries, and it plans to sponsor regular Symposia on different aspects of drug discovery, with the next one tentatively scheduled for Spring 2017. A short questionnaire is included in your registration materials, and I hope that you will take the time to complete this on Tuesday so as to guide the organizers in planning future Symposia. The organizers wish to thank all the sponsoring institutions (The University of Virginia, Virginia Commonwealth University, Virginia Tech, George Mason University, Virginia Biosciences Health Research Corporation, Eastern Virginia Medical School and Old Dominion University) for their support, which allowed for the moderate cost of the Symposium. Full details of these sponsors are included in the following pages. The organizers hope that you enjoy both the scientific program and the collaborative opportunities of the VirginiaBrainRx Symposium, and we look forward to seeing many of you at the next Symposium. Sincerely yours David G. I. Kingston Symposium Chair List of Organizing Committee Members and Sponsoring Organizations VirginiaBrainRx Organizing Committee Sean Bates (Venue & Logistics, Virginia Commonwealth University) Paul R. Carlier (Program, Virginia Tech) Richard A. Glennon (Venue & Logistics, Virginia Commonwealth University) Mike Grisham (VBHRC, “The Catalyst”) B. Frank Gupton (Virginia Commonwealth University) David G. I. Kingston (Symposium Chair, Virginia Tech) John S. Lazo (Marketing & Promotion, University of Virginia) Robert J. Meyer (University of Virginia) Elizabeth Sharlow (University of Virginia) Frank D. Yocca (Bioxcel) Sponsors Gold Sponsors The University of Virginia (including the Virginia Center for Translational and Regulatory Sciences, the Office of the Vice-President for Research, the Department of Pharmacology, and the Fiske Drug Discovery Laboratory) Virginia Commonwealth University (School of Engineering, School of Pharmacy, and the Department of Medicinal Chemistry) Virginia Tech (College of Science and the Fralin Life Science Institute) Silver Sponsors George Mason University Virginia Biosciences Health Research Corporation Bronze Sponsors Eastern Virginia Medical School Old Dominion University VirginiaBrainRx: A Symposium on Drug Discovery for the Brain May 23-24, 2016 Omni Hotel Richmond, VA Day 1 (Monday May 23, 2016) Chairs: David G. I. Kingston, Richard A. Glennon 11:00 am Registration opens 1:00 pm Symposium Opens: Welcome from David G. I. Kingston, Ph.D. (Virginia Tech), Meeting Chair Welcome from VBHRC/The Catalyst: Mike Grisham (Virginia Biosciences Health Research Corporation) Welcome from Delegate John O’Bannon, M.D. (73rd District, Virginia) 1:15 pm “Origins, Status, and Future of the Virginia’s Neuroscience Initiative” Mike Friedlander, Ph.D. (Virginia Tech Carilion Research Institute) George Bloom, Ph.D. (Biology and Cell Biology, University of Virginia) David Cifu, M. D. (Neurotrauma Consortium, Virginia Commonwealth University) 1:30 pm Keynote 1 “Developing Therapeutics for Substance Use Disorders: Progress and Outlook” Phil Skolnick, Ph.D., D.Sc. (hon.) (Director, DTMC, NIDA, NIH) 2:10 pm Q & A 2:15 pm Keynote 2 “Opportunities in CNS Drug Development: an Industry Perspective” Darryle Schoepp, Ph. D. (V.P. and Therapeutic Area Head, Neuroscience, Merck) 2:55 pm Q & A 3:00 pm Coffee break/Poster Session 4:00 pm Keynote 3 “Lessons Learned in Building an Academic Drug Discovery Center” Carrie K. Jones, Ph. D. (Director, In vivo and Translational Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery) 4:40 pm Q & A 4:45 pm Opportunities for inter-institutional collaboration within the Commonwealth: Panel Discussion with Representatives from EVMS, ODU, GMU, UVA, VCU, VT. (Mike Grisham, VBHRC, Moderator) 5:25 pm Day 1 Wrap-up: Richard Glennon, Ph.D. (Virginia Commonwealth Univ.) 5:30 pm Social Hour & Networking 6:15 pm Welcoming remarks by the Honorable Ralph S. Northam, M.D., Lieutenant Governor of the Commonwealth of Virginia. Dinner Day 2 (Tuesday, May 24, 2016) Chairs: John S. Lazo, Paul R. Carlier 7:30 am Breakfast 8:30 am Welcome to Day 2: John S. Lazo, Ph.D. (Univ. of Virginia) 8:35 am Keynote 4 “Parkinson’s Disease: Meeting the Challenge” Todd Sherer, Ph. D. (CEO, Michael J. Fox Foundation) 9:15 am Q & A 9:20 am Introduction to the Invited Speaker Session. 9:25 am “Amyloid & Tau: The Trigger and Bullet in Alzheimer’s Disease Pathogenesis” George Bloom, Ph. D. (Professor of Biology & Cell Biology, University of Virginia) 9:40 am “The Medicines for All Initiative” B. Frank Gupton, Ph.D. (Chair, Chemical & Life Science Engineering, Virginia Commonwealth University) 9:55 am “New use for an old drug: Sulfasalazine to treat tumor associated epilepsy” Harald Sontheimer, Ph. D. (Director, Neuroscience Program, Virginia Tech) 10:10 am Coffee Break/Poster Session 11:10 am “Insights from an Integrated Approach to Animal Behavioral Models” Larry D. Sanford, Ph.D. (Professor of Pathology and Anatomy, Eastern Virginia Medical School) 11:25 am “Pre-clinical and Clinical Applications of Drug and Gene Electrotransfer” Richard Heller, Ph.D. (Professor, Frank Reidy Center for Bioelectrics, Old Dominion University) 11:40 am “The role of the nicotinic acetylcholine receptor in axon growth and regeneration” Nadine Kabbani, Ph.D. (Associate Professor, Molecular Neuroscience and Krasnow Institute for Advanced Study, George Mason University) 11:55 am “The NIH Blueprint Neurotherapeutics Network” Amir Tamiz, Ph. D. (Program Officer, NINDS, Office of Translational Research, NIH) 12:10 am Closing Remarks for the Morning Session 12:15 pm Lunch and Networking 1:15 pm Keynote 5 “Challenges and Opportunities in Psychiatric Drug Development” Thomas Laughren, M.D. (Director, Regulatory Affairs, MGH Clinical Trials Network and Institute) 1:55 pm Q & A 2:00 pm Panel Discussion: What are Industry’s “Conditions for Satisfaction” in Drug Discovery Collaborations with Academia? Mike Grisham (VBHRC), Moderator Christopher L. Shaffer, Ph.D. (Pfizer), Ryan Westphal, Ph.D. (Lilly), Michael Wood, Ph.D. (AstraZeneca), Frank D. Yocca, Ph.D. (BioXcel). 2:50 pm Closing Remarks: Paul R. Carlier, Ph.D. (Virginia Tech). Speaker Biographies Members of Government of the Commonwealth of Virginia The Honorable Ralph S. Northam, M.D., Lieutenant Governor of the Commonwealth of Virginia Ralph Northam grew up on the Eastern Shore, working on the Chesapeake Bay, before attending Virginia Military Institute where he graduated with distinction and was President of the Honor Court. After graduating from Eastern Virginia Medical School, Ralph served eight years active duty in the United States Army, rising to the rank of Major. Upon his return from treating soldiers injured in Desert Storm, Ralph began practicing pediatric neurology at Children’s Hospital of the King’s Daughters in Norfolk. Ralph also serves as Assistant Professor of Neurology at Eastern Virginia Medical School and has seventeen years of volunteer service as Medical Director for the Edmarc Hospice for Children in Portsmouth. As a State Senator from 2008-2013, Ralph scored numerous major legislative accomplishments, including the prohibition on smoking in restaurants, protecting young athletes who have sustained concussions, improving the health of the Chesapeake Bay, and shielding our first responders from communicable diseases. Elected Lieutenant Governor on November 5, 2013, Ralph’s top priorities are economic development, strengthening early childhood education, implementing meaningful mental health reform, protecting women’s health care access, and carefully stewarding the Commonwealth’s environmental resources. As Virginia’s Lieutenant Governor, Ralph Northam presides over the State Senate. Delegate John M. O’Bannon III, M.D., 73rd District of the Commonwealth of Virginia Dr. John O’Bannon is a graduate of Hargrave Military Academy and the University of Richmond. John attended medical school at the Medical College of Virginia (MCV), where he was elected President of the Student Body. As a resident at