AHNS 2015 Translational Research Meeting on Transforming Patient Care Through Innovative Research April 21-22, 2015 Sheraton Boston Hotel, 39 Dalton Street, Boston, MA 02199 FINAL PROGRAM www.ahns.info THE RESEARCH AND EDUCATION FOUNDATION OF THE AMERICAN HEAD AND NECK SOCIETY Dear Colleagues, As we all know, head and neck cancer is not one of the more “publicized” cancers and often overlooked by both the general public and research funding sources. However, we believe that this is slowly starting to change. With increased attention on head and neck cancer, the Research and Education Foundation believes this is an opportunity to strengthen and expand our impact. With your commitment to the Foundation, we can reverse the trend of declining funding for head and neck cancer research! Presently the Research and Education Foundation supports two research awards each year. We are proud to fund these grants but there are more to cover. We would like to create more opportunities for young clinicians and researchers to explore unique and innovative treatments which may one day lead to a cure. To do as much, the Foundation needs to increase its asset base. There are three targeted ways for you to support the Foundation which are designed to provide immediate revenue as well as to increase the capital base for the long term with the goal of generating increased annual income perpetually to support more research. The support opportunities include: 1. Legacy gifts, such as estate planning, single premium life insurance and charitable lead annuity trusts (CLATs), are meaningful ways to create continuous and sustainable growth for the Foundation in the years and decades to come. 2. Committing to a five-year pledge with an annual donation provides the Foundation income in the present and assists us in budgeting several years out. We will be launching a Future in Five campaign with a generous but critical pledge of $5,000/annually. This pledge level entitles one to Centurion Club level membership for life. 3. General Donations and Centurion Club membership: Any donation from AHNS members and general public alike provides immediate support and is always appreciated. All gifts of $1,000 or more (including pledge gifts) are considered Centurion Club level donations. To make your donation today, please go online to www.ahnsfoundation.info/donations or you may complete a donation form available at the AHNS registration desk. Please contact Kelly Honecker at [email protected] with any questions. The future of the Foundation is bright and your support brings great promise to head and neck cancer research. Thank you! Sincerely, Jatin P. Shah, MD Doug Girod, MD Foundation Chair AHNS President WELCOME Who: The American Head & Neck Society 2015 Translational Research Meeting on Transforming What: Patient Care Through Innovative Research When: April 21-22, 2015 Where: Sheraton Boston Hotel 2015 TRANSLATIONAL RESEARCH 39 Dalton Street MEETING EXHIBITORS Boston, MA 02199 Thank you to our 2015 exhibiting companies! The American Head and Neck Society (AHNS) CONTACT: 11300 W. Olympic Blvd., Suite 600 Genzyme, a Sanofi Company Los Angeles, CA 90064 Novadaq Via phone: +1-310-437-0559 Synovis Micro Companies Alliance Via fax: +1-310-437-0585 Veracyte, Inc. Via email: [email protected] www.ahns.info TABLE OF CONTENTS General Information 2 About the American Head & Neck Society 3 Program Leadership 4 Keynote Lecturers 5 AHNS Accreditation 6 Commercial Bias Reporting Form 7 Sheraton Boston Hotel Floorplan 8 Scientific Program 9 Faculty Listing 18 Faculty & Presenter Disclosures 20 Oral Papers 22 Poster Listing 32 AHNS 2015 TRANSLATIONAL RESEARCH MEETING 1 ON-SITE REGISTRATION HOURS General information Location: Constitution Ballroom Foyer Monday, April 20 12:00 PM - 6:00 PM TRANSLATIONAL RESEARCH MEETING EDUCATIONAL OBJECTIVES Tuesday, April 21 7:00 AM - 6:00 PM At the conclusion of the activity, participants will be able to: Wednesday, April 22 7:30 AM - 7:00 PM • Integrate molecular testing for HPV and other HNSCC subtypes into practice and/or trial design EXHIBIT AREA HOURS Location: Back Bay Ballroom • Understand that massive sequencing and molecular data exists and use this data to form Tuesday, April 21 12:00 PM - 3:30 PM hypotheses, to design pre-clinical experiments and to translate results into clinical trials 5:00 PM - 6:00 PM • Be aware of existing and developing technology for minimally invasive surgery and Wednesday, April 22 10:00 AM - 3:00 PM implement currently available tools for care of patients 6:00 PM - 7:00 PM • Recognize existing best practices based on outcome studies and integrate them into current multi-disciplinary practices at their institutions or practices POSTER SCHEDULE & VIEWING HOURS • Assess the potential value of immuno-modulatory and combinatorial targeted therapy in Location: Back Bay Ballroom HNSCC based on progress made with other tumor types and participate in pre-clinical or Tuesday, April 21 clinical research to increase understanding of these therapies for HNSCC Poster Set-Up Hours 10:00 AM - 11:30 AM RESEARCH MEETING CME CREDIT CLAIM PROCESS Poster Display Hours 12:00 PM - 3:30 PM Opening Reception 5:00 PM - 6:00 PM Please use the worksheet on page 6 to track the number of CME hours you attend for each activity. After the meeting, an email will be sent to attendees with an on-line link to the survey Wednesday, April 22 and claim form. Poster Display Hours 10:00 AM - 3:00 PM AHNS has instituted a new process for claiming CME credits and printing certificates. All Poster Reception 6:00 PM - 7:00 PM attendees wishing to receive a CME certificate for activities attended at the AHNS 2015 Poster Breakdown Time 7:00 PM - 9:00 PM Translational Research Meeting must first complete an on-line meeting evaluation form. Attendees will have access to the on-line meeting evaluation and credit claim form via a link on SPEAKER READY INSTRUCTIONS the AHNS website after the meeting. All speakers must have their PPT presentation Please allow 4-6 weeks for processing before your certificate arrives. uploaded 2 hours before their presentation. Please check in your presentation at the AV table in the Constitution Foyer located right outside Constitution Ballroom. VISIBILITY DONORS Thank you to our 2015 Visibility Donors! The following companies have provided generous support for non-CME meeting activities: Platinum Donor Medrobotics Corporation Gold Donor IRX Therapeutics, Inc. AHNS 2015 TRANSLATIONAL RESEARCH MEETING 2 TRANSLATIONAL RESEARCH ABOUT AHNS MEETING PLANNING COMMITTEE Wendell G. Yarbrough, MD, MMHC, FACS HISTORY OF THE SOCIETY Program Chair M. Boyd Gillespie, MD, MS On May 13, 1998, The American Head and Neck Society (AHNS) became the single largest Program Co-Chair organization in North America for the advancement of research and education in head and neck oncology. The merger of two societies, the American Society for Head and Neck Surgery and Benjamin Judson, MD the Society of Head and Neck Surgeons, formed the American Head and Neck Society. Poster Chair The contributions made by the two societies forming the AHNS are significant in the history Nishant Agarwal, MD of surgery in the United States. Dr. Hayes Martin conceived the Society of Head and Neck Surgeons in 1954, a surgeon considered by many to be the “father of modern head and Joseph A. Califano, MD neck tumor surgery.” The purpose of the society was to exchange and advance the scientific knowledge relevant to the surgery of head and neck tumors (exclusive of brain surgery) with Christine G. Gourin, MD an emphasis on cancer of the head and neck. Two years later, The American Society for Head and Neck Surgery was organized with the goal to “facilitate and advance knowledge relevant to Chris Holsinger, MD surgical treatment of diseases of the head and neck, including reconstruction and rehabilitation; Eduardo Mendez, MD promote advancement of the highest professional and ethical standards as they pertain to the practice of major head and neck surgery; and to honor those who have made major Gregory L. Randolph, MD contributions in the field of head and neck surgery, or have aided in its advancement”. The new Society remains dedicated to the common goals of its parental organizations. James Rocco, MD, PhD Eben Rosenthal, MD MISSION STATEMENT John Sunwoo, MD The purpose of this society is to promote and advance the knowledge of prevention, diagnosis, treatment and rehabilitation of neoplasms and other diseases of the head and neck, to promote Adam M. Zanation, MD and advance research in diseases of the head and neck, and to promote and advance the highest professional and ethical standards. WHY JOIN THE AHNS? The American Head and Neck Society is an organization of physicians, scientists and allied health professionals dedicated to improving the understanding of Head and Neck Cancer and the care of patients afflicted with that disease. Membership is open to a wide variety of interested individuals in several categories that differ both in terms of responsibility and level of involvement in the society. For more information about AHNS membership and to apply on-line, please visit www.ahns.info/member-central or call +1 310-437-0559, ext. 156. AHNS 2015 TRANSLATIONAL RESEARCH MEETING 3 Program LEADERS PROGRAM CHAIR PROGRAM CO-CHAIR Wendell G. Yarbrough, MD, MMHC, FACS M. Boyd Gillespie, MD, MSC Dr. Yarbrough graduated in 1989 from UNC School of Medicine with M. Boyd Gillespie, honors and distinction after graduating from UNC as a Morehead MD, MSc, is Scholar. Otolaryngology residency and a surgical oncology fellowship, professor of then a faculty position, K08, then R01 funding followed while at UNC. In otolaryngology- 2003, Dr. Yarbrough relocated to Vanderbilt as leader of the Barry Baker head and neck Laboratory for H&N Cancer where he was Co-Leader of the Thoracic/ surgery and H&N Program and helped form the Tennessee Chapter of the Head and vice-chairman of Neck Cancer Alliance.