ROLE OF HEALTH ECONOMIC DATA IN POLICY MAKING AND REIMBURSEMENT OF NEW MEDICAL TECHNOLOGIES EDITED BY : Mihajlo (Michael) Jakovljevic and Tetsuji Yamada PUBLISHED IN : Frontiers in Pharmacology Frontiers Copyright Statement About Frontiers © Copyright 2007-2017 Frontiers Media SA. All rights reserved. Frontiers is more than just an open-access publisher of scholarly articles: it is a pioneering All content included on this site, approach to the world of academia, radically improving the way scholarly research such as text, graphics, logos, button icons, images, video/audio clips, is managed. The grand vision of Frontiers is a world where all people have an equal downloads, data compilations and software, is the property of or is opportunity to seek, share and generate knowledge. Frontiers provides immediate and licensed to Frontiers Media SA permanent online open access to all its publications, but this alone is not enough to (“Frontiers”) or its licensees and/or subcontractors. The copyright in the realize our grand goals. text of individual articles is the property of their respective authors, subject to a license granted to Frontiers. Frontiers Journal Series The compilation of articles constituting The Frontiers Journal Series is a multi-tier and interdisciplinary set of open-access, online this e-book, wherever published, as well as the compilation of all other journals, promising a paradigm shift from the current review, selection and dissemination content on this site, is the exclusive processes in academic publishing. All Frontiers journals are driven by researchers for property of Frontiers. For the conditions for downloading and researchers; therefore, they constitute a service to the scholarly community. At the same copying of e-books from Frontiers’ website, please see the Terms for time, the Frontiers Journal Series operates on a revolutionary invention, the tiered publishing Website Use. If purchasing Frontiers system, initially addressing specific communities of scholars, and gradually climbing up to e-books from other websites or sources, the conditions of the broader public understanding, thus serving the interests of the lay society, too. website concerned apply. Images and graphics not forming part Dedication to Quality of user-contributed materials may not be downloaded or copied Each Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative without permission. Individual articles may be downloaded interactions between authors and review editors, who include some of the world’s best and reproduced in accordance academicians. Research must be certified by peers before entering a stream of knowledge with the principles of the CC-BY licence subject to any copyright or that may eventually reach the public - and shape society; therefore, Frontiers only applies other notices. They may not be the most rigorous and unbiased reviews. re-sold as an e-book. As author or other contributor you Frontiers revolutionizes research publishing by freely delivering the most outstanding grant a CC-BY licence to others to research, evaluated with no bias from both the academic and social point of view. reproduce your articles, including any graphics and third-party materials By applying the most advanced information technologies, Frontiers is catapulting scholarly supplied by you, in accordance with the Conditions for Website Use and publishing into a new generation. subject to any copyright notices which you include in connection with your What are Frontiers Research Topics? articles and materials. All copyright, and all rights therein, Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: are protected by national and international copyright laws. they are collections of at least ten articles, all centered on a particular subject. With their The above represents a summary unique mix of varied contributions from Original Research to Review Articles, Frontiers only. For the full conditions see the Research Topics unify the most influential researchers, the latest key findings and historical Conditions for Authors and the Conditions for Website Use. advances in a hot research area! Find out more on how to host your own Frontiers ISSN 1664-8714 Research Topic or contribute to one as an author by contacting the Frontiers Editorial ISBN 978-2-88945-320-7 DOI 10.3389/978-2-88945-320-7 Office:[email protected] Frontiers in Pharmacology 1 November 2017 | Health Economics–Novel Medical Technologies ROLE OF HEALTH ECONOMIC DATA IN POLICY MAKING AND REIMBURSEMENT OF NEW MEDICAL TECHNOLOGIES Topic Editors: Mihajlo (Michael) Jakovljevic, University of Kragujevac, Serbia; Center for Health Trends and Forecasts (IHME) at the University of Washington, United States Tetsuji Yamada, Rutgers University, The State University of New Jersey, United States This Research Topic was focused on provision of novel medical technologies worldwide keeping in mind financial sustainability challenge. An exemplary area certainly are oncology pharmaceu- ticals where prices have increased 10-fold in recent years leading to concerns on affordability. The objective of this collection of studies was to reveal some of the hidden underlying causes of unequal access to the medicines. Another core issue is the growing proportion of out-of- pocket health spending in many world regions. In line with the joint efforts of the editors and authors we received an exceptionally high response worldwide. This E-Book attracted a total of 37 self-standing research submissions out of which 32 ultimately passed external peer review and got published. Base affiliations of the authors spread across academia, pharmaceutical and medical device industry, governmental authorities and clinical medicine. Their home institutions were situated in fifteen different countries inclusive of Japan, Israel, Russia, USA, Germany, Italy, Netherlands, Austria, Spain, Malta, Serbia, Poland, Bulgaria, Hungary and Malaysia. We frankly believe that authors succeeded to cover important literature gaps referring to these world regions. We solicit global professional audience to put our efforts to the test and read this contribution to the health economics literature. Citation: Jakovljevic, M., Yamada, T., eds. (2017). Role of Health Economic Data in Policy Making and Reimbursement of New Medical Technologies. Lausanne: Frontiers Media. doi: 10.3389/978-2-88945-320-7 Frontiers in Pharmacology 2 November 2017 | Health Economics–Novel Medical Technologies Table of Contents 06 Editorial: Role of Health Economic Data in Policy Making and Reimbursement of New Medical Technologies Mihajlo Jakovljevic and Tetsuji Yamada 10 Growth of Global Health Spending Share in Low and Middle Income Countries Mihajlo Jakovljevic and Thomas E. Getzen 14 Economic Evaluation in Stratified Medicine: Methodological Issues and Challenges Hans-Joerg Fugel, Mark Nuijten, Maarten Postma and Ken Redekop 21 Analysis of Regional Variation in the Scope of Eligibility Defined by Ages in Children’s Medical Expense Subsidy Program in Japan Takuma Sugahara 28 Is the Comparison between Exercise and Pharmacologic Treatment of Depression in the Clinical Practice Guideline of the American College of Physicians Evidence-Based? Yael Netz 37 Alcohol Beverage Household Expenditure, Taxation and Government Revenues in Broader European WHO Region Mihajlo Jakovljevic, Elena A. Varavikova, Henriette Walter, Alexander Wascher, Ana V. Pejcic and Otto M. Lesch 46 Observed and Normative Discount Functions in Addiction and other Diseases Salvador Cruz Rambaud, María J. Muñoz Torrecillas and Taiki Takahashi 56 Health Economic Data in Reimbursement of New Medical Technologies: Importance of the Socio-Economic Burden as a Decision-Making Criterion Georgi Iskrov, Svetlan Dermendzhiev, Tsonka Miteva-Katrandzhieva and Rumen Stefanov 61 Overcoming Barriers to the Market Access of Biosimilars in the European Union: The Case of Biosimilar Monoclonal Antibodies Evelien Moorkens, Clara Jonker-Exler, Isabelle Huys, Paul Declerck, Steven Simoens and Arnold G. Vulto 70 The Systemic Changes to Improve Efficiency in Polish Primary Health Care Tomasz Holecki, Piotr Romaniuk and Joanna Woz’niak-Holecka 75 The Life Cycle of Health Technologies. Challenges and Ways Forward Iñaki Gutiérrez-Ibarluzea, Marco Chiumente and Hans-Peter Dauben 79 The New and Old Europe: East-West Split in Pharmaceutical Spending Mihajlo Jakovljevic, Marija Lazarevic, Olivera Milovanovic and Tatjana Kanjevac 86 The Market of Biopharmaceutical Medicines: A Snapshot of a Diverse Industrial Landscape Evelien Moorkens, Nicolas Meuwissen, Isabelle Huys, Paul Declerck, Arnold G. Vulto and Steven Simoens Frontiers in Pharmacology 3 November 2017 | Health Economics–Novel Medical Technologies 98 Commentary: Comparison of historical medical spending patterns among the BRICS and G7 Sandra C. Buttigieg, Simon Grima and Carl Camilleri 101 Length of Hospital Stay and Bed Occupancy Rates in Former Yugoslav Republics 1989–2015 Aleksandar Cvetkovic, Danijela Cvetkovic, Vladislava Stojic and Nebojsa Zdravkovic 107 Health Promotion Development in the Spa Treatment. Perspectives for the European Countries Learned from Poland’s Experiences Joanna Woz’ niak-Holecka, Piotr Romaniuk, Tomasz Holecki, Aldona Fra˛czkiewicz-Wronka and Sylwia Jaruga 111 Modeling Determinants of Health Expenditures in Malaysia: Evidence from Time Series Analysis Habib N. Khan, Radzuan B. Razali and Afza B. Shafie 118 Perspectives for the Use of Social Media in e-Pharmamarketing