UNODC LEADING THE INTERGRATED GLOBAL RESPONSE TO THE OPIOID CRISIS P I L L A R 1 P I L L A R 2 P I L L A R 3 P I L L A R 4 P I L L A R 5 I N T E R N A T I O N A L L A W S T R E N G T H E N I N G C O U N T E R E A R L Y W A R N I N G A N D R A T I O N A L P R E S C R I B I N G A N D S T R E N G T H E N I N G A N D S U P P O R T I N G E N F O R C E M E N T O P E R A T I O N S N A R C O T I C C A P A C I T Y A N D T R E N D A N A L Y S I S A C C E S S T O O P I O I D S P R E V E N T I O N A N D T R E A T M E N T T O D I S R U P T T R A F F I C K I N G I N T E R N A T I O N A L C O O P E R A T I O N IDENTIFYING THE MOST PREVELANT, PERSISTANT AND HARMFUL SYNTHETIC OPIOIDS U N O D C 282 90 E A R L Y TOXICOLOGY COLLABORATING IN COUNTRIES W A R N I N G INFORMED THREATS LABORATORIES A D V I S O R Y ASSESSMENTS PHARMACOLOGICAL INFORMATION L A B O R A T O R I E S A N D D A T A P O I N T S L A B O R A T O R I E S D A T A P O I N T S G L O B A L S M A R T U P D A T E S 21,400+ 120 DATA POINTS FROM COUNTRIES SYNTHETIC SEDATIVE 74 OPIOIDS HYPNOTICS REPORTED MIRRORING TO UNODC SYNTHETIC E A R L Y OPIOID TRENDS W A R N I N G A D V I S O R Y B Y 2019 131% IN THE LAST * * 3 Y E A R S Note: * 2019 data collection not finalized LIST OF SYNTHETIC OPIOIDS REPORTED TO THE UNODC EWA FROM 2009-2019 S C H E D U L E D 2-Fluorofentanyl Furanylfentanyl 4-Fluorobutyrfentanyl Methoxyacetylfentanyl 4-Fluoroisobutyrfentanyl MT-45 S C H E D U L E I Acrylfentanyl Ocfentanil ( 1 9 6 1 ) AH-7921 Tetrahydrofuranylfentanyl Butyrfentanyl U-47700 S C H E D U L E I & I V Cyclopropylfentanyl ( 1 9 6 1 ) S C H E D U L E I V Acetylfentanyl Carfentanil ( 1 9 7 1 ) Phenazepam U N D E R R E V I E W Crotonylfentanyl Valerylfentanyl Etizolam Flualprazolam NOTE: SUBSTANCES ARE CURRENTLY UNDER REVIEW WITH THE 42ND EXPERT COMMITTEE ON DRUG DEPENDENCE (WHO) N O T C O N T R O L L E D (E)-4-chloro-N-(1-(4-nitrophenethyl)piperidin-2- 4-Methylacetylfentanyl Flunitrazolam ylidene)benzenesulfonamide Acetylbenzylfentanyl Furanyl UF-17 1-Methyl-4-phenyl-4-propionoxypiperidine Acetylnorfentanyl Hexanoylfentanyl 2-[3-(aminomethyl)-5-methyl-4H-1,2,4-triazol-4-yl]-5- Adinazolam (Iso)Butyryfentanyl chlorophenyl-(phenyl)methanone Benzodioxolefentanyl Isopropyl-U-47700 2-ethyl-4-phenyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a] Benzoylbenzylfentanyl Mebroqualone [1,4]diazepine Benzoylfentanyl Meclonazepam 2-Fluorobutyrfentanyl Benzylfentanyl Methyl clonazepam 2-Fluoroisobutyrfentanyl Benzylfuranylfentanyl para-Methylfentanyl 2-Furanylbenzylfentanyl beta-Hydroxythiofentanyl Methylmethaqualone 2-Isopropylfuranylfentanyl Bromadoline Metizolam 2-Methoxyfuranylfentanyl Bromazolam Nifoxipam 2-Methyl-AP-237 Clobromazolam Nitrazolam 2-Methylacetylfentanyl Clonazolam N-Methylnorfentanyl 2-Methylfuranylfentanyl Cloniprazepam N-Methyl U-47931E 2-Thiofuranylfentanyl Clonitrazolam Norfludiazepam 3-Fluorofentanyl Cyclohexyl Fentanyl Piperidylthiambutene 3-Fluoromethoxyacetylfentanyl Cyclopentylfentanyl Pyrazolam 3-Hydroxyphenazepam Deschloroetizolam Ro-07-4065 3-Methyl-6- Desmethylflunitrazepam Tetramethylcyclopropanefentanyl [3(trifluoromethyl)phenyl]-1,2,4]triazolo[3,4- O-Desmethyltramadol Thienylfentanyl f]pyridazine DONORS Despropionyl 2-fluorofentanyl Thionordazepam 3-Methylcrotonylfentanyl Despropionyl 4- U-48800 3-Phenylpropanoylfentanyl fluorobenzylfentanyl U-50488 3,4-Methylenedioxy-U-47700 Despropionyl 4-fluorofentanyl U-51754 4-Chlorodiazepam Despropionylfentanyl 4-Chlorofuranylfentanyl Diclazepam 4-Chloroisobutyrfentanyl Etaqualone 4-Fluorocyclopropylbenzylfentanyl Flubromazepam Non-fentanyl opioids 4-Fluorofuranylfentanyl4-Hydroxybutyrfentanyl Fubromazolam Fentanyl analogues 4-Methoxybutyrfentanyl Fluclotizolam Sedative hypnotics DONORS COLLABORATORS .