Supplemental Table 1 p<0.05 Human (Hs683) EntrezGene Name shQKI-1/shGFP shQKI-2/shGFP 0 0 26.63 19.00 0 0 11.75 12.75 0 CDNA clone IMAGE:5267346 8.96 4.77 LOC91316: Similar to bK246H3.1 (immunoglobulin lambda-like 91316 polypeptide 1, pre-B-cell specific) 7.94 3.85 RIPK2: receptor-interacting serine- 8767 threonine kinase 2 4.09 3.21 LOC728705: hypothetical protein 728705 LOC728705 3.86 2.44 0 Transcribed locus 3.79 3.95 CCDC57: coiled-coil domain containing 284001 57 3.62 4.73 C1orf101: chromosome 1 open reading 257044 frame 101 3.54 3.33 CDNA FLJ30490 fis, clone 0 BRAWH2000169 3.28 2.76 CHRNE: cholinergic receptor, nicotinic, 1145 epsilon 3.25 2.42 LOC728215: similar to transmembrane 728215 protein 28 3.25 2.86 83849 SYT15: Synaptotagmin XV 3.24 3.30 0 Transcribed locus 3.18 2.64 79838 TMC5: transmembrane channel-like 5 3.16 2.70 144568 A2ML1: alpha-2-macroglobulin-like 1 3.13 2.77 AGGF1: angiogenic factor with G patch 55109 and FHA domains 1 3.09 2.86 91703 ACY3: aspartoacylase (aminocyclase) 3 3.06 2.30 258010 SVIP: small VCP/p97-interacting protein 3.01 2.30 MSR1: macrophage scavenger receptor 4481 1 2.97 2.01 23250 ATP11A: ATPase, class VI, type 11A 2.96 1.71 LOC440934: Hypothetical gene 440934 supported by BC008048 2.89 2.27 0 Transcribed locus 2.87 3.04 Homo sapiens, clone IMAGE:4391558, 0 mRNA 2.85 3.38 C4orf38: chromosome 4 open reading 152641 frame 38 2.79 1.88 54756 IL17RD: interleukin 17 receptor D 2.77 1.98 0 CDNA clone IMAGE:5277449 2.75 2.25 OR51B2: olfactory receptor, family 51, 79345 subfamily B, member 2 2.75 1.89 0 CDNA clone IMAGE:4894320 2.71 3.16 COL4A3: collagen, type IV, alpha 3 1285 (Goodpasture antigen) 2.70 2.73 0 Clone FLB9413 PRO2532 2.69 2.82 MTHFD2L: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2- 441024 like 2.68 2.77 00 2.63 1.76 2778 GNAS: GNAS complex locus 2.59 3.09 0 Clone HQ0097 PRO0097 2.58 1.93 0 Transcribed locus 2.55 2.02 CCDC46: coiled-coil domain containing 201134 46 2.53 1.98 C8orf37: chromosome 8 open reading 157657 frame 37 2.52 1.60 ADAMTS3: ADAM metallopeptidase 9508 with thrombospondin type 1 motif, 3 2.52 2.28 ZCCHC7: zinc finger, CCHC domain 84186 containing 7 2.49 1.94 258010 SVIP: small VCP/p97-interacting protein 2.47 2.97 5332 PLCB4: phospholipase C, beta 4 2.44 2.00 Transcribed locus, moderately similar to XP_512041.1 PREDICTED: similar to Myosin regulatory light chain 2, nonsarcomeric (Myosin RLC) [Pan 0 troglodytes] 2.42 1.63 PACSIN3: protein kinase C and casein 29763 kinase substrate in neurons 3 2.41 1.84 0 0 2.40 2.04 C6orf166: Chromosome 6 open reading 55122 frame 166 2.37 2.06 25796 PGLS: 6-phosphogluconolactonase 2.37 2.13 CDNA FLJ12676 fis, clone 0 NT2RM4002383 2.35 1.90 RTP1: receptor (chemosensory) 132112 transporter protein 1 2.35 2.66 0 Transcribed locus 2.33 1.58 CDNA FLJ31249 fis, clone 0 KIDNE2005327 2.31 2.56 PIGW: phosphatidylinositol glycan 284098 anchor biosynthesis, class W 2.31 1.73 HGF: hepatocyte growth factor 3082 (hepapoietin A; scatter factor) 2.30 1.53 50861 STMN3: stathmin-like 3 2.29 1.82 C21orf135: chromosome 21 open 727701 reading frame 135 2.27 1.86 DYNLRB1: dynein, light chain, roadblock- 83658 type 1 2.24 2.37 ADH1A: alcohol dehydrogenase 1A 124 (class I), alpha polypeptide 2.23 2.00 0 Transcribed locus 2.21 2.20 CHST11: carbohydrate (chondroitin 4) 50515 sulfotransferase 11 2.21 2.25 442367 LOC442367: Hypothetical LOC442367 2.19 1.86 PECR: peroxisomal trans-2-enoyl-CoA 55825 reductase 2.19 1.65 258010 SVIP: small VCP/p97-interacting protein 2.18 2.42 284695 ZNF326: zinc finger protein 326 2.17 1.78 LOC728099: hypothetical protein 728099 LOC728099 2.17 1.93 PAPD5: PAP associated domain 64282 containing 5 2.15 1.82 LOC730051 /// ZNF814: zinc finger 400721 /// protein 814 /// similar to Zinc finger 730051 protein 418 2.13 1.74 0 0 2.13 1.62 FLJ23861: hypothetical protein 151050 FLJ23861 2.12 1.69 CDNA FLJ38746 fis, clone 0 KIDNE2012316 2.10 2.23 23095 KIF1B: kinesin family member 1B 2.10 1.54 ZCCHC6: Zinc finger, CCHC domain 79670 containing 6 2.09 1.66 C20orf23: chromosome 20 open 55614 reading frame 23 2.08 1.69 C11orf70: chromosome 11 open 85016 reading frame 70 2.08 1.57 C21orf86: Chromosome 21 open 257103 reading frame 86 2.07 1.92 GRB2: growth factor receptor-bound 2885 protein 2 2.06 1.80 130399 ACVR1C: activin A receptor, type IC 2.06 1.90 57650 KIAA1524: KIAA1524 2.05 1.72 C6orf134: chromosome 6 open reading 79969 frame 134 2.05 1.58 0 CDNA clone IMAGE:4827547 2.05 2.35 CDNA FLJ30650 fis, clone 0 CTONG2006666 2.03 1.52 ATP7B: ATPase, Cu++ transporting, beta 540 polypeptide 2.03 2.06 SEC24A: SEC24 related gene family, 10802 member A (S. cerevisiae) 2.02 2.05 91750 LIN52: lin-52 homolog (C. elegans) 2.01 1.71 CDNA FLJ30478 fis, clone 0 BRAWH1000167 2.00 1.82 8543 LMO4: LIM domain only 4 1.99 1.60 DPY19L2P2: dpy-19-like 2 pseudogene 349152 2 (C. elegans) 1.99 1.79 0 CDNA clone IMAGE:4841343 1.98 2.29 ARMC10: armadillo repeat containing 83787 10 1.98 1.78 3831 KLC1: kinesin light chain 1 1.97 1.95 SPESP1: sperm equatorial segment 246777 protein 1 1.97 2.04 GNRHR: gonadotropin-releasing 2798 hormone receptor 1.96 1.66 SRD5A1: steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha- 6715 steroid delta 4-dehydrogenase alpha 1) 1.95 1.83 MMP1: matrix metallopeptidase 1 4312 (interstitial collagenase) 1.95 1.61 7690 ZNF131: zinc finger protein 131 1.94 1.57 3202 HOXA5: homeobox A5 1.93 1.90 0 Transcribed locus 1.93 2.39 EFHA2: EF-hand domain family, 286097 member A2 1.91 1.71 GABRR2: gamma-aminobutyric acid 2570 (GABA) receptor, rho 2 1.91 2.33 ARHGAP19: Rho GTPase activating 84986 protein 19 1.90 1.85 0 Transcribed locus 1.90 1.75 ASXL2: additional sex combs like 2 55252 (Drosophila) 1.89 1.85 MGC10981: hypothetical protein 84740 MGC10981 1.89 1.67 SULT1B1: sulfotransferase family, 27284 cytosolic, 1B, member 1 1.89 1.85 FAT4: FAT tumor suppressor homolog 4 79633 (Drosophila) 1.89 1.72 LOC441383: Hypothetical gene 441383 supported by AF086559; BC065734 1.88 1.54 8711 TNK1: tyrosine kinase, non-receptor, 1 1.88 1.58 831 CAST: Calpastatin 1.87 1.51 PAIP1: poly(A) binding protein 10605 interacting protein 1 1.86 1.84 CCRN4L: CCR4 carbon catabolite 25819 repression 4-like (S. cerevisiae) 1.85 1.51 317671 RFESD: Rieske (Fe-S) domain containing 1.84 1.81 METT10D: methyltransferase 10 79066 domain containing 1.84 1.90 155185 AMZ1: archaemetzincin-1 1.83 1.52 SCML1: sex comb on midleg-like 1 6322 (Drosophila) 1.82 1.89 84295 PHF6: PHD finger protein 6 1.82 1.92 7156 TOP3A: topoisomerase (DNA) III alpha 1.82 1.89 FBXL16: F-box and leucine-rich repeat 146330 protein 16 1.82 2.01 MMD2: monocyte to macrophage 221938 differentiation-associated 2 1.81 1.50 0 Transcribed locus 1.80 1.56 0 0 1.80 2.21 MAGI1: membrane associated guanylate kinase, WW and PDZ domain 9223 containing 1 1.79 1.87 4163 MCC: mutated in colorectal cancers 1.79 1.67 0 0 1.79 1.72 GEN1: Gen homolog 1, endonuclease 348654 (Drosophila) 1.79 1.56 JAK3: Janus kinase 3 (a protein tyrosine 3718 kinase, leukocyte) 1.78 1.92 STAU2: staufen, RNA binding protein, 27067 homolog 2 (Drosophila) 1.78 1.77 140883 ZNF280B: zinc finger protein 280B 1.78 1.77 54813 KLHL28: kelch-like 28 (Drosophila) 1.77 1.73 6876 TAGLN: transgelin 1.77 0.57 23250 ATP11A: ATPase, class VI, type 11A 1.76 2.07 MASTL: microtubule associated 84930 serine/threonine kinase-like 1.76 1.82 LOC647597 /// SETD8: SET domain containing (lysine methyltransferase) 8 /// similar to Histone-lysine N- methyltransferase, H4 lysine-20 specific (Histone H4-K20 methyltransferase) (H4- K20-HMTase) (SET domain-containing 387893 /// protein 8) (PR/SET domain-containing 647597 protein 07) (PR/SET07) (PR-Set7) 1.76 1.65 26292 MYCBP: c-myc binding protein 1.76 1.54 CHORDC1: cysteine and histidine-rich 26973 domain (CHORD)-containing 1 1.75 1.51 RSBN1L: round spermatid basic protein 222194 1-like 1.75 1.62 PABPN1: poly(A) binding protein, 8106 nuclear 1 1.74 1.57 RP11-298P3.3: phosphonoformate 10443 immuno-associated protein 5 1.74 1.59 56 ACRV1: acrosomal vesicle protein 1 1.74 1.94 CDNA FLJ41018 fis, clone 0 UTERU2018881 1.74 1.58 0 Transcribed locus 1.73 1.71 GAS5 /// SNORD79: small nucleolar 26770 /// RNA, C/D box 79 /// growth arrest- 60674 specific 5 1.73 1.63 1376 CPT2: carnitine palmitoyltransferase II 1.73 1.74 0 CDNA: FLJ22073 fis, clone HEP11868 1.72 1.56 10005 ACOT8: Acyl-CoA thioesterase 8 1.72 1.56 NTRK2: neurotrophic tyrosine kinase, 4915 receptor, type 2 1.72 1.69 SKP2: S-phase kinase-associated protein 6502 2 (p45) 1.71 1.50 93323 NY-SAR-48: sarcoma antigen NY-SAR-48 1.71 1.61 84324 CIP29: cytokine induced protein 29 kDa 1.71 1.70 CHEK1: CHK1 checkpoint homolog (S.