Vipin Chandra Kalia Editor Quorum Sensing vs Quorum Quenching: A Battle with No End in Sight Quorum Sensing vs Quorum Quenching: A Battle with No End in Sight Vipin Chandra Kalia Editor Quorum Sensing vs Quorum Quenching: A Battle with No End in Sight 123 Editor Vipin Chandra Kalia Microbial Biotechnology and Genomics CSIR-Institute of Genomics and Integrative Biology Delhi, India ISBN 978-81-322-1981-1 ISBN 978-81-322-1982-8 (eBook) DOI 10.1007/978-81-322-1982-8 Springer New Delhi Heidelberg New York Dordrecht London Library of Congress Control Number: 2014947883 © Springer India 2015 This work is subject to copyright. 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Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) Preface Human beings encounter scenarios where they develop severe symptoms of a disease. The discovery of antibiotics was thought to relieve human beings of their miseries caused by microbial infections. However, microbes have been evolving rapidly to become resistant to antibiotics. It has been realized that bacteria have a unique system of multiplying silently through the phenomenon termed Quorum Sensing (QS). QS operates through signal molecules, which enable bacteria to sense their population density. At high cell density, bacteria activate their arsenal of virulence factors. QS mediated biofilms formed by pathogenic bacteria allow them to with stand high doses of antibiotics. This provoked scientist to look for novel alternatives to antibiotics. It led to the discovery of QS inhibitors, both natural and synthetic. Recent studies have indicated that QSIs may meet the same fate as antibiotics. Although a lot of scientific literature is being published rapidly since the last few years, it is limited largely to scientific research journals. A compilation of these important findings is not available to students at graduate and post-graduate levels. The best thing about this book is that the various chapters have been written by experts in the respective areas. As it demands tremendous and dedicated effort, we are extremely thankful to all the authors for their prompt responses and their contributions. I was inspired by my parents (Mr. R.B. Kalia and Mrs. Kanta Kalia), wife (Amita), Sunita (Sister), Ravi and Satyendra (Brothers), children (Daksh and Bhrigu), teachers, and Rup and Hemant (friends) to write this book. Throughout the preparation of this work, I was supported by Mr. Prasun Kumar, my Ph.D. student. Delhi, India Vipin Chandra Kalia v Contents Microbes: The Most Friendly Beings?.......................... 1 Vipin C. Kalia Part I Quorum Sensing Mediated Processes Evolution of MDRs.......................................... 9 Ashima Kushwaha Bhardwaj and Kittappa Vinothkumar Biofilms: Maintenance, Development, and Disassembly of Bacterial Communities Are Determined by QS Cascades ...... 23 Hadas Ganin, Eliane Hadas Yardeni, and Ilana Kolodkin-Gal Quorum Sensing in Pathogenesis and Virulence................. 39 Pragasam Viswanathan, Suneeva S.C., and Prasanth Rathinam Quorum Sensing in Nitrogen Fixation.......................... 51 Jie Gao, Anzhou Ma, Xuliang Zhuang, and Guoqiang Zhuang Quorum Sensing in Competence and Sporulation ............... 61 Navneet Rai, Rewa Rai, and K.V. Venkatesh How Important Is the Absolute Configuration to Bacteria Quorum Sensing and Quorum Quenching?............................. 65 Francisca Diana da Silva Araújo, Armando Mateus Pomini, and Anita Jocelyne Marsaioli Part II Quorum Sensing Systems in Microbes Quorum-Sensing Systems in Pseudomonas...................... 73 Jamuna Bai Aswathanarayan and V. Ravishankar Rai Quorum Sensing in Escherichia coli: Interkingdom, Inter- and Intraspecies Dialogues, and a Suicide-Inducing Peptide ...... 85 Bloom-Ackermann Zohar and Ilana Kolodkin-Gal Quorum Sensing in Acinetobacter baumannii ................... 101 Nidhi Bhargava, Prince Sharma, and Neena Capalash Quorum Sensing Systems in Aeromonas spp..................... 115 Weihua Chu, Wei Zhu, and Xiyi Zhuang vii viii Contents Rhizobial Extracellular Signaling Molecules and Their Functions in Symbiotic Interactions with Legumes........................ 123 Walter Giordano Quorum Sensing Systems in Clostridia......................... 133 Charles Darkoh and Godfred Ameyaw Asiedu Quorum-Sensing Systems in Enterococci....................... 155 Ravindra Pal Singh and Jiro Nakayama Quorum-Sensing Systems in Bacillus.......................... 165 Lalit K. Singh, Neha Dhasmana, and Yogendra Singh Part III Detectors for Quorum Sensing Signals Quorum Sensing Biosensors.................................. 173 Navneet Rai, Rewa Rai, and K.V. Venkatesh Caenorhabditis elegans as an In Vivo Non-Mammalian Model System to Study Quorum Sensing in Pathogens ................. 185 Sajal Sarabhai, Neena Capalash, and Prince Sharma Strategies for Silencing Bacterial Communication............... 197 Kristina Ivanova, Margarida M. Fernandes, and Tzanko Tzanov Part IV Natural Quorum Sensing Inhibitors Silencing Bacterial Communication Through Enzymatic Quorum-Sensing Inhibition................................... 219 Manuel Romero, Celia Mayer, Andrea Muras, and Ana Otero Fungal Quorum Sensing Inhibitors............................ 237 Rohit Sharma and Kamlesh Jangid Marine Organisms as Source of Quorum Sensing Inhibitors ...... 259 Fohad Mabood Husain and Iqbal Ahmad Plant Quorum Sensing Inhibitors: Food, Medicinal Plants, and Others.................................................. 269 Pragasam Viswanathan, Prasanth Rathinam, and Suneeva S.C. Part V Synthetic Quorum Sensing Inhibitors Synthetic Quorum Sensing Inhibitors: Signal Analogues ......... 285 Dimpy Kalia Synthetic Quorum Sensing Inhibitors (QSIs) Blocking Receptor Signaling or Signal Molecule Biosynthesis in Pseudomonas aeruginosa.................................................. 303 Christine K. Maurer, Cenbin Lu, Martin Empting, and Rolf W. Hartmann Contents ix Development of Quorum-Sensing Inhibitors Targeting the fsr System of Enterococcus faecalis............................... 319 Ravindra Pal Singh and Jiro Nakayama Part VI Alternative Strategies as Quorum Sensing Inhibitors An Alternative Strategy as Quorum-Sensing Inhibitor: Pheromone-Guided Antimicrobial Peptides..................... 327 Yung-Hua Li and Xiao-Lin Tian Alternative Strategies to Target Quorum Sensing (QS): Combination of QS Inhibitors with Antibiotics and Nanotechnological Approaches............................ 335 Divakara S.S.M. Uppu, Chandradhish Ghosh, and Jayanta Haldar Heterologous Expression of Quorum Sensing Inhibitory Genes in Diverse Organisms........................................ 343 Prasun Kumar, Shikha Koul, Sanjay K.S. Patel, Jung-Kul Lee, and Vipin C. Kalia Part VII Biotechnological Applications of Quorum Sensing Inhibitors Potential Applications of Quorum Sensing Inhibitors in Diverse Fields...................................................... 359 Vipin C. Kalia and Prasun Kumar Biotechnological Applications of Quorum-Sensing Inhibitors in Aquacultures............................................. 371 Faseela Hamza, Ameeta Ravi Kumar, and Smita Zinjarde The Battle: Quorum-Sensing Inhibitors Versus Evolution of Bacterial Resistance....................................... 385 Vipin C. Kalia and Prasun Kumar About the Editor Dr. Vipin Chandra Kalia is presently working as Chief Scientist, Microbial Biotechnology and Genomics, CSIR-Institute of Genomics and Integrative Biology, Delhi. He is a Professor, AcSIR who obtained his M.Sc. and Ph.D. in Genetics, from Indian Agricultural Research Institute, New Delhi. He has been elected as: (1) Fellow of the Association of Microbiologists of India (FAMI), and (2) Fellow of the National Academy of Sciences (FNASc). His main areas of research are microbial biodiversity, bioenergy, biopolymers, genomics, microbial evolution, quorum sensing, quorum quenching, drug discovery