Table S2 Differentially expressed genes between oncogene-introduced wild-type and Atf4-/- cells GeneSymbol Gene Name Zscore ratio Genbank Accession Cfd complement factor D 12.714 25036.184 NM_013459 Saa3 serum amyloid A 3 11.189 7437.106 NM_011315 Hp haptoglobin 10.836 5613.776 NM_017370 Prl2c5 prolactin family 2, subfamily c, member 5 7.688 92.732 NM_181852 Cidec cell death-inducing DFFA-like effector c 7.611 982.214 NM_178373 Nrap nebulin-related anchoring protein 7.569 945.372 NM_008733 Adipoq adiponectin, C1Q and collagen domain containing 7.563 940.547 NM_009605 C3 complement component 3 7.310 339.287 NM_009778 Trim12a tripartite motif-containing 12A 7.214 685.215 NM_023835 Apoc1 apolipoprotein C-I 7.026 270.661 NM_007469 Saa1 serum amyloid A 1 6.880 77.790 NM_009117 Lcn2 lipocalin 2 6.658 201.906 NM_008491 Ddx3y DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked 6.620 400.047 NM_012008 Pxt1 peroxisomal, testis specific 1 6.470 349.122 NM_153390 Dll4 delta-like 4 6.455 344.263 NM_019454 Lrg1 leucine-rich alpha-2-glycoprotein 1 6.398 326.917 NM_029796 Dcn decorin 6.335 41.800 NM_007833 Rarres2 retinoic acid receptor responder (tazarotene induced) 2 5.985 118.167 NM_027852 Ccl2 chemokine (C-C motif) ligand 2 5.980 12.764 NM_011333 Cyp2f2 cytochrome P450, family 2, subfamily f, polypeptide 2 5.944 584.071 NM_007817 Ccl11 chemokine (C-C motif) ligand 11 5.936 579.003 NM_011330 Plin1 perilipin 1 5.846 198.287 NM_175640 Gsta3 glutathione S-transferase, alpha 3 5.842 105.447 NM_001077353 Barx2 BarH-like homeobox 2 5.836 40.178 NM_013800 Gpd1 glycerol-3-phosphate dehydrogenase 1 5.761 98.835 NM_010271 Fabp4 fatty acid binding protein 4, adipocyte 5.667 28.197 NM_024406 Ifi27l2a interferon, alpha-inducible protein 27 like 2A 5.665 91.632 NM_029803 Eif2s3y eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked 5.562 153.234 NM_012011 Mnda myeloid cell nuclear differentiation antigen 5.513 368.786 NM_001033450 Prl2c1 Prolactin family 2, subfamily c, member 1 5.478 25.230 NM_001045532 Plin4 perilipin 4 5.412 30.703 NM_020568 Trf transferrin 5.145 60.553 NM_133977 Klra2 killer cell lectin-like receptor, subfamily A, member 2 5.046 223.985 NM_001170851 Cfb complement factor B 5.043 95.684 NM_008198 Dpt dermatopontin 5.001 92.155 NM_019759 Brs3 bombesin-like receptor 3 4.985 209.917 NM_009766 Fth1 ferritin heavy chain 1 4.961 3.041 NM_010239 C1s complement component 1, s subcomponent 4.890 49.443 NM_144938 Angptl4 angiopoietin-like 4 4.853 21.563 NM_020581 Pdpn podoplanin 4.852 17.453 NM_010329 Tmem14c transmembrane protein 14C 4.782 45.344 NM_025387 Cp ceruloplasmin 4.759 44.548 NM_007752 Il4ra interleukin 4 receptor, alpha 4.750 73.367 NM_001008700 Cck cholecystokinin 4.734 7.486 NM_031161 Tmem176b transmembrane protein 176B 4.725 7.458 NM_023056 Vstm2a V-set and transmembrane domain containing 2A 4.687 152.663 NM_145967 Ccl7 chemokine (C-C motif) ligand 7 4.614 7.112 NM_013654 Snhg11 small nucleolar RNA host gene 11 4.531 129.291 NM_175692 Tekt5 tektin 5 4.531 129.200 NM_001099275 Gstm6 glutathione S-transferase, mu 6 4.438 55.291 NM_008184 Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein 4.437 13.666 NM_011150 Mefv Mediterranean fever 4.433 55.046 NM_019453 Cxcl1 chemokine (C-X-C motif) ligand 1 4.425 16.435 NM_008176 Thrsp thyroid hormone responsive SPOT14 homolog 4.414 114.129 NM_009381 Islr immunoglobulin superfamily containing leucine-rich repeat 4.396 33.351 NM_012043 Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 4.351 32.181 NM_008115 Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic 4.348 106.318 NM_011044 Penk preproenkephalin 4.339 15.570 NM_001002927 Ces2e carboxylesterase 2E 4.324 31.510 NM_172759 Acyp2 acylphosphatase 2, muscle type 4.321 49.721 NM_029344 Ifi27l1 interferon, alpha-inducible protein 27 like 1 4.310 12.680 NM_026790 Grin3b glutamate receptor, ionotropic, NMDA3B 4.304 48.978 NM_130455 Samd4 sterile alpha motif domain containing 4 4.251 29.733 NM_001037221 Gdf10 growth differentiation factor 10 4.246 46.446 NM_145741 Caskin2 CASK-interacting protein 2 4.220 14.441 NM_080643 Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B 4.183 14.104 NM_201410 Ly6g lymphocyte antigen 6 complex, locus G 4.180 28.082 XM_001475753 Tmem45b transmembrane protein 45b 4.178 88.645 NM_144936 Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 4.145 85.624 NM_178405 Grem1 gremlin 1 4.099 11.198 NM_011824 Ccl8 chemokine (C-C motif) ligand 8 4.088 26.107 NM_021443 Cdkn2a cyclin-dependent kinase inhibitor 2A 4.074 11.038 NM_009877 H2-Ab1 histocompatibility 2, class II antigen A, beta 1 4.068 25.690 NM_207105 Mfsd6l major facilitator superfamily domain containing 6-like 4.065 78.602 NM_146004 Fmo2 flavin containing monooxygenase 2 4.041 76.607 NM_018881 Ctsk cathepsin K 4.033 12.829 NM_007802 Mrap melanocortin 2 receptor accessory protein 3.990 36.831 NM_029844 Mmp10 matrix metallopeptidase 10 3.989 24.129 NM_019471 Cidea cell death-inducing DNA fragmentation factor, alpha subunit-like effector A 3.976 36.362 NM_007702 Sepp1 selenoprotein P, plasma, 1 3.976 12.368 NM_001042614 Cox8b cytochrome c oxidase, subunit VIIIb 3.968 70.884 NM_007751 Camp cathelicidin antimicrobial peptide 3.962 35.923 NM_009921 Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid 3.953 69.740 NM_013821 delta-isomerase 6 Aoc3 amine oxidase, copper containing 3 3.950 35.512 NM_009675 Fgf23 fibroblast growth factor 23 3.944 5.338 NM_022657 Retn resistin 3.942 68.952 NM_001204959 Nlrc5 NLR family, CARD domain containing 5 3.929 34.840 NM_001033207 Wdr92 WD repeat domain 92 3.924 11.971 NM_178909 Cpz carboxypeptidase Z 3.900 22.470 NM_153107 Lce1g late cornified envelope 1G 3.897 9.945 NM_025413 Clstn2 calsyntenin 2 3.878 22.092 NM_022319 Idua iduronidase, alpha-L- 3.858 5.147 NM_008325 Tusc5 tumor suppressor candidate 5 3.830 61.160 NM_177709 Uts2d urotensin 2 domain containing 3.821 60.551 NM_198166 Dbp D site albumin promoter binding protein 3.815 21.000 NM_016974 Gvin1 GTPase, very large interferon inducible 1 3.805 20.833 NM_029000 Car8 carbonic anhydrase 8 3.801 59.322 NM_007592 Prl3c1 prolactin family 3, subfamily c, member 1 3.790 58.571 NM_013766 Cpxm1 carboxypeptidase X 1 (M14 family) 3.786 10.967 NM_019696 Snap25 synaptosomal-associated protein 25 3.784 4.985 NM_011428 Slc36a2 solute carrier family 36 (proton/amino acid symporter), member 2 3.778 57.857 NM_153170 Agtr2 angiotensin II receptor, type 2 3.775 30.307 NM_007429 Bst2 bone marrow stromal cell antigen 2 3.755 10.755 NM_198095 Itgam integrin alpha M 3.753 4.919 NM_001082960 Kcng2 potassium voltage-gated channel, subfamily G, member 2 3.742 29.407 NM_001190373 Nrn1 neuritin 1 3.740 19.790 NM_153529 Ftl1 ferritin light chain 1 3.731 4.873 NM_010240 Apoa2 apolipoprotein A-II 3.729 54.913 NM_013474 Pamr1 peptidase domain containing associated with muscle regeneration 1 3.724 19.534 NM_173749 Zfp874a zinc finger protein 874a 3.720 54.366 NM_177712 Ch25h cholesterol 25-hydroxylase 3.717 19.438 NM_009890 Ppp1r3c protein phosphatase 1, regulatory (inhibitor) subunit 3C 3.712 53.933 NM_016854 Unc5a unc-5 homolog A 3.707 28.494 NM_153131 Prdm9 PR domain containing 9 3.702 19.206 NM_144809 Il6 interleukin 6 3.698 19.133 NM_031168 Hexim2 hexamthylene bis-acetamide inducible 2 3.693 4.795 NM_027658 Il23a interleukin 23, alpha subunit p19 3.677 51.918 NM_031252 Cygb cytoglobin 3.668 18.694 NM_030206 Hist1h2ba histone cluster 1, H2ba 3.658 10.117 NM_175663 Serpina3c serine (or cysteine) peptidase inhibitor, clade A, member 3C 3.643 50.071 NM_008458 Spag17 sperm associated antigen 17 3.633 49.580 NM_028892 Tnfrsf18 tumor necrosis factor receptor superfamily, member 18 3.617 26.269 NM_009400 Orm2 orosomucoid 2 3.593 47.499 NM_011016 Mmp3 matrix metallopeptidase 3 3.584 8.272 NM_010809 Cd40 CD40 antigen 3.578 17.394 NM_011611 Glyat glycine-N-acyltransferase 3.557 45.704 NM_145935 Nnmt nicotinamide N-methyltransferase 3.550 17.014 NM_010924 Nrxn2 neurexin II 3.536 16.829 NM_001205234 Ubd ubiquitin D 3.532 44.518 NM_023137 Xdh xanthine dehydrogenase 3.527 16.703 NM_011723 Tmem176a transmembrane protein 176A 3.522 9.279 NM_025326 Lpl lipoprotein lipase 3.520 9.270 NM_008509 Nudt18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 3.498 23.577 NM_153136 Serpina3g serine (or cysteine) peptidase inhibitor, clade A, member 3G 3.485 9.066 NM_009251 Krt222 keratin 222 3.470 7.733 NM_172946 Tmem179 transmembrane protein 179 3.465 15.897 NM_178915 Gpm6b glycoprotein m6b 3.464 15.883 NM_001177956 Gch1 GTP cyclohydrolase 1 3.457 8.909 NM_008102 Bace2 beta-site APP-cleaving enzyme 2 3.427 39.787 NM_019517 Hmox1 heme oxygenase (decycling) 1 3.421 7.514 NM_010442 Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 3.418 7.500 NM_080440 Plin5 perilipin 5 3.415 39.259 NM_001077348 Dnmt3l DNA (cytosine-5-) 3.406 21.700 NM_019448 -methyltransferase 3-like C1ra complement component 1, r subcomponent A 3.397 15.057 NM_023143 C4b complement component 4B (Childo blood group) 3.392 21.417 NM_009780 Ltbp2 latent transforming growth factor beta binding protein 2 3.391 4.212 NM_013589 S100a8 S100 calcium binding protein A8 (calgranulin A) 3.371 21.012 NM_013650 Sult4a1 sulfotransferase family 4A, member 1 3.370 14.743 NM_013873 Trim30a tripartite motif-containing 30A 3.361 37.054 NM_009099 S100b S100 protein, beta polypeptide, neural 3.354 14.556 NM_009115 Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 3.351 36.694 NM_009992 Fgf1 fibroblast growth factor 1 3.341 36.288 NM_010197 C1qtnf7 C1q and