COPS2 Antibody Cat. No.: 28-027 COPS2 Antibody Antibody used in WB on Human, Mouse at 1:200. Specifications HOST SPECIES: Rabbit SPECIES REACTIVITY: Dog, Drosophila, Human, Mouse, Rat, Zebrafish Antibody produced in rabbits immunized with a synthetic peptide corresponding a region IMMUNOGEN: of human COPS2. TESTED APPLICATIONS: ELISA, WB COPS2 antibody can be used for detection of COPS2 by ELISA at 1:312500. COPS2 APPLICATIONS: antibody can be used for detection of COPS2 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000. POSITIVE CONTROL: 1) Cat. No. XBL-10409 - Fetal Liver Tissue Lysate PREDICTED MOLECULAR 52 kDa WEIGHT: September 27, 2021 1 https://www.prosci-inc.com/cops2-antibody-28-027.html Properties PURIFICATION: Antibody is purified by protein A chromatography method. CLONALITY: Polyclonal CONJUGATE: Unconjugated PHYSICAL STATE: Liquid Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% BUFFER: sucrose. CONCENTRATION: batch dependent For short periods of storage (days) store at 4˚C. For longer periods of storage, store STORAGE CONDITIONS: COPS2 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles. Additional Info OFFICIAL SYMBOL: COPS2 ALTERNATE NAMES: COPS2, CSN2, SGN2, ALIEN, TRIP15 ACCESSION NO.: NP_004227 PROTEIN GI NO.: 4759264 GENE ID: 9318 USER NOTE: Optimal dilutions for each application to be determined by the researcher. Background and References COPS2 is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the BACKGROUND: deneddylation of the cullin subunits of SCF-type E3 ligase complexes. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/Ion ChannelSBP. COPS2 is also innvolved in early stage of neuronal differentiation via its interaction with NIF3L1. REFERENCES: 1) Moehren, U., (2004) (er) Nucleic Acids Res. 32 (10), 2995-3004. ANTIBODIES FOR RESEARCH USE ONLY. For additional information, visit ProSci's Terms & Conditions Page. September 27, 2021 2 https://www.prosci-inc.com/cops2-antibody-28-027.html.