Junbai Li Editor Supramolecular Chemistry of Biomimetic Systems Supramolecular Chemistry of Biomimetic Systems Junbai Li Editor Supramolecular Chemistry of Biomimetic Systems 123 Editor Junbai Li Institute of Chemistry, Chinese Academy of Sciences Beijing China ISBN 978-981-10-6058-8 ISBN 978-981-10-6059-5 (eBook) DOI 10.1007/978-981-10-6059-5 Library of Congress Control Number: 2017949116 © Springer Nature Singapore Pte Ltd. 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. 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The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore Preface Molecular biomimetics is an emerging active field and important frontier with interdisciplinary subjects of chemistry, physics, molecular biology, and nanotech- nology. Taking lessons from biology, molecular biomimetic is the attempt to construct new highly ordered supramolecular structures through artificial molecule design and assembly at molecular level, which mimic the structures and functions of a unit or organ in biological systems. It is based on the fact that many biomolecules or bioactive molecules like polysaccharides, lipid, peptide, proteins, and dendrimers can self-assemble into well-defined structures and further to a supramolecular architecture while combining with other organic, inorganic, or metal oxide compounds. The molecular biomimetic approach opens up new avenues for the design and utilization of multifunctional molecular systems with a wide range of applications in nanotechnology and biotechnology. In this book, we present recent achievements in biomimetic systems based on supramolecular chemistry and their potential applications in the biomedical field. These include biomimetic membranes, biomacromolecules supramolecular chemistry, hierarchical organic/inorganic hybrid systems, and molecular assembly of motor proteins. We will show our readers the exciting challenges in this unique research area and we hope to convince them of many new research opportunities. I fell honored to edit this book. I would like to sincerely acknowledge every contributors who have accepted my invitation and taken much time to write the chapters. Dr. Yi Jia has spent a lot of time to organize every chapters and revise the entire book Figures and Tables. She shall be also deeply acknowledged. I am also grateful to all help from the surrounding students. Beijing, China Junbai Li April 2017 v Contents Part I Introduction to Supramolecular Chemistry and Biomimetic Systems 1 Molecular Biomimetics and Molecular Assembly ............... 3 Junbai Li 2 Advantages of Self-assembled Supramolecular Polymers Toward Biological Applications .................................... 9 Michal Halperin-Sternfeld, Moumita Ghosh and Lihi Adler-Abramovich Part II Biomimetic Membranes 3 Nanoarchitectonics of Biomimetic Membranes ................. 39 Katsuhiko Ariga Part III Biomolecules Based Molecular Assembly 4 Polysaccharides-Based Microcapsules ........................ 63 Yi Jia, Xiyun Feng and Junbai Li 5 Hemoglobin-Based Molecular Assembly ...................... 85 Li Duan, Yi Jia and Junbai Li 6 Photosystem II Based Multilayers ........................... 109 Peng Cai, Guangle Li, Jiao Li, Yi Jia, Zhongfeng Zhang and Junbai Li 7 Peptide-Based Supramolecular Chemistry..................... 135 Qianli Zou, Kai Liu, Manzar Abbas and Xuehai Yan 8 Functional Nanomaterials Via Self-assembly Based Modification of Natural Cellulosic Substances ............................ 165 Shun Li, Yuanqing Gu and Jianguo Huang vii viii Contents Part IV Molecular Assembly of Motor Proteins and Artificial Micro-/Nanomotors 9 Directional Transportation of Assembled Molecular Linear Motors ................................................. 205 Ning Zhang and Xiang-Dong Li 10 Reconstitution of Motor Protein ATPase ...................... 237 Mingjun Xuan, Yi Jia and Junbai Li 11 Controlled Molecular Assembly Toward Self-propelled Micro-/ Nanomotors ............................................. 259 Xiankun Lin, Zhiguang Wu and Qiang He Part V Hierarchical Dendrimer, Polyoxometalates Complexes and Inorganic-organic Hybrid Systems 12 Functional Dendrimer-Based Vectors for Gene Delivery Applications ............................................. 285 Lingdan Kong and Xiangyang Shi 13 Polyoxometalates and Their Complexes Toward Biological Application.............................................. 311 Lixin Wu and Jing Liang 14 Inorganic-Organic Hybrid Materials Based on Nanopolyoxometalates..................................... 355 Yitong Wang and Jingcheng Hao About the Editor Junbai Li obtained his Ph.D from the Department of Chemistry, Jilin University in 1992. He was then a postdoctoral fellow at the Interface Department of the Max Planck Institute of Colloids and Interfaces in Germany from 1994–1996. He is currently a professor at the Institute of Chemistry, the Chinese Academy of Sciences. His main research interests are on molecular assemblies of biomimetic systems, self-assembly, biointerfaces, design and synthesis of bioinspired materials with various nanostructures. ix Part I Introduction to Supramolecular Chemistry and Biomimetic Systems Chapter 1 Molecular Biomimetics and Molecular Assembly Junbai Li Abstract Molecular biomimetics is mimicking the structures and functions of biological systems at the molecular scale via molecular assembly of biomolecules or synthetic components. It not only provides experimental models for guiding researches on biological mutation and evolution in organisms, but also opens up new avenues for the design and fabrication of novel functional materials. In this chapter, main contents of individual chapters are briefly introduced to give readers an overview of this book. Keywords Molecular biomimetics Á Layer-by-layer assembly Á Self-assembly Á Biomimetic membranes Á Biomacromolecules Á Motor proteins Á Dendrimer Á Polyoxometalates Biological systems have evolved over millions of years to adapt to nature and develop highly fascinating structures and outstanding performances. Biomimetics, inspired by biological structures and their functions, focused on emulating or duplicating biological systems using biomolecules or synthetic components via diverse approaches. With the rapid developments of molecular biology and nan- otechnology, biomimetics is now entering the molecular scale, that is, molecular biomimetics. The capability of biological molecules to self- and co-assemble into highly ordered nanostructures provides molecular assembly with a novel approach in which well-defined structures and biological functions similar to those existing in nature are produced. Thus, molecular assembly of biomimetic systems opens up new avenues for the design and fabrication of well-defined nanostructures and multifunctional materials with a wide range of applications in nanotechnology and biomedicine. A major advantage of molecular assembly of biomimetic systems is that both biochemical and physical parameters can be controlled precisely. J. Li (&) Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, 100190 Beijing, China e-mail: [email protected] © Springer Nature Singapore Pte Ltd. 2017 3 J. Li (ed.), Supramolecular Chemistry of Biomimetic Systems, DOI 10.1007/978-981-10-6059-5_1 4 J. Li Therefore, it is feasible to utilize biomimetic systems as experimental models for guiding research on biological mutation and evolution in organisms. More importantly, biomimetics is not limited to just copying nature, with the develop- ment of modern biology, scientists can directly utilize biological units themselves to construct new types of systems sometimes as hybrid nanostructured materials. As will be illustrated in this book, natural molecular machines such as motor proteins are integrated into the engineering of active biomimetic systems, as well as the construction of artificial molecular machines via molecular assembly of synthetic components. This book covers practical techniques and potential applications of biomimetic systems based on supramolecular chemistry. It also presents the advantages and an overview of supramolecular chemistry of biomimetic systems that consists