Vanguard Funds Supplement Dated July 23, 2021, to the Statement of Additional Information The boards of trustees of the Vanguard funds (the “Boards”) have elected David Thomas as a trustee of the Boards effective July 22, 2021. Statement of Additional InformationText Changes In the Management of the Fund(s) section under Officers and Trustees, Dr. Thomas is added to the table as follows: Principal Occupation(s) Number of Position(s) Vanguard During the Past FiveYears, Vanguard Funds Held With Funds’Trustee/ Outside Directorships, Overseen by Name,YearofBirth Funds Officer Since and Other Experience Trustee/Officer IndependentTrustees David Thomas Trustee July 2021 President of Morehouse College (2018 – present). 212 (1956) Professor of Business Administration Emeritus at Harvard University (2017 – 2018) and Dean (2011-2016) and Professor of Management at Georgetown University, McDonough School of Business (2016 – 2017). Director of DTE Energy Company (2013 – present). Trustee of Common Fund (2019 – present). © 2021 The Vanguard Group, Inc. All rights reserved. Vanguard Marketing Corporation, Distributor. SAI ALL 072021 Vanguard Quantitative Funds Supplement Dated July 2, 2021, to the Statement of Additional Information Dated January 31, 2021 Important Changes to Vanguard Growth and Income Fund As previously announced, effective at the close of business on July 2, 2021, James P. Stetler will retire from Vanguard and will no longer serve as a co-portfolio manager of Vanguard’s portion of Vanguard Growth and Income Fund (the Fund). Accordingly, all references to Mr. Stetler in the Statement of Additional Information will be deleted in their entirety after that date. Following Mr. Stetler’s retirement, Binbin Guo and Cesar Orosco will remain as the portfolio managers of Vanguard’s portion of the Fund. The Fund’s investment objective, strategies, and policies will remain unchanged. Additionally, effective September 2021, Binbin Guo will retire from Vanguard and will no longer serve as a co-portfolio manager of Vanguard’s portion of the Fund. Following Mr. Guo’s retirement, Cesar Orosco will remain as the sole portfolio manager of Vanguard’s portion of the Fund, and the Fund’s investment objective, strategies, and policies will remain unchanged. © 2021 The Vanguard Group, Inc. All rights reserved. Vanguard Marketing Corporation, Distributor. SAI 093C 072021 Vanguard Quantitative Funds Supplement Dated June 17, 2021, to the Statement of Additional Information Dated January 31, 2021 Important Change to Vanguard Growth and Income Fund Los Angeles Capital Management and Equity Research, Inc. (Los Angeles Capital)—one of the advisors to Vanguard Growth and Income Fund—recently changed its name to Los Angeles Capital Management LLC (Los Angeles Capital). All references to Los Angeles Capital Management and Equity Research, Inc. (Los Angeles Capital) in the Statement of Additional Information are hereby replaced with Los Angeles Capital Management LLC (Los Angeles Capital). © 2021 The Vanguard Group, Inc. All rights reserved. Vanguard Marketing Corporation, Distributor. SAI 093B 062021 Vanguard Quantitative Funds Supplement Dated February 26, 2021, to the Statement of Additional Information Dated January 31, 2021 Important Changes to Vanguard Growth and Income Fund Effective immediately, Cesar Orosco will be added as a co-portfolio manager to Vanguard’s portion of Vanguard Growth and Income Fund (the Fund). James P. Stetler will retire from Vanguard in July 2021 and will no longer serve as a co-portfolio manager for Vanguard’s portion of the Fund. The Fund’s investment objective, strategies, and policies remain unchanged. Statement of Additional InformationText Changes In the Investment Advisory and Other Services section, the following text and table are added under the sub-heading “1. Other Accounts Managed” on page B-40: Total assets in No. of accounts with accounts with No. of performance-based performance-based Portfolio Manager accounts Total assets fees fees Cesar Orosco1 Registered investment companies 7 $74B2 0$0 Other pooled investment vehicles 0 $ 0 0 $0 Other accounts 0 $ 0 0 $0 1 Mr. Orosco began co-managing a portion of the Fund on February 26, 2021. 2 Information provided as of October 31, 2020, and includes Vanguard Growth and Income Fund, which held assets of $10.8 billion as of October 31, 2020. Within the same section, the following text is added under the sub-heading “4. Ownership of Securities” on page B-41: As of October 31, 2020, Mr. Orosco did not own shares of Vanguard Growth and Income Fund. © 2021 The Vanguard Group, Inc. All rights reserved. Vanguard Marketing Corporation, Distributor. SAI 093A 022021 PART B ® VANGUARD QUANTITATIVE FUNDS STATEMENT OF ADDITIONAL INFORMATION January 31, 2021 This Statement of Additional Information is not a prospectus but should be read in conjunction with the Fund’s current prospectus (dated January 31, 2021). To obtain, without charge, a prospectus or the most recent Annual Report to Shareholders, which contains the Fund’s financial statements as hereby incorporated by reference, please contact The Vanguard Group, Inc. (Vanguard). Phone: Investor Information Department at 800-662-7447 Online: vanguard.com TABLE OF CONTENTS Description of theTrust ................................................................................................................................................................................. B-1 Fundamental Policies.................................................................................................................................................................................... B-4 Investment Strategies, Risks, and Nonfundamental Policies.................................................................................................................... B-4 Share Price ..................................................................................................................................................................................................... B-21 Purchase and Redemption of Shares .......................................................................................................................................................... B-22 Management of the Fund ............................................................................................................................................................................. B-23 Investment Advisory and Other Services.................................................................................................................................................... B-36 PortfolioTransactions.................................................................................................................................................................................... B-41 Proxy Voting................................................................................................................................................................................................... B-43 Financial Statements .................................................................................................................................................................................... B-43 Appendix A..................................................................................................................................................................................................... B-44 Appendix B .................................................................................................................................................................................................... B-47 DESCRIPTION OFTHETRUST Vanguard Quantitative Funds (the Trust) currently offers the following fund and share classes (identified by ticker symbol): Share Classes1 Vanguard Fund Investor Admiral Vanguard Growth and Income Fund VQNPX VGIAX 1 Individually, a class; collectively, the classes. The Trust has the ability to offer additional funds or classes of shares. There is no limit on the number of full and fractional shares that may be issued for a single fund or class of shares. B-1 Organization The Trust was organized as a Maryland corporation in 1986 and was reorganized as a Delaware statutory trust in 1998. Prior to its reorganization as a Delaware statutory trust, the Trust was known as Vanguard Quantitative Portfolios, Inc. The Trust is registered with the United States Securities and Exchange Commission (SEC) under the Investment Company Act of 1940 (the 1940 Act) as an open-end management investment company. Vanguard Growth and Income Fund (the Fund) is classified as diversified within the meaning of the 1940 Act. Service Providers Custodian. State Street Bank and Trust Company, One Lincoln Street, Boston, MA 02111, serves as the Fund’s custodian. The custodian is responsible for maintaining the Fund’s assets, keeping all necessary accounts and records of Fund assets, and appointing any foreign subcustodians or foreign securities depositories. Independent Registered Public Accounting Firm. PricewaterhouseCoopers LLP, Two Commerce Square, Suite 1800, 2001 Market Street, Philadelphia, PA 19103-7042, serves as the Fund’s independent registered public accounting firm. The independent registered public accounting firm audits the Fund’s annual financial statements and provides other related services. Transfer and Dividend-Paying Agent. The Fund’s transfer agent and dividend-paying agent is Vanguard, P.O. Box 2600, Valley Forge, PA 19482. Characteristics