Britannica LaunchPacks | The Treatment and Prevention of Disease The Treatment and Prevention of Disease For Grades 6-8 This Pack contains: 5 ARTICLES 4 IMAGES 2 VIDEOS © 2020 Encyclopædia Britannica, Inc. 1 of 61 Britannica LaunchPacks | The Treatment and Prevention of Disease antibiotic Certain medicinal substances have the power to destroy or check the growth of infectious organisms in the body. The organisms can be bacteria, viruses, fungi, or the minuscule animals called protozoa. A particular group of these agents is made up of drugs called antibiotics, from the Greek anti (“against”) and bios (“life”). Some antibiotics are produced from living organisms such as bacteria, fungi, and molds. Others are wholly or in part synthetic—that is, produced artificially. Penicillin is perhaps the best known antibiotic. Its discovery and later development has enabled the medical profession to treat effectively many infectious diseases, including some that were once life-threatening. Antibiotics have revolutionized the treatment of bacterial infections in humans and other animals. They are, however, ineffective against viruses. Penicillium mold is grown in a lab. The mold is the source of penicillin, one of the first and most… Catolla—iStock/Thinkstock Learn about antibiotics. © Open University Antibiosis The general relationship between an antibiotic and an infectious organism is one of antibiosis. This word refers to an association of two organisms in which one is harmed or killed by the other. The relationship between human beings and disease-causing germs is one of antibiosis. If a person is affected by germs, he is the injured organism; if the germ attack is repelled by the body’s defenses, the germs are the injured organisms. When a © 2020 Encyclopædia Britannica, Inc. 2 of 61 Britannica LaunchPacks | The Treatment and Prevention of Disease person’s defense system cannot control antibiosis in its own favor, antibiotics are used to tip the balance toward health. Homeostasis The body’s balance between health and illness is called homeostasis. This largely depends on the relationship of the body to the bacteria with which it lives. For example, bacteria are always present on human skin. When the skin is cut, the bacteria are able to get inside the body and may cause infection. Usually the invading bacteria are destroyed by blood cells called phagocytes and by various actions of the immune system. When there are too many bacteria for the system to handle, or the infected person has a low resistance to infection, illness results and antibiotics are needed to help restore homeostasis. Action of Antibiotics Antibiotics can be bacteriostatic (bacteria stopped from multiplying) or bactericidal (bacteria killed). To perform either of these functions, antibiotics must be brought into contact with the bacteria. It is believed that antibiotics interfere with the surface of bacteria cells, causing a change in their ability to reproduce. Testing the action of an antibiotic in the laboratory shows how much exposure to the drug is necessary to halt reproduction or to kill the bacteria. Although a large amount of an antibiotic taken at one time might kill the bacteria causing an illness, such a dose usually would make the person suffer from illness caused by the drug. Therefore, antibiotics are given in a series of smaller amounts. This assures that the bacteria are either killed or reduced enough in numbers so that the body can repel them. When too little antibiotic is taken, bacteria can often develop methods to protect themselves against it. The next time the antibiotic is needed against these bacteria, it will not be effective. Administering Antibiotics Learn why antibiotics are important and how to prevent their overuse. © American Chemical Society To work against infecting organisms, an antibiotic can be applied externally, such as to a cut on the skin’s surface, or internally, reaching the bloodstream within the body. Antibiotics are made in several forms and given in different ways. Topical. Topical application means “to a local area” such as on the skin, in the eyes, or on the mucous membrane. Antibiotics for topical use are available in the form of powders, ointments, or creams. © 2020 Encyclopædia Britannica, Inc. 3 of 61 Britannica LaunchPacks | The Treatment and Prevention of Disease Oral. Tablets, liquids, and capsules are swallowed. The antibiotic is released in the small intestine to be absorbed into the bloodstream. Troches, or lozenges, are allowed to dissolve in the mouth, where the antibiotic is absorbed through the mucous membrane. Parenteral. Applications outside the intestine are called parenteral. One form is an injection, which can be subcutaneous (under the skin), intramuscular (into a muscle), or intravenous (into a vein). Parenteral administration of an antibiotic is used when a physician requires a strong, quick concentration of the antibiotic in the bloodstream. Manufacture Natural. At one time all antibiotics were made from living organisms. This process, known as biosynthesis, is still used in the manufacture of some antibiotics. It is actually the organisms that manufacture the antibiotic. The people involved merely provide favorable conditions for the organisms to do the work and then they collect the drug. For example, mold organisms are placed in a medium (a substance used for the growth of microorganisms) such as corn steep liquor to which milk sugar has been added. This forms a broth that is put into a tank, which is kept at a temperature of 25 °C (77 °F) and shaken for more than 100 hours. The mold organisms grow rapidly in this warm soup, producing penicillin as they do so. The penicillin is later extracted. Synthetic. All penicillin types have an identical chemical nucleus called a ring. The chemical chain that is attached to the ring is different in each type. By changing the molecules of the chain, scientists devise drugs with potentially different effects on different organisms. Some of these drugs are useful in treating infections, some are not. Pharmaceutical manufacturers now use computer-generated images of the rings and experiment with an endless variety of possible chains. Researchers have developed antibiotics with long half-lives (period of effectiveness), which allow taking the medication once in 24 hours instead of every few hours. The newer antibiotics are also more effective against a wider range of infections than were earlier drugs. Varieties There are dozens of antibiotics. The following are in common use: Penicillins. The various types of penicillins make up a large group of antibacterial antibiotics of which only those from benzyl penicillin are naturally produced from molds. Penicillin G and ampicillin are in this class. Another penicillin, called piperacillin, has been shown to be effective against 92 percent of infections without causing serious side effects. Penicillins are often given in combination with some of the following categories of drugs. Cephalosporins. Similar to the penicillins, cephalosporins are often given when a sensitivity (allergic reaction) to the former is known or suspected in a patient. Cefotaxime sodium is a kind of cephalosporin that is very effective in combating deep infections such as those that occur in bones and those resulting from surgery. Aminoglycoside. Aminoglycosides include streptomycin and neomycin. These drugs are used to treat tuberculosis, bubonic plague, and other infections. Because of potentially serious side effects, such as interference with hearing and their ability to make one sensitive to sunlight, these drugs are given with caution. (All antibiotics are given with care; caution implies more than usual possible negative consequences of drug administration.) © 2020 Encyclopædia Britannica, Inc. 4 of 61 Britannica LaunchPacks | The Treatment and Prevention of Disease Tetracyclines. Tetracyclines are effective against pneumonia, typhus, and other bacteria-caused illness but can harm the function of the liver and kidneys. Tetracycline in a special gel base is used to treat many eye infections. Macrolides. Macrolides are often used in patients who appear to be sensitive to penicillin. Erythromycin is the best known medicine in this group. Polypeptides. The class of antibiotics called polypeptides is quite toxic (poisonous) and is used mostly on the surface of the skin (topically). Bacitracin is in this category. Sulfa Drugs Sulfonamide was the first antimicrobial drug to be used. Sulfa drugs, which are made from chemicals, have largely the same effects as those of the later-developed penicillins. As sulfa drugs can have harmful effects on the kidneys—while being effective against kidney infections—they are always taken with large quantities of water to prevent the formation of drug crystals. Gantrisin is still among the most useful of these sulfa drugs. Other Antimicrobials Other antimicrobials include furazolidone and tritethoprim. The first is used primarily in gastrointestinal infections; the latter, when combined with one of the sulfonamides, is effective in urinary and respiratory infections. Antifungal. Antifungals combat illness caused by fungus such as candida. Fungus-caused infection requires long- term treatment. Drugs such as griseofulvin are often taken for six months. Most fungal infection occurs on the skin or the mucous membrane. Antiviral. Very little is known about treating viral infections (the common cold is an example). A virus is thought to be the smallest infectious agent with the ability to replicate (reproduce) itself. Moreover, it seems able to mutate, or change, with great rapidity. The few drugs that are effective against viral infections interfere with the formation of new, normal cells and are therefore used with extreme caution. Other microbial drugs have little effect on a virus and are given only to treat bacterial infections that accompany or result from the primary viral infection. Resistance and Side Effects An antibiotic acts by limiting or stopping (and therefore killing) the growth of a specific microorganism. It probably accomplishes this by interfering with the wall of the bacteria cell at which it is targeted while at the same time having little effect on the body’s normal cells.