Full Schedule ILANIT 20th-23rd of February 2017 ILANIT / FISEB Federation of all the Israel Societies for Experimental Biology (FISEB) איגוד האגודות הישראליות לביולוגיה ניסויית )אילנית( ILANIT/FISEB is a federation of 31 Israeli societies of experimental biology. ILANIT’s conference is held every three years in Eilat, with attendance by researchers and students. This conference, held in February 2017, is the culmination of the most exciting research performed in Israel in many disciplines. Board President Treasurer Secretary Prof. Karen B. Avraham Prof. Yaron Shav-Tal Prof. Eitan Yefenof (TEL AVIV UNIVERSITY) (BIU) (HUJI) Scientific Organizing Committee Conference President Conference Vice Conference Deputy Conference Vice Orna Amster-Choder President President President (HUJI) Maya Schuldiner (WIS) Angel Porgador (BGU) Eli Pikarsky (HUJI) 2 Last updated 15.02.2017 Scientific Advisory Committee Molecular and Structural Biology and Biochemistry Orna Elroy-Stein, Tel Aviv University (Chair) Ora Furman, Hebrew University of Jerusalem Shula Michaeli, Bar Ilan University Neurobiology and Endocrinology Yuval Dor, Hebrew University of Jerusalem (Chair) Yadin Dudai, Weizmann Institute of Science Assaf Rudich, Ben Gurion University of the Negev Genetics, Genomics, Epigenetics, Bioinformatics and Systems Biology Tzachi Pilpel, Weizmann Institute of Science (Chair) Ohad Birk, Ben Gurion University of the Negev Howard Cedar, Hebrew University of Jerusalem Yael Mandel, Technion – Israel Institute of Technology Medicine, Immunology and Cancer Roni Apte, Ben Gurion University of the Negev (Chair) Neta Erez, Tel Aviv University Yair Reisner, Weizmann Institute of Science Cellular and Developmental Biology Chaya Kalcheim, Hebrew University of Jerusalem (Chair) Chaim Cohen, Bar Ilan University Benny Dekel, Sheba Medical Center and Tel Aviv University Microbiology and Plant Biology Rakefet Schwartz, Bar Ilan University (Chair) Avi Levy, Weizmann Institute of Science Dana Wolf, Hadassah Medical Center BioMed – the Journey of a New Drug from Bench to Bedside Ronit Bendori, Evergreen Venture Partners, Tel Aviv (Chair) Shirley Kutner, Independent senior strategic consultant for biotech, Madrid, Spain Angel Porgador, Ben Gurion University of the Negev Conference Secretariat Ortra Ltd. 1 Nirim Street, P.O. Box 9352, 61092 Tel Aviv, Israel Tel: +972-3-6384444 Fax: +972-3-6384455 Email: [email protected] Conference Web Site: https://www.fiseb.org/ Ortra Web Site: www.ortra.com 3 Last updated 15.02.2017 SOCIETIES Israel Society for Biochemistry and Molecular Biology (ISBMB) האגודה הישראלית לביוכימיה וביולוגיה מולקולרית Israeli Society for Bioinformatics and Computational Biology (ISBCB) אגודה ישראלית לביואינפורמטיקה וביולוגיה חישובית Israel Society for Skeletal Biology and Medicine האגודה הישראלית לביולוגיה ולרפואה של השלד Israel Society for Cancer Research (ISCR) אגודה הישראלית לחקר הסרטן Israel Society for Cell Biology (ISCB) אגודה ישראלית לביולוגיה של התא Israel Society for Clinical Laboratory Sciences (ILMAR) איגוד ישראלי למדעי המעבדה הרפואית Israeli Forum for Cytoskeleton and Motility (IFCM) הפורום הישראלי לשלד ותנועת התא The Israeli Society for Developmental Biology (IsSDB) אגודה ישראלית לביולוגיה התפתחותית Israel Endocrine Society (IES) אגודה ישראלית לאנדוקרינולוגיה The Israeli Society of Gene & Cell Therapy (ISGCT) האגודה הישראלית לתרפיה גנטית ותאית Genetic Society of Israel (GSI) האגודה הישראלית לגנטיקה Israel Society of Heart Research (ISHR) אגודה ישראלית לחקר הלב Israel Immunological Society (IIS) אגודה ישראלית לאימונולוגיה Israeli Society for Mass Spectrometry Israel Society of Medical Genetics אגודה ישראלית לגנטיקה רפואית Israel Society of Microbiology (ISM) אגודה ישראלית למיקרוביולוגיה 4 Last updated 15.02.2017 Israel Society for Microscopy האגודה הישראלית למיקרוסקופיה The Israeli Society for Neuroscience עמותה ישראלית למדעי המוח Israel Society for Oxygen and Free Radicals Research האגודה הישראלית לחקר חמצן ורדיקלים חופשיים Israel Society for Parasitology and Protozoology האגודה הישראלית לפרזיטולוגיה, פרוטוזואולוגיה ומחלות טרופיות Israeli Society for Plant Sciences האגודה ישראלית למדעי הצמח Israel Stem Cell Society (ISCS) אגודה ישראלית לתאי גזע Zoological Society of Israel העמותה לזואולוגיה בישראל 5 Last updated 15.02.2017 MONDAY, FEBRUARY 20, 2017 10:45-15:30 Registration and Refreshments - Dan hotel 15:30-16:00 Opening Ceremony -Herods hotel – Pavilion 16:00-17:00 PL1: PLENARY LECTURE: Regulation of microRNA Herods hotel - Pavilion Narry Kim is a Professor at Seoul National University and a founding director of RNA Research Center at Institute for Basic Science. Kim received her Ph.D. in 1998 from Oxford University on virology, and studied mRNA surveillance as postdoc at the University of Pennsylvania. Her group at SNU has been investigating how microRNAs are made and regulated, and what RNAs and RNA-binding proteins do to control cell fates. Kim received L’Oreal-UNESCO Women in Science (2008) and the Ho-Am Prize in Medicine (2009), and was elected as Foreign Associates of National Academy of Science and of European Molecular Biology Organization. Sponsored by: I-CORE Gene Regulation in Human Complex Disease 17:30-18:30 PL2: PLENARY LECTURE: Being at the Base of the Food Chain May Not Be So Bad After All Herods hotel - Pavilion Prof. Ian T. Baldwin received an AB from Dartmouth College in 1981, his PhD from Cornell University in 1989, rose through the academic ranks at the State University of New York at Buffalo and in 1996 became the founding director of the Max Planck Institute for Chemical Ecology in Jena, Germany, where he heads the Department of Molecular Ecology. He is a member of the US National Academy of Sciences, European Molecular Biology Organization (EMBO), Nationale Akademie der Wissenschaften Leopoldina, Berlin Brandenburgische Akademie der Wissenschaften, Wissenschaftskolleg Berlin, and has published 430 peer-reviewed papers and one book on the Induced defenses of plants. Sponsored by: I-CORE Plant Adaptation to Changing Environment 19:00-23:00 Opening Reception Dinner - Dan hotel Pool Area 6 Last updated 15.02.2017 TUESDAY, FEBRUARY 21, 2017 07:30-08:30 EBT1: Early bird session of Eldan Electronic Instruments Co.Ltd., Herods hotel - Kings hall A Session participants will be enrolled in a lottery having the chance to win a tablet. 08:30 CRISPR Guide RNA Libraries for Functional Genomics Screening: Do You Know What’s in Your Library? Dr. Carsten Carstens Agilent Technologies, Eldan Electronic Instruments Co.Ltd. Screening of CRISPR libraries, either as a knock-out or as a CRISPR A/I approach, has become a very powerful tool for functional genomics approaches to gene function discovery. The quality of the library screen is strongly dependent on the quality of the input library. Based on Agilent’s capability to synthesize up to 2.44 x 105 high quality defined DNA oligomers of 230 nt in length in a single reaction, we have developed novel chemistries, and novel, overlap-based cloning method and workflows necessary for generating high quality, low-bias plasmid libraries. The session will present the procedures and tools required to generate highest quality plasmid libraries from complex oligomer pools. 08:00 Integrated Tools for Sensitive NGS Analysis of ccfDNA Katja Schreiter Ph.D., Market Development Manager BRC & NGS Commercial Partners EMEA QIAGEN, Eldan Electronic Instruments Co.Ltd. Next generation sequencing analysis of free circulating DNA from plasma has quickly been adopted for cancer testing as well as for noninvasive prenatal testing (NIPT). For cancer patients, this method enables the noninvasive diagnosis of actionable mutants to select a personalized anti-tumor therapy and could be used to monitor molecular changes upon cancer treatment or during tumor progression. The concentration of free circulating DNA in liquid biopsies usually is very low, which makes it very important to apply optimized protocols for cfDNA extraction as well as NGS DNA library construction to successfully establish robust test systems. In this scientific talk, we will introduce new technical solutions for Ion Torrent as well as Illumina sequencing platforms that combine optimized cfDNA isolation, highly advanced library construction, unbiased library amplification and integrated data analysis to sensitively and reliably analyze cfDNA samples. 7 Last updated 15.02.2017 TUESDAY, FEBRUARY 21, 2017 07:30-08:30 EBT2: Early Bird session of Zotal Herods hotel - Kings hall B Session participants will be enrolled in a lottery having the chance to win a tablet. 07:30 RNA-Seq as an Efficient Tool for Gene Expression Profiling QuantSeq: High Multiplexing, Sensitivity, and Reproducibility with Lowest Costs and Efforts Birgit Steinmetz Product Manager at Lexogen-Zotal With the discontinuation of microarray systems and the rapid development of NGS technologies, and declining sequencing costs, attention is now on RNA-Seq as the method-of- choice for gene expression (GEX) profiling. Lexogen’s QuantSeq 3’ mRNA-Seq system offers a comprehensive and highly affordable solution for whole transcriptome GEX analyses: With a price from USD 19.80 per library prep and sequencing costs from USD 5.00 per sample, easy handling, and an all-in-one express protocol that is suitable for high throughput screening QuantSeq enables exceptionally precise and cost-effective gene expression experiments. Since only 1 fragment per transcript is generated, FPKM calculations are unnecessary, and a recommended read depth of 2-5 million short, single-end