CONTENTS 1. Welcome addresses 2 2. Introduction 3 3. Acknowledgements 10 4. General information 11 5. Scientific program 16 6. Abstracts – oral presentations 27 7. Abstracts – poster sessions 99 8. Participants 419 1 EMBO Workshop Viruses of Microbes 2018 09 – 13 July 2018 | Wrocław, Poland 1. WELCOME ADDRESSES Welcome to the Viruses of Microbes 2018 EMBO Workshop! We are happy to welcome you to Wrocław for the 5th meeting of the Viruses of Microbes series. This series was launched in the year 2010 in Paris, and was continued in Brussels (2012), Zurich (2014), and Liverpool (2016). This year our meeting is co-organized by two partner institutions: the University of Wrocław and the Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences. The conference venue (University of Wrocław, Uniwersytecka 7-10, Building D) is located in the heart of Wrocław, within the old, historic part of the city. This creates an opportunity to experience the over 1000-year history of the city, combined with its current positive energy. The Viruses of Microbes community is constantly growing. More and more researchers are joining it, and they represent more and more countries worldwide. Our goal for this meeting was to create a true global platform for networking and exchanging ideas. We are most happy to welcome representatives of so many countries and continents. To accommodate the diversity and expertise of the scientists and practitioners gathered by VoM2018, the leading theme of this conference is “Biodiversity and Future Application”. With the help of your contribution, this theme was developed into a program covering a wide range of topics with the strongest practical aspect. We are grateful to members of the VoM2018 scientific committee, local co-organizers, and organizers of previous VoM meetings for the help, support, and creativity that they offered to VoM2018. We are also grateful to the International Society for Viruses of Microorganisms (ISVM) and to the European Molecular Biology Organization (EMBO) for the opportunity to organize this meeting, and also for all their help and support. We are sure you will enjoy the EMBO Viruses of Microbes 2018 conference and you will have a great time in beautiful Wrocław! Krystyna Dąbrowska and Zuzanna Drulis-Kawa (On behalf of the VoM2018 organizing and Scientific Committees) 2 2. INTRODUCTION The central theme of this EMBO Workshop is Viruses of Microbes V: “Biodiversity and future applications” of viruses infecting microbes (algae, archaea, bacteria, fungi, protozoa and viruses). Viruses have always been a key element of microbial diversity and evolution, as well as a tool for molecular biologists to learn more about how the host cell functions. This information has also been put to productive use more recently to control infections and fouling in many areas of our modern life. The conference talks are grouped into sessions covering key areas of ecology, host-virus dynamics, biotechnological, medical aspects, and structural biology. A main objective of this EMBO Workshop is to stimulate new understandings of the role that viruses of microbes play in ecosystems and in the sustainable development of human technologies. 3 ORGANIZERS Krystyna Dąbrowska Zuzanna Drulis-Kawa Institute of Immunology and University of Wrocław, Experimental Therapy PAS, Wrocław, Poland Wrocław, Poland CO-ORGANIZERS Andrzej Górski Grzegorz Węgrzyn Małgorzata Łobocka Institute of Immunology and University of Gdansk, SGGW and IBB PAS, Experimental Therapy PAS, Gdansk, Poland Warsaw, Poland Wrocław, Poland Marcin Łoś Jakub Barylski University of Gdansk, Adam Mickiewicz University, Gdansk, Poland Poznan, Poland 4 SCIENTIFIC COMMITTEE 1. Zuzanna Drulis-Kawa University of Wrocław, Wrocław Poland Institute of Immunology and Experimental Therapy 2. Krystyna Dąbrowska PAS, Wrocław, Poland 3. Rob Lavigne KU Leuven, Leuven, Belgium 4. Tessa Quax University of Freiburg, Freiburg, Germany 5. Laurent Debarbieux Institut Pasteur, Paris, France Winogradsky Institute of Microbiology, RAS, 6. Andrey Letarov Moscow, Russia 7. Ye Xiang Tsinghua University, Beijing, China 8. Peter Fineran University of Otago, Dunedin, New Zeland 9. Alejandro Reyes University of Los Andes, Bogota, Colombia 10. Ramy Aziz Cairo University, Cairo, Egypt 11. David D. Dunigan Nebraska Center for Virology, Lincoln, NE, USA 12. Joana Azeredo University of Minho, Braga, Portugal 13. Mart Krupovic Institut Pasteur, Paris, France 5 INVITED SPEAKERS Matthew Sullivan Stan Brouns Petr Leiman Ohio State University, Delft University of University of Texas Columbus, OH, USA Technology, Delft, Medical Branch, Netherlands Galveston, TX, USA Ye Xiang Valérie de Crécy-Lagard Minna Poranen Tsinghua University, University of Florida, University of Helsinki, Beijing, China Gainesville, FL, USA Helsinki, Finland Rob Lavigne Xu Peng Peter Fineran KU Leuven, University of Copenhagen, University of Otago, Leuven, Belgium Copenhagen, Denmark Dunedin, New Zealand 6 INVITED SPEAKERS Barbara Maciejewska Joana Azeredo Daniel Nelson University of Wrocław, University of Minho, University of Maryland, Wrocław, Poland Braga, Portugal Rockville, MD, USA Venigalla B. Rao Paulina Miernikiewicz Laurent Debarbieux The Catholic University of Institute of Immunology and Institut Pasteur, America, Experimental Therapy PAS, Paris, France Washington, DC, USA Wrocław, Poland Jean-Paul Pirnay Andrzej Górski Elizabeth Kutter Queen Astrid Military Institute of Immunology and Evergreen State College, Hospital, Brussels, Belgium Experimental Therapy PAS, Olympia, WA, USA Wrocław, Poland 7 INVITED SPEAKERS Harald Brüssow Jerome Gabard Alejandro Reyes Nestlé Research Center, Pherecydes Pharma, University of Los Andes, Lausanne, Switzerland Romainville, France Bogota, Colombia Andrew M. Kropinski Daohong Jiang Keizo Nagasaki University of Guelph, Huazhong Agricultural Kochi University, Guleph, ON, Canada University, Kochi, Japan Wuhan, China David Prangishvili Andrey Letarov Matthias Fischer Institut Pasteur, Winogradsky Institute of Max Planck Institute for Paris, France Microbiology RAS, Medical Research, Moscow, Russia Heidelberg, Germany 8 INVITED SPEAKERS Ruth-Anne Sandaa Martin J. Loessner Nina V. Tikunova University of Bergen, ETH Zurich, Institute of Chemical Biology Bergen, Norway Zurich, Switzerland and Fundamental Medicine RAS, Novosibirsk, Russia Ramy K. Aziz James Rodney Brister Mzia Kutateladze Cairo University, National Institutes of Health, G. Eliava Institute of Cairo, Egypt Bethesda, MD, USA Bacteriophages, Microbiology and Virology, Tbilisi, Georgia 9 3. ACKNOWLEDGMENTS 10 4. GENERAL INFORMATION Theme of Conference More than a century of research on viruses of microbes led to major discoveries in biology. Scientific interest in viruses of microbes is constantly growing, opening the way to new findings and applications. This conference series is intended to bring together researchers involved in all fields related to viruses of microbes and provide an opportunity to exchange and inspire ideas. The central theme of the meeting is ‘Biodiversity and future applications’ of viruses infecting microbes: algae, archaea, bacteria, fungi, protozoa and viruses. Viruses have always been a key element of microbial diversity and evolution, as well as a tool for molecular biologists to learn more about how the host cell functions. This information has also been put to productive use in recent times to control infections and fouling in many areas of our modern life. The conference talks are grouped into sessions covering key areas of ecology, host-virus dynamics, biotechnology, medical aspects, and structural biology. One of the main objectives of the meeting is to stimulate new understanding of the role that viruses of microbes play in ecosystems and in the sustainable development of human technologies. This conference will also promote the actions of the International Society for Viruses of Microorganisms (ISVM) and functions as the official bi-annual meeting of this society. Wi-Fi A Wi-Fi connection will be available in the auditorium and in the hall of building. Network: emboworkshop | Password: 0913072018 Certificates of Attendance Certificates for participants will be send automatically by email. Photography and Filming The EMBO may carry out filming and photography throughout the conference. The videos and images will be used to promote the conferences and other activities of EMBO. They may be used online, in EMBO publications, or for other PR and marketing purposes. Only recording and photography of presentations are allowed with prior permission from the authors. 11 Social Media Find us on Facebook: https://www.facebook.com/events/558390551168563/ Program changes While every effort will be made to keep program changes to a minimum, any changes will be advised at the registration desk. Please note that the website is mobile optimized and any changes will appear as soon as possible. http://meetings.embo.org/event/18-virus-microbe Posters The poster should be printed in portrait orientation at a size no larger than B1 (70 cm (W) x 100 cm (H)). Poster presentation will take place in strictly defined locations. The order of the presentation will be consistent with the submission ID (please check it on your EMBO profile or find your abstract in this book ). City Tour During the conference, a facultative one-hour city tour will be organized during the lunch break on 11 th of July (from 14:00 to 15:00). Please feel free to participate and sign up at the reception during the