The Francis Crick Memorial Conference Consciousness in Human and Non‐Human Animals Wolfson Hall, Churchill College Cambridge, United Kingdom "It is essenƟal to understand our Crick Memorial Conference: num Sponsor of the Francis Ɵ brains in some detail if we are to assess correctly our place in this Proud Pla Proud vast and compli- cated universe we see all around us." - Francis Crick All Bordering Photos Courtesy Google Images The Francis Crick Memorial Conference Francis Crick (1916‐2004) Thank you to all of our sponsors for your support in making the Francis Crick Memorial Conference a success and for helping us to fuel this unprecedented discussion on data‐driven perspectives on the neural correlates of consciousness. Sponsored by: The Francis Crick Memorial Conference The Francis Crick Memorial Conference Schedule of Events Schedule of Events 7:45 Check‐in / Complimentary 13:00 Complimentary Lunch Breakfast 14:00 Diana Reiss, Ph.D. Mirror Self‐recognition: A Case of 8:30 Christof Koch, Ph.D. Studying the Murine Mind Hunter College and Cognitive Convergence in Humans Allen Institute for Brain Science, City University of New York and other Animals Caltech 14:30 Franz X. Vollenweider, MD Neuronal Correlates of Psychedelic 9:00 Invited Lecture: Consciousness: A Pharmacological University of Zü rich School of Drug‐Induced Imagery in Humans Baltazar Gomez‐Mancilla, Perspective Medicine, Heffter Research Centre MD Ph.D. Novartis Institute of 15:00 Naotsugu Tsuchiya, Ph.D. Visual Consciousness Tracked with Biomedical Research RIKEN, ATR, Japan, Caltech, Direct Intracranial Recording from 9:30 Ryan Remedios, Ph.D.* The Claustrum and the Orchestra of Monash University Early Visual Cortices in Humans CalTech Cognitive Control Nikos K. Logothetis, Ph.D. 15:30 Coffee Break Christoph Kayser, Ph.D. Special Unveiling Ceremony Located in the Foyer MaxPlanck Institute for Biological in Memory of Francis Crick Artist: Odile Crick Cybernetics 16:00 Steven Laureys, MD, Ph.D. Identifying the Brain’s Awareness 10:00 Coffee Break Special Unveiling Ceremony Located in the Foyer Cyclotron Research Center, System: Lessons from Coma and in Memory of Francis Crick Artist: John Houser University of Liège, FNRS Related States 10:30 Bruno van Swinderen, Ph.D. Neural Correlates of 16:30 Melanie Boly, MD, Ph.D. Cerebral Connectivity in Disorders of The University of Queensland Unconsciousness in Drosophila University of Liège, Consciousness University of Wisconsin 11:00 David B. Edelman, Ph.D. Through the Eyes of an Octopus: An The Neurosciences Institute, Invertebrate Model for Consciousness 17:00 Philip Low, Ph.D.* Towards Establishing Neural The Scripps Research Institute Studies NeuroVigil, Stanford, MIT Correlates of Intended Movements & and Speech 11:30 Irene Pepperberg, Ph.D. Human‐like Consciousness in Stephen W. Hawking, D.Phil. Brandeis University, Harvard Non‐Humans: Evidence from Grey University of Cambridge University, The Alex Foundation Parrots 17:30 Panel The Cambridge Declaration on 12:00 Invited Lecture: Are Commonalities in Brain Consciousness in Human and Harvey Karten, MD Microarchitecture and Behavior in Non‐Human Animals The University of California, San Diego Humans and Birds a Coincidence? 18:00 Philip Low, Ph.D. Closing Remarks 12:30 Keynote Speaker: Emotional Feelings of Other Ani‐ NeuroVigil, Stanford, MIT Jaak Panksepp, Ph.D. mals: Are Their Affects Homologous Washington State University to Our Own? * Presenting Author The Francis Crick Memorial Conference The Francis Crick Memorial Conference Dr. Christof Koch joined the Allen Institute as Chief Scientiic Oficer in Dr. Gomez-Mancilla obtained a Medicine Degree at the National Autono- 2011. For the past 25 years, Koch has served on the faculty at the Cali- mous University of State of Mexico in Toluca, Mexico. Then he moved to fornia Institute of Technology (Caltech), from his initial appointment Canada, where he obtained a Doctoral Degree in Experimental Neurology, as Assistant Professor, Division of Biology and Division of Engineering developing a Primate Model of l-dopa induced dyskinesias, at the Faculty and Applied Sciences in 1986, to his most recent position as Lois and of Medicine Laval University. He obtained “The Gorge Copty Award on Victor Troendle Professor of Cognitive & Behavioral Biology. Previous- Neurological Sciences” for his contributions in the understanding of Basal ly, he spent four years as a postdoctoral fellow in the Artiicial Intelli- Ganglia circuit in Parkinson’s disease. He continued his Clinical Neurologi- gence Laboratory and the Brain and Cognitive Sciences Department at cal training at l'Hôpital de l'Enfant-Jésus in Quebec under Prof. Paul Be- the Massachusetts Institute of Technology. He received his baccalaure- dard’s supervision. He was awarded a Fellowship from Medical Research ate from the Lycée Descartes in Rabat, Morocco, his M.S. in physics Council of Canada to perform Post-Doctoral studies in Clinical Pharmacol- from the University of Tü bingen in Germany and his Ph.D. from the ogy and Drug Metabolism leading him to obtain the ‘Psychopharmacology Christof Koch, Ph.D. Max-Planck-Institut fü r Biologische Kybernetik, Tü bingen. Award’ by the University of Toronto for his contributions to the under- Chief Scientiic Baltazar Gomez‐ Koch has published extensively, and his writings and interests inte- Mancilla MD PhD standing of psychotropic drug metabolism in the CNS. Dr. Gomez- Oficer at the Allen grate theoretical, computational and experimental neuroscience. Executive Director Mancilla took on the role of Director of Clinical Research at The Upjohn Institute for Brain Stemming in part from a long-standing collaboration with the late of Neuroscience Company in Kalamazoo, Michigan, leading the clinical strategy for the Science, Seattle. Nobel Laureate Francis Crick, Koch authored the book “The Quest for Translational development of two successful new drug applications to the FDA, includ- Lois and Victor Consciousness: A Neurobiological Approach.” He has also authored the Medicine ing Pramipexole for the treatment of Parkinson’s disease, and Almotrip- Troendle Professor technical books “Biophysics of Computation: Information Processing tan for the treatment of Migraine. Novartis Institute of of Cognitive and in Single Neurons” and “Methods in Neuronal Modeling: From Ions to Dr. Gomez-Mancilla currently holds the position of Executive Director of BioMedical Behavioral Biology Networks,” and served as editor for several books on neural modeling Translational Medicine in Neuroscience at the Novartis Institute of Bio- Research at California Insti‐ and information processing. Koch’s research addresses scientiic ques- medical Research in Basel, Switzerland. In 2008 he received the Novartis tute of Technology, tions using a widely multidisciplinary approach. NSO Navigator Award, the Novartis Translational Science Award in 2009, Pasadena, CA His research interests include elucidating the biophysical mechanisms and the ‘VIVA Award” as a Leading Scientist in 2010 for his contributions underlying neural computation, understanding the mechanisms and to the development of new therapeutic strategies in Parkinson’s disease purpose of visual attention, and uncovering the neural basis of con- and developmental pervasive disorders, respectively. sciousness and the subjective mind. Koch maintains a part-time ap- Dr Gomez-Mancilla holds a professorship at the Max Planck Institute of pointment and laboratory at Caltech. Neurobiology, University of Tü bingen. Throughout his career, he has iden- Text: Courtesy of Allen Institute for Brain Science tiied several new drugs and alternative indications in neurological and psychiatric disorders. He has iled 15 patent applications and has au- thored more than 50 peer-reviewed scientiic articles and book chapters. Studying the Murine Mind Consciousness: A Pharmacological Perspective Christof Koch, Ph.D. Baltazar Gomez-Mancilla, MD Ph.D. Consciousness has been traditionally deined by the ability of an individu- Mice are a very promising model system for studying the neuronal al to effectively communicate with his/her surrounding world. The classi- cal medical classiication of state of consciousness in a patient (i.e. Glas- correlates of consciousness. Their brain structure is similar to that of gow scale) is derived from an observational study of the individual’s the human, they display complex behavior, and their underlying neu- physical reactions to external stimuli, but is not able to capture any resid- ronal responses can be measured using optics and silicon probes at ual cognitive brain activity. cellular level of resolution. In contrast to the blunt and edentate tools The developments of new technologies that permit to capture neuronal available to probe the human brain, the recent emergence of optoge- activity have made a revolution in terms of our understanding of the dei- netics allows scientists to delicately, transiently, and reversibly control nition of consciousness. Functional Magnetic Resonance imaging has allowed the identiication of brain circuits involved in complex mental deined events in deined cell types at deined times in mice. This al- interactions like awareness and cognition. Cognition is a key brain pro- lows us to move from correlation to causation, from observing that cess that mediates our interaction with the external environment. It de- this circuit is activated whenever the subject is perceiving something ines how do we perceive the world and react in consequence. Cognition to inferring