The Pain Source Makes Learning About Pain, Painless http://thepainsource.com Nerve Injury Classifications – Seddon’s and Sunderland’s Author : admin By Chris Faubel, MD -- Understanding nerve injury classification is essential for prognostic value clinically. Some basic anatomy, along with the two classification systems, and their corresponding EMG findings need to be learned and remembered. Two classification systems exist (and are frequently tested in various exams): 1. Seddon's classification (neuropraxia, axonotmesis, neurotmesis) 2. Sunderland's classification (types 1-5) To understand the systems, you must first review some basic nerve anatomy. There are three connective tissue layers in the CNS and PNS. 1. epineurium 2. perineurium 3. endoneurium Individual nerve fibers (single axons) are covered with varying amounts of myelin and then covered by endoneurium. These individually wrapped nerve fibers are then grouped into bundles of fibers called fascicles, which are covered by perineurium. Finally, groups of fascicles are bundled together to form the peripheral nerve (such as the median nerve), which is covered by epineurium. Seddon's classification: Neuropraxia 1 / 3 The Pain Source Makes Learning About Pain, Painless http://thepainsource.com Physical Medicine & Rehabilitation Board Review - Sara Cuccurullo, MD refers to local myelin injury with the axon still intact and functional motor > sensory fibers affected considered a temporary paralysis of the nerve fiber least severe injury usually from crush injury or ischemia Electrodiagnostic findings: (click the image to the right) note: normal CMAP amplitude distal to the lesion at day 10 is a "good" sign --> diagnosis of mild neuropraxia instead of axonotmesis or neurotmesis Recovery: hours to months (avg 6-8 weeks) Axonotmesis the axon and myelin is disrupted here, but the neuronal connective tissue remains intact (endo-, peri-, epineurium) more severe crush injury than that which causes neuropraxia Wallerian degeneration occurs because of loss of axoplasmic flow Electrodiagnostic findings: (click the image to the right) absent nerve conduction distal to the lesion decreased amplitude and recruitment immediately spontaneous potentials (positive sharp waves & fibrillations) in 2-3 weeks Regeneration (if neuronal coverings are intact) occurs at about 1.5-3mm/day Recovery: weeks to months Neurotmesis most severe form not only the axon, but also injury to the myelin, endoneurium, perineurium, and in the most severe case, the epineurium Electrodiagnostic findings: (click the image to the right) same as with axonotmesis note: clinically, neurotmesis and axonotmesis present the same (motor, sensory, autonomic paralysis, and muscle atrophy) surgical repair is typically needed Recovery: incomplete; imperfect Sunderland's classification: consists of 5 degrees of injury (further stratifying the extent of endo/peri/epineurium involvement) 1st degree 2 / 3 The Pain Source Makes Learning About Pain, Painless http://thepainsource.com Physical Medicine & Rehabilitation Board Review - Sara Cuccurullo, MD essentially the same as neuropraxia 2nd degree same as axonotmesis 3rd degree axonotmesis, plus endoneurium disruptions 4th degree axonotmesis, plus endo- and perineurium disruptions 5th degree same as neurotmesis (complete transection) [caption id="attachment_344" align="alignleft" width="550" caption="Medscape.com"] [/caption] 3 / 3 Powered by TCPDF (www.tcpdf.org).