20152015 18th Annual Upstate New York Immunology Conference Major Corporate Sponsors: BD Biosciences BioLegend, Inc. Taconic Bioscience Keynote Speakers: Supported by Yasmine Belkaid, Ph.D. NIH/NIAID Kristin A. Hogquist, Ph.D. Grant Funding Workshop Presentation by: Yasmine Belkaid, Ph.D. Jacob Schumacher, AAI AAI Young Investigator Awards eBioscience/affymetrix Trainee Travel Awards Welcome to The Sagamore Resort and Conference Center Bolton Landing, NY October 25-28, 2015 2. UPSTATE NEW YORK IMM UNOLOGY CONFERENCE ( NYIC) We’ve come a long way from Garnet Hill! This meeting started in 1997 as a small retreat to facilitate interactions among young scientists, institutions, and renowned experts in the field of Immunology. In just a few short years, the number of attendees grew and a larger venue was needed to meet the future needs of the Conference. We are happy to announce the American Association of Immu- nologists (AAI) is once again providing 10 Young Investigator Awards. eBioscience is also proving 10 Trainee Travel Awards. All award winners will give Oral Poster Presentations. There will also be two Workshops. Keynote speakers are Dr. Yasmine Belkaid (NIH/NIAID) and Dr. Kristin A. Hogquist (University of Minnesota). As part of our leisure activities, there will be a cruise on Lake George, as well as a recreational night including miniature golf, Wii, X-box, whiffle ball, and movies! Mr. Brown’s Pub will be open Tuesday night for informal discussions. Trainees will also have an opportunity to win an iPad during one of two drawings. You must be present at the drawing to win! While all these elements lend to the atmosphere, one simple principle goal of this Conference re- mains. To provide an opportunity for young and senior scientists to gather in a setting that is diverse enough to meet the needs of all attendees while remaining small enough to allow for personal interac- tions. While always challenging, it is the goal of the NYIC Scientific Advisory Board and the NYIC Confer- ence Organizers to give graduate students and postdoctoral fellows the opportunity to present their re- search and engage in conversations that will stimulate further discussions, collaborations, and interest in pursuing a new or different way of looking at their research. We hope you share our enthusiasm and enjoy your time with us! THE SAGAMORE RESORT The Sagamore Resort and Conference Cen- ter celebrated it’s 125 year anniversary in 2008. Since that time, the resort has gone through some remarkable renovations. If this is your first visit to the Resort, take some time to enjoy the beauty that surrounds you. There are many breath-taking views to be seen. The staff are friendly, courteous, and hard-working. If you require any information or have a special need, please see either Dawn Bellville, Administrative Coordinator for NYIC, or any of the Resort person- nel. Many thanks to Lori Rehm (Director of Sales), Eric Rottingen (National Sales Manager), Derrick Hammond (Conference Services Manager), Don Vilmar (Banquet Manager), Jerid McKinney (Banquet Captain), Joel Clark (Function Set-up Manager) and his amazing crew, CMI Communications-Audio/Visual Manager crew, Glen and Al, along with all of the associates who attend to our many needs. Thank you! 3. Table of Contents Conference and Venue ............................................................................... 3 Schedule of Events .................................................................................... 6 Platinum Corporate Sponsors BD Biosciences ..................................................................................... 16 BioLegend, Inc. .................................................................................... 18 Taconic Bioscience ................................................................................ 20 Silver Plus Corporate Sponsors .................................................................... 22 eBioscience/affymetrix .......................................................................... 23 EMD Millipore ....................................................................................... 24 Krackeler Scientific ................................................................................ 25 Silver Corporate Sponsors ........................................................................... 26 Dartmouth ........................................................................................... 27 Lonza .................................................................................................. 28 Bronze Corporate Sponsors ................................................................... 29 American Association of Immunologists ....................................................... 30 NYIC Scientific Advisory Board .................................................................... 31 Institutional Financial Supporters ................................................................ 32 Grant Support ............................................................................................ 33 Keynote Speaker Kristin A. Hogquist, Ph.D. ...................................................................... 34 Symposium I Regulatory T-cells ................................................................................. 35 Symposium II T-cell Biology ........................................................................................ 38 4. Poster Talks Session A: Adaptive Immunity ............................................................... 41 Session B: Innate Immunity .................................................................. 47 Corporate Presentation: BioLegend, Inc. ..................................................... 53 Workshop I - Dr. Belkaid “TBA” .................................................................................................. 54 Poster Talks Session C: Inflammation ....................................................................... 55 Session D: Tumor Cancer ...................................................................... 61 Corporate Presentation: BD Biosciences ...................................................... 67 Symposium III Inflammation ....................................................................................... 68 Symposium IV Immune Regulation .............................................................................. 72 Corporate Presentation: Taconic Biosciences ................................................ 76 Workshop II - AAI “The Urgent Importance of Advocating for Biomedical Research” ............. 77 Symposium V Antigen Presenting Cell Biology ............................................................. 78 Keynote Speaker Yasmine Belkaid, Ph.D. ......................................................................... 82 Poster Listing ............................................................................................ 83 Poster Abstracts ........................................................................................ 84 Attendee Contact Information ..................................................................... 130 Author Index ............................................................................................. 134 5. Upstate New York Immunology Conference Schedule of Events Sunday, October 25th 3:00-5:00 p.m. Hotel Check-in (Main Hotel Lobby) 3:00-5:00 p.m. Conference Registration (Conference Center Lobby) 5:00-6:00 p.m. Free Time 6:00-6:30 p.m. Dinner (Bellvue) 6:30 p.m. Welcome and Introductions Keynote Presentation Sponsored by BD Biosciences Introduction: Dr. Dennis W. Metzger Kristin A. Hogquist, Ph.D. Professor Department of Laboratory Medicine & Pathology University of Minnesota “T Cell Adolescence” 7:45 p.m. American Association of Immunologists Young Investigator Awards and eBioscience Travel Awards (Award Presentations & Photos) Immediately Following Awards Presentation—Meet and Greet Activities (Recreation Center) 6. Monday, October 26th 7:00-8:15 a.m. Breakfast at Leisure (Use Voucher Dated 10/26/15) (La Bella Vita) 8:25-8:30 a.m. Morning Announcements (Nirvana) 8:30-9:30 a.m. Symposium I: Regulatory T-Cells (Nirvana) Chair: Dr. Yasmine Belkaid 8:30-9:00 Tamer B. Chabanet, Ph.D. (Dartmouth Medical College) “Elucidating Oncogene-driven Regulatory T-Cell Responses during Melanoma Tumorigenesis” 9:00-9:30 Elizabeth A. Wohlfert, Ph.D. (University at Buffalo) “Dynamics of Tregs during Infection with T. gondii” 9:30-10:30 a.m. Symposium II: T-Cell Biology (Nirvana) Chair: Dr. Kristin Hogquist 9:30-10:00 Yina H. Huang, Ph.D. (Dartmouth Medical College) “Visualizing and Manipulating T-Cell Responses in vivo” 10:00-10:30 Scott H. Olejniczak, Ph.D. (Roswell Park Cancer Institute) “T-Cell Activation Improves MicroRNA Function” 10:30-10:50 a.m. Break (Conference Center Foyer) 10:50-12:05 p.m. Poster Talks: Session A—Adaptive Immunity (Albenia) Chairs: Dr. Drake and Dr. Wohlfert 10:50-11:05 Lisbeth A. Boule (University of Rochester) “Activation of the Aryl Hydrocarbon Receptor by Categorically Different Ligands Alters the Immune Response to Primary Influenza A Virus Infection” #4 7. 11:05-11:20 Kevin Kenderes (SUNY Upstate Medical University) “IgM Memory B-cells Differentiate via Multiple Pathways Following Challenge Infection” #13 11:20-11:35 Rebecca Crepeau (Dartmouth College) “miR-155 Plays a Critical Role in the Establishment and Maintenance of Latency in Murine Gammaherpesvirus Infection” #9 11:35-11:50 Jocelyn Wang (Cornel University) “Fetal Hematopoietic Stem Cells Give Rise to a Unique