Babraham Institute Capturing the Economic Impact of the Babraham Institute January 2013 Alacrita LLP Alacrita LLC The London BioScience Innovation Centre One Broadway, 14th Floor 2 Royal College Street Kendall Square London NW1 0NH Cambridge MA 02142 www.alacritaconsulting.com alacrita Copyright © 2013 Alacrita LLP Babraham Institute alacrita Copyright © 2013 Alacrita LLP Babraham Institute Table of Contents Figures ......................................................................................................................................................... 1 Tables ........................................................................................................................................................... 2 Abbreviations................................................................................................................................................ 3 Chapter 1. Executive summary ....................................................................................................................... 4 Chapter 2. Background, methodology & policy context .................................................................................. 6 2.1 BIS policy objectives & investment ..................................................................................................... 6 2.2 BBSRC policy objectives & investment ................................................................................................ 7 2.3 RCUK policy objectives ....................................................................................................................... 7 2.4 Research Methodology ...................................................................................................................... 9 Chapter 3. Introduction & profile of the Babraham Institute ......................................................................... 13 3.1 Research focus on lifelong wellbeing and healthier ageing .............................................................. 13 3.2 BI Profile ......................................................................................................................................... 13 3.3 BBSRC funding for health and wellbeing research ............................................................................ 14 3.4 Babraham Research Campus: Discovery Biology for Lifelong Heath ................................................. 15 Chapter 4. Research excellence & Impact at the Babraham Institute ............................................................ 16 4. 1 The policy context .......................................................................................................................... 16 4.2 Scientific output & impact ............................................................................................................... 17 4.3 The economic impact of fundamental research ................................................................................ 20 4.4 Babraham research portfolio evolution ........................................................................................... 21 4.5 The economic impact of fundamental research at the Babraham Institute ...................................... 23 Chapter 5. Economic Impact of translational Research................................................................................. 28 5.1 Value Chain Analysis......................................................................................................................... 28 5.2 Translational activities leading to economic impact .......................................................................... 29 5.3 Babraham-driven projects leading to economic impact .................................................................... 30 5.4 Partner-driven projects leading to economic impact......................................................................... 34 5.5 Summary of evidence of value chain ............................................................................................... 35 Chapter 6. Economic impact of the Babraham Research Campus .................................................................. 37 6.1 BBT economic impact created through new products and services ................................................... 37 6.2 Development of the Babraham Bioincubator & BRC ......................................................................... 38 6.3 Economic Impact of the BRC............................................................................................................. 39 6.4 The Babraham Research Campus Ecosystem .................................................................................... 40 6.5 BRC position in the UK economy ...................................................................................................... 43 6.6 Value network analysis ..................................................................................................................... 44 Chapter 7. Pathways to Impact as set out by the Research Councils UK ......................................................... 46 7.1 UK business success through public investment in research ............................................................. 46 7.2 How research is translated into business & commercial impact ........................................................ 46 7.3 Development of human capital ........................................................................................................ 48 7.4. Policy .............................................................................................................................................. 53 7.5 Quality of life, knowledge exchange and public engagement ............................................................ 53 7.6. National facilities............................................................................................................................. 59 Chapter 8. Operating impact........................................................................................................................ 60 8.1 Methodology ................................................................................................................................... 60 8.2 Income analysis ................................................................................................................................ 61 8.3 Expenditure analysis......................................................................................................................... 63 8.4 Direct Impact ................................................................................................................................... 64 8.5 Indirect impact ................................................................................................................................. 64 8.6. Induced impact ............................................................................................................................... 64 8.7 Overall operational impact ............................................................................................................... 65 8.8 Estimated local impact .................................................................................................................... 65 alacrita Copyright © 2013 Alacrita LLP Babraham Institute Conclusions ................................................................................................................................................ 66 Appendices ................................................................................................................................................. 67 Appendix 1. Annual incidence and mortality of most common cancers, UK 2010 ................................... 68 Appendix 2. PI3 Kinase (and related mTOR Kinase) inhibitors in clinical development ............................ 69 Appendix 3. Babraham Group, Consolidated Income 2011/12 ................................................................ 70 Appendix 4. Worldwide Therapeutic Monoclonal Antibody Market ....................................................... 71 Appendix 5. Babraham Research Campus Commercial Tenants 2013 ..................................................... 72 alacrita Copyright © 2013 Alacrita LLP Babraham Institute Page 1 of 76 FIGURES Figure 1 BIS Success Indicators ..................................................................................................................... 6 Figure 2 RCUK Pathways to Impact ................................................................................................................ 8 Figure 3 The components of economic impact .............................................................................................. 11 Figure 4 Profile of research grants 2005-2013 ............................................................................................. 15 Figure 5 Babraham research productivity, a) total original research papers, and b) research papers per PI from 2005-October 2012. ............................................................................................................................ 17 Figure 6 Average Impact Factor of Babraham original research publications 1992-2012 ................................ 18 Figure 7 Babraham quality-adjusted research productivity, a) Total Impact Factor, & b) Total Impact Factor per PI ....................................................................................................................................................... 18