DEPARTMENT OF HEALTH AND HUMAN SERVICES CENTERS FOR DISEASE CONTROL AND PREVENTION Advisory Committee on Immunization Practices (ACIP) Summary Report February 26-27, 2020 Atlanta, Georgia This document has been archived for historical purposes. (3/1/2020) https://www.cdc.gov/vaccines/acip/meetings/downloads/min-archive/min-2020-02-508.pdf Advisory Committee on Immunization Practices (ACIP) Summary Report February 26-27, 2020 Table of Contents Page Agenda 4-5 Acronyms 6-11 Wednesday: February 26, 2020 Welcome and Introductions 12-14 Ebola Vaccine Introduction Review of Ebola Virus Disease and rVSVΔG-ZEBOV-GP Vaccine GRADE 14-49 EtR and Summary of Work Group Considerations and Proposed Policy Options Vote 2019 Novel Coronavirus (2019-nCov) Informational Session 49-55 Influenza Vaccines Introduction Older Adult (65+) Adjuvanted Quadrivalent Influenza Vaccine (aIIV4) ‘ 2019-20 US Influenza Surveillance Update 56-72 2019-20 US Influenza Vaccine Effectiveness Update Safety of Adjuvanted vs. High-Dose Inactivated Influenza Vaccines in Older Adults Summary and Work Group Considerations Thursday: February 27, 2020 Agency Updates Centers for Disease Control and Prevention (CDC) Center for Medicare and Medicaid Services (CMS) Department of Defense (DoD) Department of Veteran’s Affairs (DVA) Food and Drug Administration (FDA) 73-77 Heath Resources and Services Administration (HRSA) Indian Health Services (I HS) National Institutes of Health (NIH) Office of Infectious Disease Policy and HIV/AIDS (OIDP) o National Vaccine Advisory Committee (NVAC) o National Vaccine Program Office (NVPO) Rabies Vaccine Introduction Background on PrEP, Vaccine Safety, and Work Group Considerations 78-96 Rabies Vaccine Schedule & Duration of Immunity (Systematic Review Data) Work Group Next Steps 2 This document has been archived for historical purposes. (3/1/2020) https://www.cdc.gov/vaccines/acip/meetings/downloads/min-archive/min-2020-02-508.pdf Advisory Committee on Immunization Practices (ACIP) Summary Report February 26-27, 2020 Dengue Virus Vaccines Introduction Dengue Vaccine Acceptability in Puerto Rico 96-111 SAGE Perspective on DENGVAXIA® Summary of Work Group Considerations Polio Informational Session Introduction 112-123 Polio and Polio Policy in the United States: The Oral Polio Vaccine to Inactivated Vaccine Switch Global Polio Eradication: Progress and Prospects Hepatitis B Vaccine 123-124 Work Group Updated General Best Practices Introduction 124-126 Update on Recent Postings Vaccine Supply 127 Certification 128 Membership Roster 129-137 3 This document has been archived for historical purposes. (3/1/2020) https://www.cdc.gov/vaccines/acip/meetings/downloads/min-archive/min-2020-02-508.pdf Advisory Committee on Immunization Practices (ACIP) Summary Report February 26-27, 2020 4 This document has been archived for historical purposes. (3/1/2020) https://www.cdc.gov/vaccines/acip/meetings/downloads/min-archive/min-2020-02-508.pdf Advisory Committee on Immunization Practices (ACIP) Summary Report February 26-27, 2020 5 This document has been archived for historical purposes. (3/1/2020) https://www.cdc.gov/vaccines/acip/meetings/downloads/min-archive/min-2020-02-508.pdf Advisory Committee on Immunization Practices (ACIP) Summary Report February 26-27, 2020 Acronyms AAFP American Academy of Family Physicians AAP American Academy of Pediatrics ACCV Advisory Commission on Childhood Vaccines ACHA American College Health Association ACIP Advisory Committee on Immunization Practices ACOG American College of Obstetricians and Gynecologists ACP American College of Physicians ACS American Cancer Society AE Adverse Event AECI Adverse Events of Clinical Interest AESI Adverse Events of Special Interest AFM Acute Flaccid Myelitis AFRO Africa Regional Office AHIP America’s Health Insurance Plans AI/AN American Indian/Alaskan Native aIIV Adjuvanted Inactivated Influenza Vaccine AIM Association of Immunization Managers AIRA American Immunization Registry Association AMA American Medical Association AMGA American Medical Group Association AOA American Osteopathic Association APhA American Pharmacists Association APHL Association of Public Health Laboratories AS American Samoa ASH Assistant Secretary for Health ASPR Assistant Secretary for Preparedness and Response ASTHO Association of State and Territorial Health Officers ATS American Thoracic Society BLA Biologics License Application BSC, DDID Board of Scientific Counselors, Deputy Director for Infectious Diseases BSL-4 Biosafety Level 4 CBER Center for Biologics Evaluation and Research ccIIV Cell Culture-Based Inactivated Influenza Vaccine CDC Centers for Disease Control and Prevention CEA Cost-Effectiveness Analysis CHMP Committee for Medicinal Products for Human Use CICP Countermeasures Injury Compensation Program CISA Clinical Immunization Safety Assessment CLD Chronic Liver Disease CLIA Clinical Laboratory Improvement Amendments CMS Center for Medicare and Medicaid Services CNS Central Nervous System COI Conflict of Interest COPA Communities Organized to Prevent Arboviruses COVID-19 Coronavirus Disease 2019 CSF Cerebrospinal Fluid CSTE Council of State and Territorial Epidemiologists 6 This document has been archived for historical purposes. (3/1/2020) https://www.cdc.gov/vaccines/acip/meetings/downloads/min-archive/min-2020-02-508.pdf Advisory Committee on Immunization Practices (ACIP) Summary Report February 26-27, 2020 cVDPV2 Circulating Vaccine-Derived Poliovirus DC District of Columbia DENV Dengue Virus DFO Designated Federal Official DNA Deoxyribonucleic Acid DoD Department of Defense DRC Democratic Republic of Congo DSMB Data Safety Monitoring Board DSTDP Division of STD Prevention DTaP Diphtheria and Tetanus Toxoid and Pertussis DVA Department of Veterans Affairs DVD Division of Viral Diseases ED Emergency Department EHR Electronic Health Record EIS Epidemic Intelligence Service ELISA Enzyme-Linked Immunosorbent Assay EMA European Medicines Agency EMP Essential Medicine Department EMR Electronic Medical Record EMRO Eastern Mediterranean Region Office EQ-5D-5L EuroQOL-5 Dimensions-5 Levels EQ-VAS EuroQol-Visual Analogue Scale ETC Ebola Treatment Center EtR Evidence to Recommendation EU European Union EUA Emergency Use Authorization EUL Emergency Use Listing EURO Europe Regional Office EV Enteroviruses EVD Ebola Virus Disease FDA Food and Drug Administration FQHC Federally Qualified Health Center FY Fiscal Year GAVI Global Alliance for Vaccines and Immunisation; The Vaccine Alliance GBS Guillain-Barré Syndrome GCC Global Certification Commission GCC (Tom Harkin) Global Communications Center GI Gastrointestinal GID Global Immunization Division GISRS Global Influenza Surveillance and Response System GMC Geometric Mean Concentration GMT Geometric Mean Titers GP Glycoprotein GPEI Global Polio Eradication Initiative GRADE Grading of Recommendation Assessment, Development and Evaluation GSK GlaxoSmithKline HAV Hepatitis A Virus HBIG Hepatitis B Immune Globulin HCoVs Human Coronaviruses 7 This document has been archived for historical purposes. (3/1/2020) https://www.cdc.gov/vaccines/acip/meetings/downloads/min-archive/min-2020-02-508.pdf Advisory Committee on Immunization Practices (ACIP) Summary Report February 26-27, 2020 HCP Healthcare Personnel / Providers HCW Healthcare Workers HDCV Human Diploid Cell Vaccine HD-IIV High-Dose Inactivated Influenza Vaccine HepA Hepatitis A HepB Hepatitis B HHS (Department of) Health and Human Services HI Hemagglutinin Inhibition HIV Human Immunodeficiency Virus HMO Health Maintenance Organization HPV Human Papillomavirus HRQOL Health-Related Quality of Life HRSA Health Resources and Services Administration ICD International Classification of Diseases IDCRP Infectious Disease Clinical Research Program ICU Intensive Care Unit ID Intradermal IDSA Infectious Disease Society of America Ig Immunoglobulin IHB Immunization Healthcare Branch IHD Immunization Healthcare Division (DoD) IHR International Health Regulation IHS Indian Health Service IIS Immunization Information Systems IIV Inactivated Influenza Vaccine ILI Influenza-Like Illness ILINet Influenza-like Illness Surveillance Network IM Intramuscular IPV Inactivated Polio Vaccine ISD Immunization Services Division ISO Immunization Safety Office ISTM International Society for Travel Medicine IVIG Intravenous Immunoglobulin KPSC Kaiser Permanent Southern California LAIV Live Attenuated Influenza Vaccine LRN Laboratory Response Network MASO Management Analysis and Services Office MedDRA Medical Dictionary for Regulatory Activities MERS Middle East Respiratory Syndrome MHS Military Health System MMR Measles, Mumps, and Rubella MMWR Morbidity and Mortality Weekly Report mOPV Monovalent OPV MSM Men Who Have Sex With Men MI Multiple Imputation NACCHO National Association of County and City Health Officials NACI National Advisory Committee on Immunization Canada NAIP National Adult Immunization Plan NAIIS National Adult and Influenza Immunization Summit 8 This document has been archived for historical purposes. (3/1/2020) https://www.cdc.gov/vaccines/acip/meetings/downloads/min-archive/min-2020-02-508.pdf Advisory Committee on Immunization Practices (ACIP) Summary Report February 26-27, 2020 NAM National Academy of Medicine NAP National Action Plan NAPNAP National Association of Pediatric Nurse Practitioners NAS National Academy of Sciences NCEZID National Center for Emerging and Zoonotic Infectious Diseases NCHHSTP National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention NCHS