Supplementary Table 3 Gene microarray analysis: PRL+E2 vs. control ID1 Field1 ID Symbol Name M Fold P Value 69 15562 206115_at EGR3 early growth response 3 2,36 5,13 4,51E-06 56 41486 232231_at RUNX2 runt-related transcription factor 2 2,01 4,02 6,78E-07 41 36660 227404_s_at EGR1 early growth response 1 1,99 3,97 2,20E-04 396 54249 36711_at MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F 1,92 3,79 7,54E-04 (avian) 42 13670 204222_s_at GLIPR1 GLI pathogenesis-related 1 (glioma) 1,91 3,76 2,20E-04 65 11080 201631_s_at IER3 immediate early response 3 1,81 3,50 3,50E-06 101 36952 227697_at SOCS3 suppressor of cytokine signaling 3 1,76 3,38 4,71E-05 16 15514 206067_s_at WT1 Wilms tumor 1 1,74 3,34 1,87E-04 171 47873 238623_at NA NA 1,72 3,30 1,10E-04 600 14687 205239_at AREG amphiregulin (schwannoma-derived growth factor) 1,71 3,26 1,51E-03 256 36997 227742_at CLIC6 chloride intracellular channel 6 1,69 3,23 3,52E-04 14 15038 205590_at RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 1,68 3,20 1,87E-04 55 33237 223961_s_at CISH cytokine inducible SH2-containing protein 1,67 3,19 6,49E-07 78 32152 222872_x_at OBFC2A oligonucleotide/oligosaccharide-binding fold containing 2A 1,66 3,15 1,23E-05 1969 32201 222921_s_at HEY2 hairy/enhancer-of-split related with YRPW motif 2 1,64 3,12 1,78E-02 122 13463 204015_s_at DUSP4 dual specificity phosphatase 4 1,61 3,06 5,97E-05 173 36466 227210_at NA NA 1,60 3,04 1,10E-04 117 40525 231270_at CA13 carbonic anhydrase XIII 1,59 3,02 5,62E-05 81 42339 233085_s_at OBFC2A oligonucleotide/oligosaccharide-binding fold containing 2A 1,59 3,00 2,06E-05 1047 49883 240633_at DOK7 docking protein 7 1,57 2,98 4,78E-03 356 18308 208892_s_at DUSP6 dual specificity phosphatase 6 1,57 2,97 6,40E-04 52 32655 223377_x_at CISH cytokine inducible SH2-containing protein 1,57 2,97 4,35E-07 282 13462 204014_at DUSP4 dual specificity phosphatase 4 1,56 2,95 4,10E-04 1233 15078 205630_at CRH corticotropin releasing hormone 1,55 2,92 6,68E-03 53 34957 225699_at SNORA9 small nucleolar RNA, H/ACA box 9 1,51 2,85 4,35E-07 949 36093 226837_at SPRED1 sprouty-related, EVH1 domain containing 1 1,49 2,81 3,90E-03 195 45215 235965_at BHLHB8 basic helix-loop-helix domain containing, class B, 8 1,46 2,76 1,39E-04 54 11880 202431_s_at MYC v-myc myelocytomatosis viral oncogene homolog (avian) 1,46 2,76 5,34E-07 1420 52419 243168_at PDZK1 PDZ domain containing 1 1,45 2,73 9,00E-03 372 19276 209869_at ADRA2A adrenergic, alpha-2A-, receptor 1,45 2,73 6,76E-04 157 41053 231798_at NOG noggin 1,44 2,72 1,00E-04 138 36617 227361_at HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 1,43 2,69 7,55E-05 530 29028 219743_at HEY2 hairy/enhancer-of-split related with YRPW motif 2 1,41 2,67 1,27E-03 954 10559 201110_s_at THBS1 thrombospondin 1 1,41 2,66 3,95E-03 121 41436 232181_at LOC153346 hypothetical protein LOC153346 1,41 2,65 5,91E-05 152 12821 203373_at SOCS2 suppressor of cytokine signaling 2 1,38 2,60 9,60E-05 60 30507 221223_x_at CISH cytokine inducible SH2-containing protein 1,37 2,58 1,80E-06 1989 10558 201109_s_at THBS1 thrombospondin 1 1,37 2,58 1,81E-02 130 18774 209360_s_at RUNX1 runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 1,37 2,58 6,31E-05 oncogene) 57 18978 209567_at RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 1,36 2,57 6,96E-07 27 49223 239973_at NA NA 1,36 2,56 2,10E-04 782 1246 1553982_a_at RAB7B RAB7B, member RAS oncogene family 1,35 2,56 2,72E-03 484 26964 217678_at SLC7A11 solute carrier family 7, (cationic amino acid transporter, y+ system) 1,34 2,53 1,11E-03 member 11 1532 14812 205364_at ACOX2 acyl-Coenzyme A oxidase 2, branched chain 1,32 2,50 1,08E-02 607 12820 203372_s_at SOCS2 suppressor of cytokine signaling 2 1,32 2,50 1,54E-03 90 10645 201196_s_at AMD1 adenosylmethionine decarboxylase 1 1,32 2,50 3,26E-05 37 18307 208891_at DUSP6 dual specificity phosphatase 6 1,31 2,49 2,15E-04 120 25918 216627_s_at B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1,30 2,46 5,63E-05 1 43 14246 204798_at MYB v-myb myeloblastosis viral oncogene homolog (avian) 1,29 2,45 2,20E-04 343 40003 230748_at ARSG arylsulfatase G 1,29 2,44 5,96E-04 920 13114 203666_at CXCL12 chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) 1,28 2,44 3,54E-03 62 12473 203023_at HSPC111 hypothetical protein HSPC111 1,28 2,43 3,50E-06 570 52017 242767_at LMCD1 LIM and cysteine-rich domains 1 1,27 2,42 1,42E-03 292 35291 226034_at NA NA 1,27 2,40 4,43E-04 1159 19328 209921_at SLC7A11 solute carrier family 7, (cationic amino acid transporter, y+ system) 1,26 2,39 5,89E-03 member 11 777 19096 209687_at CXCL12 chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) 1,24 2,37 2,69E-03 341 26244 216953_s_at WT1 Wilms tumor 1 1,23 2,35 5,92E-04 625 11913 202464_s_at PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 1,23 2,34 1,63E-03 2649 20489 211124_s_at KITLG KIT ligand 1,21 2,31 3,16E-02 163 32040 222760_at ZNF703 zinc finger protein 703 1,21 2,31 1,00E-04 85 35274 226017_at CMTM7 CKLF-like MARVEL transmembrane domain containing 7 1,19 2,28 2,70E-05 34 10646 201197_at AMD1 adenosylmethionine decarboxylase 1 1,17 2,25 2,13E-04 365 14861 205413_at MPPED2 metallophosphoesterase domain containing 2 1,16 2,23 6,48E-04 97 12887 203439_s_at STC2 stanniocalcin 2 1,16 2,23 3,77E-05 67 21145 211828_s_at TNIK TRAF2 and NCK interacting kinase 1,15 2,23 3,50E-06 663 52163 242913_at CLIC6 chloride intracellular channel 6 1,14 2,21 1,90E-03 66 14732 205284_at KIAA0133 KIAA0133 1,14 2,20 3,50E-06 74 23311 214011_s_at HSPC111 hypothetical protein HSPC111 1,14 2,20 9,34E-06 623 19270 209863_s_at TP73L tumor protein p73-like 1,13 2,19 1,62E-03 2838 45689 236439_at BCL6 B-cell CLL/lymphoma 6 (zinc finger protein 51) 1,12 2,18 3,65E-02 59 54579 65588_at LOC388796 hypothetical LOC388796 1,11 2,16 1,29E-06 1395 53057 243806_at NA NA 1,11 2,16 8,81E-03 287 38232 228977_at LOC729680 hypothetical protein LOC729680 1,11 2,15 4,36E-04 63 36761 227506_at SLC16A9 solute carrier family 16, member 9 (monocarboxylic acid 1,11 2,15 3,50E-06 transporter 9) 362 39653 230398_at TNS4 tensin 4 1,10 2,15 6,44E-04 71 13185 203737_s_at PPRC1 peroxisome proliferator-activated receptor gamma, coactivator- 1,10 2,14 6,61E-06 related 1 245 19211 209803_s_at PHLDA2 pleckstrin homology-like domain, family A, member 2 1,09 2,13 3,34E-04 95 27876 218590_at PEO1 progressive external ophthalmoplegia 1 1,09 2,13 3,77E-05 234 32226 222946_s_at C1orf135 chromosome 1 open reading frame 135 1,09 2,13 2,96E-04 99 22413 213109_at TNIK TRAF2 and NCK interacting kinase 1,09 2,13 4,20E-05 1382 40832 231577_s_at GBP3 guanylate binding protein 3 1,08 2,11 8,59E-03 100 33729 224467_s_at PDCD2L programmed cell death 2-like 1,08 2,11 4,54E-05 107 11596 202147_s_at IFRD1 interferon-related developmental regulator 1 1,07 2,10 4,99E-05 554 13734 204286_s_at PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 1,07 2,10 1,33E-03 132 11842 202393_s_at KLF10 Kruppel-like factor 10 1,07 2,10 6,40E-05 80 17117 207675_x_at ARTN artemin 1,07 2,10 1,88E-05 72 35115 225857_s_at LOC388796 hypothetical LOC388796 1,07 2,10 8,40E-06 665 44254 235004_at RBM24 RNA binding motif protein 24 1,07 2,10 1,91E-03 162 18128 208712_at CCND1 cyclin D1 1,07 2,10 1,00E-04 160 52780 243529_at MARS2 methionyl-tRNA synthetase 2, mitochondrial 1,07 2,09 1,00E-04 92 12494 203044_at CHSY1 carbohydrate (chondroitin) synthase 1 1,05 2,07 3,39E-05 303 53874 244623_at NA NA 1,05 2,07 4,68E-04 93 22411 213107_at TNIK TRAF2 and NCK interacting kinase 1,04 2,06 3,39E-05 596 18127 208711_s_at CCND1 cyclin D1 1,04 2,05 1,50E-03 242 34825 225567_at NA NA 1,03 2,04 3,17E-04 20 1286 1554037_a_at ZBTB24 zinc finger and BTB domain containing 24 1,03 2,04 1,95E-04 94 12569 203119_at CCDC86 coiled-coil domain containing 86 1,03 2,04 3,47E-05 83 32691 223413_s_at LYAR hypothetical protein FLJ20425 1,02 2,03 2,48E-05 202 13060 203612_at BYSL bystin-like 1,02 2,03 1,47E-04 1 14443 204995_at CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 1,02 2,03 1,58E-04 411 14735 205287_s_at TFAP2C transcription factor AP-2 gamma (activating enhancer binding 1,02 2,02 8,57E-04 protein 2 gamma) 283 48660 239410_at NA NA 1,01 2,02 4,10E-04 75 12384 202934_at HK2 hexokinase 2 1,01 2,02 1,01E-05 3037 21077 211756_at PTHLH parathyroid hormone-like hormone 1,01 2,01 4,19E-02 1543 45364 236114_at RUNX1 runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 1,01 2,01 1,09E-02 oncogene) 115 1285 1554036_at ZBTB24 zinc finger and BTB domain containing 24 1,01 2,01 5,23E-05 129 11595 202146_at IFRD1 interferon-related developmental regulator 1 1,01 2,01 6,17E-05 423 52460 243209_at KCNQ4 potassium voltage-gated channel, KQT-like subfamily, member 4 1,00 2,00 8,94E-04 300 12886 203438_at STC2 stanniocalcin 2 1,00 2,00 4,54E-04 1431 16100 206653_at POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) 0,98 1,98 9,17E-03 119 28724 219439_at C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta- 0,98 1,97 5,63E-05 galactosyltransferase, 1 768 30518 221234_s_at BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 0,98 1,97 2,64E-03 2 110 13070 203622_s_at PNO1 partner of NOB1 homolog (S.