INDEX Acquired immunodeficiency syndrome (AIDS), Cysteineproteinases, 34, 73, 87, 95,121,165,173, 241 177 Acrosome, 229 Cysteine switch, 6 Adamalysin, 1,253 Cytoskeleton, 105 Alkaline proteinase from Pseudomonas aerugi- nasa, 1,253 Elafin,44 Alzheimer's disease, 168, 261, 271 Elongation factor EF -I u, 209 Amino acid sequence identities, 5,45,65, 75 Endosomes, 261, 271 B-Amyloid precursor protein, 262 Endothelins, 143 Antigen processing, 52 Enkephalins, 145 Apoptosis, 165, 177 Extracellular matrix, 24, 47, 283 Argingipain, 34 Asparagine, 106 Factor G, 80 Aspartic proteinase, 247 Fertilization, 229 Astacin, 1,253 ATP, 51, 118, 139 Gelatinases, 6, 295 ATPase, 192 GTP, 118 ATP-dependent proteolysis, 187, 221, 232 GTP-binding protein, 212 ATP synthase subunit C, 121 Atrolysin, I Human immunodeficiency viruses (HIY-I), 233, Autocatalytic degradation, processing, 37, 243 241 Autophagy, 103, 113 HIY proteases, 241 HIY protease inhibitors, 242 Bacterial endopeptidases, 155,251 Batten disease, 121, 129 Influenza virus, 233 Botulism, 251 Interferon, 51 Interleukin-I B-converting enzyme (ICE), 165 C5A receptor, 155 Ischemia, 177 Calcium binding proteins, 58 Calpains and inhibitors, 95 Kallikrein, 25 Cancer, 282 KEKE proteins, 58 Cathepsin B, H, L, 92, 97,177,273,281 Kexin family proteases, 63 Cathepsin D, 274 Cathepsin G, 25 Leishmanolysin, 8 CED-3,166 Leupeptin, 105 Cementoin, 44 Lewy body disease, 261 Chymase,25 Limulus amebocyte lysate (LAL), 80 Chymotrypsin, 25 Lipofuscinoses, 129 Clp proteases, 51 Lipopolysaccharide (LPS), 79 Collagenases, I Lon proteases, 51 Crm-A,I73 Lysosomes, 103, 121, 133, 178,263,271 Cyc1in, 221 Cystatins, 73, 87, 180 u2-Macroglobulin,24 305 306 Index MAM domains, 14 Plasmepsins, 247 Malaria, 247 Porphyromonas gingivalis proteinases, 33 Matri1ysin, 1 Programmed cell death, 165 Matrix metalloproteinases (MMPs), 1,23,295 Proteasome, 51, 187, 197,229 Matrixins, 1 Protein synthesis, 209 Membrane-bound proteins, 13, 141 Psoriasis, 87 Meprins,13 a and B subunits, 13 Serralysin, 1 A and B, 16, 17 Serine proteases, 79, 173,229 Metalloe1astase, 23 Serine:pyruvate/alanine:glyoxylate aminotrans- Metalloendopeptidases, 13, 141 ferase (SPT/AGT), 137 Metzincins, 1 Serpins, 173 mnd mice, 131 Signal peptides/sequences, 14,37 Multicata1ytic protease (MCP), 51; see also Protea­ Strome lysin, 1 some Myoblast fusion, 149 Tetanus, 251 Thermolysin, 3, 25, 254 N-a-acetylated proteins, 209 Tissue inhibitors of metalloproteinases, (TIMPs), Neprilysin (endopeptidase-24.l1), 141 24,295 Neutrophil elastase, 25 a-toxin from S. aureus, 115 Trypsin, 25 OC-I and II, 74 Tryptase, 25 Okadaic acid, 103 Tryptase Clara, 234 Oryzain a and b, 75 Tumors, 281 PACE isoforms, 63 Ubiquitin, 181, 198,203,209,221,261 Papain, 34,75, 87 Ubiquitin C-terminal hydroJases, 203 PC 113, PC2, PC4, PC5/6, PC7, 63 PO 150606, 99 Vinblastine, 106 Peridontal disease, 33 Viruses, 233 Periodontitis, 155 Phytocystatins, 73 Zinc-binding motif, 1 Plasma (cell) membrane proteinases, 13,27, 141,295 Zinc peptidases, I, 141, 251 .