Contents Welcome 2 Programme Tuesday, 17 December 4 Wednesday, 18 December 8 Poster Communications 11 General Information 35 Abstracts Symposia 38 Oral Communications 45 Poster Communications 70 Future Physiology 2019: Translating Cellular Mechanisms into Lifelong Health Strategies 17–18 December 2019 Liverpool John Moores University, UK Organised by: Katie Hesketh and Mark Viggars Liverpool John Moores University, UK Welcome As co-organisers of Future Physiology 2019 and on behalf of Liverpool John Moores University and The Physiological Society, we would like to warmly welcome you to Liverpool as guests to attend the second Future Physiology conference. A conference dedicated to the development of early career researchers, which has been organised by early career researchers. The two day meeting will take place at Liverpool John Moores University, on the edge of Liverpool city centre, known worldwide for its culture and heritage in music, sport and art. Across the two days, we are delighted to offer four diverse sessions, eight keynote talks, 20 selected oral presentations and over 90 posters showcasing international experts and current early career researchers supporting the conference’s theme of ‘Translating Cellular Mechanisms into Lifelong Health Strategies’. We hope this conference will inspire you to engage in research and will help you feel a part of a wider community of physiologists. We are also offering four professional development sessions aimed specifically at early career researchers, along with an exciting evening social programme with a Beatles theme at the Hard Days Night Hotel, just a stone’s throw away from the iconic Cavern Club which will provide plenty of chance to network and meet other like-minded physiologists. Whatever your physiological interests, we encourage you to immerse yourself in all branches of physiology on show, network, ask thought-provoking questions and have conversations you wouldn’t normally have. Most of all, enjoy your time here in Liverpool, both as a physiologist and a tourist. Please immerse yourself in the friendly, festive atmosphere here in our wonderful city of Liverpool. If you have time, visit our two cathedrals, iconic waterfront 2 featuring the famous Liver Birds, and our comprehensive collection of galleries and museums. We would definitely recommend giving our local ‘scouse’ a try before you leave! We would like to sincerely thank The Physiological Society for giving us the opportunity to bring physiologists to Liverpool to share ideas, practices and experiences and their tireless support and knowledge in organising the event. We must also acknowledge supervisors and colleagues from near and far for promoting and sharing the event. We hope it is successful and that Future Physiology will continue to support early career researchers within the discipline of physiology. With best and festive wishes, Katie Hesketh and Mark Viggars Liverpool John Moores University, UK The Physiological Society, through its programme of scientific meetings, aims to support scientists in the United Kingdom, and across the world to communicate their latest research to peers, policymakers and funding bodies. These meetings are recognised for their high quality and impact on scientific discovery. 3 Tuesday, 17 December 08:45 Welcome and opening remarks Sue Deuchars, Chair, Conferences Committee, The Physiological Society, UK and Keith George, Associate Dean for Scholarship, Research and Knowledge Transfer, Faculty of Science, Liverpool John Moores University, UK Session 1: Omics approaches to investigating lifelong health and ageing Chairs Jonathan Jarvis and Jatin Burniston Liverpool John Moores University, UK 09:00 Contemporary issues in an ageing society and ageing research SA01 Claire Stewart, Liverpool John Moores University, UK 09:45 The role of epigenetics in regulating ageing skeletal muscle SA02 Robert Seaborne, Queen Mary University of London, UK 10:30 Break and networking 11:00 Individual and combined genetic variations are associated with in vivo and in vitro muscle damage in humans: a genetic approach to elucidate the mechanisms underpinning the response to exercise-induced muscle damage C01 Philipp Baumert, Technical University of Munich, Germany 11:15 Single-cell transcriptomic analysis revealed molecular signature of Pnmt-derived cardiomyocytes C02 Tianyi Sun, University of Oxford, UK 4 Tuesday, 17 December 11:30 A transcriptomic insight into the mechanism underlying the decrease in atrial ICa-L in heart failure C03 George Madders, University of Manchester, UK 11:45 A proteomic insight into liver dysfunction and metabolism during obesity C04 Ben Stocks, University of Copenhagen, Denmark 12:00 Muscle adaptation induced by endurance activity involves changes to protein abundance that are regulated by protein degradation as well as protein synthesis C05 Stuart Hesketh, Liverpool John Moores University, UK 12:15 Lunch, networking and poster viewing 13:00 Workshops (please choose one) The role of media in public engagement: nonsense or necessity? Greg Whyte OBE, Centre for Health and Human Performance Ltd, London, UK, and Liverpool John Moores University, UK Lower James Parsons Lecture Theatre Publishing for the first time Sally Howells, The Physiological Society, UK Upper James Parsons Lecture Theatre 5 Tuesday, 17 December Session 2: Novel mechanisms behind lifelong health Chairs Mark Viggars and Daniel Owens Liverpool John Moores University, UK 14:00 Circadian rhythms and molecular clock mechanisms: Working with time to develop new health strategies for humans SA03 Karyn Esser, University of Florida, USA 14:45 Physiological and structural changes in skeletal muscle and nerve- muscle interactions: the effects of ROS and ageing SA04 Natalie Pollock, University of Liverpool, UK 15:30 Break and networking 16:00 MicroRNA control of the circadian rhythm in heart rate C06 Cali Anderson, University of Manchester, UK 16:15 3D segmentation of the cardiac mitochondria and nuclei from the Greenland Shark (Somniosus microcephalus) insights into extreme longevity C07 Pierre Delaroche, University of Manchester, UK 16:30 The missing LINC to human healthy ageing: myonuclear architecture and mechanics in old age C08 Ed Battey, King’s College London, UK 16:45 The impact of replicative ageing and dietary flavonoids on C2C12 muscle cell mitochondrial function C09 Daniel Sadler, Liverpool John Moores University, UK 6 Tuesday, 17 December 17:00 Reduction in multiple cellular mechanisms during early replicatively aged C2C12 differentiation results in subsequent lack of myotube formation C10 Alexander Brown, Liverpool John Moores University, UK 17:15 Summary 17:30 Poster session with refreshments 20:00 Society Dinner Hard Days Night Hotel, Central Buildings, N John St, Liverpool L2 6RR To get in the festive mood, join us for a Beatles-inspired Christmas party at the Hard Days Night Hotel on Tuesday 17 December. You will be welcomed on arrival with a drink, followed by a three-course Christmas dinner with wine and soft drinks. Finish the night with a “Twist & Shout” with an interactive DJ, videos, competitions and an all-inclusive bar. 7 Wednesday, 18 December 08:00 Registration with arrival tea and coffee Session 3: Diet, obesity and disease Chairs Anton Wagenmakers and Matt Cocks Liverpool John Moores University, UK 09:00 The role of DNA damage in vascular aging SA05 Anton Roks, Erasmus University MC, Rotterdam, The Netherlands 09:45 Life style related disease, ageing and cardiovascular impairments SA06 Lasse Gliemann, University of Copenhagen, Denmark 10:30 Break and networking 11:00 Adipose tissue remodelling in response to obesity, exercise training and psychological stress C11 Susan Ige, University of Reading, UK 11:15 Fibre and sex specific differences in mitochondrial content and subcellular distribution and morphology of lipid droplets in skeletal muscle biopsies obtained from lean, obese and type 2 diabetes patients C12 Myfanwy Macey, Liverpool John Moores University, UK 11:30 Skeletal muscle weakness, atrophy, and abnormal blood flow response in an animal model of heart failure with preserved ejection (HFpEF) C13 Ever Espino Gonzalez, University of Leeds, UK 8 Wednesday, 18 December 11:45 Evaluation of the effects of WISP-1 on cardiac fibrosis mediated by cardiac fibroblasts via MMPs and TIMPs C14 Ze Li, University of Bristol, UK 12:00 A combination of major histocompatibility complex (MHC) I overexpression and Type I interferon (IFN) signature induces profound mitochondrial dysfunction in human skeletal muscle myoblasts C15 Anastasia Thoma, Manchester Metropolitan University, UK 12:15 Lunch, networking and poster viewing 12:45 Workshops (please choose one) Lifelong health stations Liverpool John Moores University staff and students Biomechanics Lab Postdoc challenges Emma Williams, EJW Solutions, Cambridge, UK Lower James Parsons Lecture Theatre Session 4: Exercise and lifestyle interventions for lifelong health Chairs Helen Jones and Katie Hesketh Liverpool John Moores University, UK 13:45 The effects of age and acute aerobic and resistance exercise on circulating T lymphocyte vitamin D receptor (VDR) expression in healthy males C16 Hannah Lithgow, Edinburgh Napier University, UK 9 Wednesday, 18 December 14:00 Absence of an ageing-related increase in fibre type grouping in master athletes and non-athletes C17 Guy Anselme Messa, Manchester Metropolitan University, UK 14:15 Are older adults at greater risk of the adverse musculoskeletal consequences of physical inactivity? C18 Juliette