Cancer Epidemiology, Biomarkers & Prevention Highlights October 2019 * Volume 28 * Number 10 Selected Articles from This Issue Disparities in Cancer Incidence and Trends Among American Indians and Alaska Natives Melkonian et al. Page 1604 The American Indian and Alaska Native (AI/AN) population bears a disproportionate burden of cancer incidence in the United States. To describe cancer incidence rates and trends in the AI/AN population compared with the non-Hispanic white population, Melkonian and colleagues used data from the central cancer registries linked with the Indian Health Service patient registration databases to identify cancers diagnosed between 2010 and 2015. The authors reported elevated rates of lung, colorectal, liver, kidney, and stomach cancer in the AI/AN population that varied by geographic region. This confirmed widening cancer disparities and highlighted missed opportunities for targeted interventions to reduce AI/AN cancer incidence. Incidence and Incidence Trends and Urinary Metabolites Demographic Burden of Survival of Gastric Cancer in Diagnostic and Prognostic HPV-Positive Taiwan in the Era of H. pylori of Intrahepatic Oropharyngeal Head and Eradication Cholangiocarcinoma Neck Cancers in the U.S. Mahal et al. Page 1660 Chang et al. Page 1694 Haznadar et al. Page 1704 Over the last two decades, there has been a Helicobacter pylori (H. pylori) eradication The etiology of intrahepatic rise in head and neck cancers in the has been shown to decrease gastric cholangiocarcinoma (ICC) is less well- oropharynx, due to the human adenocarcinoma risk. The epidemiology known compared to hepatocellular papillomavirus (HPV). These cancers of gastric lymphoma, which is also carcinoma (HCC). As ICC has poor require aggressive treatment with radiation, associated with H. pylori, and other rare prognosis and response to conventional surgery, or chemotherapy. This study by subtypes of gastric cancer is less clear. This therapy, identifying diagnostic and Mahal and colleagues is the largest study to study by Chang and colleagues prognostic biomarkers of this form of date on the incidence of HPV-positive comprehensively evaluated the incidence liver cancer is warranted. Liquid oropharyngeal head and neck squamous trend and the survival of gastric cancer in chromatography coupled to tandem mass cell carcinoma in the United States, finding Taiwan by histologic subtype. The spectrometry was used to measure non- that 75% of oropharynx cancers are related incidence trends of gastric cancer in invasively detected urinary metabolites in to HPV. The U.S. incidence of HPV-related Taiwan from 1996 to 2013 were evaluated subjects from the U.S. (NCI-MD cohort) throat cancer is 4.6 per 100,000 people, using data from the Taiwan Cancer and Thailand (TIGER-LC cohort). peaking amongst those ages 60 to 64, and Registry. The incidence of all gastric Haznadar and colleagues found that highest in white men where it is the 6th cancers in Taiwan decreased. However, the metabolites were significantly increased in most common incident nonskin cancer. incidence of adenocarcinoma and both, HCC and ICC in urine, but were The study shows that the favorable lymphoma, both of which are associated significantly higher in ICC in urine and in prognosis associated with HPV is restricted with H. pylori, showed diverging trends. tissue. Metabolite profile was robust at to oropharynx cancer rather than other head The disparity in the incidence trends classifying ICC in combination with a and neck cancers and provides data to warrants the need to search for additional clinically utilized marker, CA19-9, support education and prevention risk factors of gastric lymphoma. holding promise for diagnostic and strategies, including vaccination. prognostic evaluation of ICC. www.aacrjournals.org 1557 Downloaded from cebp.aacrjournals.org on September 29, 2021. © 2019 American Association for Cancer Research. Highlights of This Issue Cancer Epidemiol Biomarkers Prev 2019;28:1557. Updated version Access the most recent version of this article at: http://cebp.aacrjournals.org/content/28/10/1557 E-mail alerts Sign up to receive free email-alerts related to this article or journal. Reprints and To order reprints of this article or to subscribe to the journal, contact the AACR Publications Department Subscriptions at [email protected]. Permissions To request permission to re-use all or part of this article, use this link http://cebp.aacrjournals.org/content/28/10/1557. Click on "Request Permissions" which will take you to the Copyright Clearance Center's (CCC) Rightslink site. Downloaded from cebp.aacrjournals.org on September 29, 2021. © 2019 American Association for Cancer Research. .