TMG (Trimethylglycine) Powder™ TMG (also referred to as betaine) functions as an important tetrahydrofolate, which methyl donor. The donation of methyl groups by TMG is the substrate for can be very important for proper liver function, cellular methionine and SAMe replication, and detoxification reactions. Along with synthesis, as well as folate, TMG serves a vital role in methylation processes for the methionine in the body. It also functions as an osmoregulator and a methylation cycle. probable performance-enhancing aide.(1) Methylation is These methyl groups a vital biochemical process for many important biological thus serve to link the processes, including the metabolism of lipids and DNA. folate cycle (one-carbon The body’s ability to methylate declines with age.(2) metabolism) with Scientists suspect that adequate methylation of DNA can the methionine cycle prevent the expression of harmful genes. In addition to (sulfur metabolism).(7) its role as a methyl donor, TMG also plays a role in the In certain condition, manufacture of carnitine and serves to be protective these pathways of the kidneys.(3) A dose of 3g or more daily has been have been shown to function abnormally. The brain, correlated to homocysteine reduction. as compared to other organs, is theorized to be more vulnerable to oxidative insult as a consequence of the high Supplementation with methyl donors also serves to energy demands from oxidative metabolism, the high support a healthy lifestyle. Age associated progressive concentration of polyunsaturated fatty acids, and relatively (4) loss of DNA methylation is well documented, and it has low antioxidant enzyme status. It has thus been theorized been proposed that “reductions in methylation may be that once the buffering capacity of the cell is exceeded, (5) one of the mechanisms underlying the aging process.” damage occurs to proteins, and lipid membranes, resulting In an article published in the Proceedings of the National in the disruption of nuclear and mitochondrial DNA, and Academy of Sciences, it was noted that in all the subsequently cellular dysfunction or apoptotic cell death.(7) chromosomes assessed, “the average methylation level TMG may offer support in these instances. of all covered cytosine-phosphate-guanine (CpG) sites was lower in the centenarian sample (73.0%) than in the TMG can also be beneficial for the reduction of newborn one (80.5%).”(2) Additionally, the unmasked DNA homocysteine, particularly beneficial for those who methylation landscape shows that DNA obtained from a cannot properly metabolize homocysteine, resulting in 103 year old donor was more unmethylated overall than accumulation and extremely high levels, and potentially DNA from the same cell type obtained from a neonate. impacting cardiovascular function. Oral TMG functions to “methylate” homocysteine, allowing it to be removed from A positive association between the use of TMG and mood circulation. Furthermore, there is an increased frequency enhancement has also been noted as “a safe and effective of the number of conditions associated with altered DNA (6) tool” for mild despair. methylation. Methylenetetrahydrofolate reductase (MTHFR) is Common amounts used range from 100 mg per kg of body a major enzyme in the folate cycle. It functions to weight for infants, up to 3,000 mg daily for adults. convert 5,10-methylene tetrahydrofolate into 5-methyl (800) 437-1298 Viotron International 8122 E Fulton Street • Ada, MI 49301 [email protected] • www.viotron.com These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. LIT-204 Rev. 05/16 © Copyright 2016 References Supplement Facts 1. http://examine.com/supplements/Trimethylglycine/. Serving Size: 1 level teaspoon (approx. 3 g) Servings per Container: 80 2. Heyn H, Li N, Ferreira HJ, Moran S, Pisano DG, Gomez A, Diez Amount Per % Daily J, Sanchez-Mut JV, Setien F, Carmona FJ, Puca AA, Sayols Serving Value S, Pujana MA, Serra-Musach J, Iglesias-Platas I, Formiga F, Fernandez AF, Fraga MF, Heath SC, Valenciae A, Gut IG, Wang Trimethylglycine (glycine betaine) 3 g * J, Esteller M. Distinct DNA methylomes of newborns and *Daily Value not established centenarians. PNAS. June 26, 2012 109(26):10522-10527. Ingredients: Trimethylglycine. 3. Chambers ST. Betaines: their significance for bacteria and the This product is gluten and dairy free. renal tract. Clin Sci. 1995 88:25-7 [review]. 4. Bollati V, Joel Schwartz J, Wright R, Litonjua A, Letizia Tarantini RECOMMENDATION: One (1) level teaspoon per day mixed L, Suh H, Sparrow D, Vokonas P, Baccarelli A. Decline in with eight (8) ounces of cool water (or the beverage of your Genomic DNA Methylation through Aging in a Cohort of choice) or as otherwise directed by a healthcare professional. Elderly Subjects. Mech Ageing Dev. 2009 April 130(4):234–239. 5. http://www.the-scientist.com/?articles.view/articleNo/32184/ title/DNA-Methylation-Declines-with-Age. KEEP OUT OF REACH OF CHILDREN Store in a cool, dry area. 6. Di Pierro F, Settembre R. Preliminary results of a randomized Sealed with an imprinted safety seal for your protection. controlled trial carried out with a fixed combination of S-adenosyl-L-methionine and betaine versus amitriptyline in Product # 7250 Rev. 02/15 patients with mild depression. Int J Gen Med. 2015 Feb 4;8:73- 8. doi: 10.2147/IJGM.S79518. eCollection 2015. 7. Frye RE, James SJ. Metabolic pathology of autism in relation to redox metabolism. Biomarkers Med. 2014 8(3): 321–330 To place your order for TMG Powder™ or for additional information please contact us below. (800) 437-1298 Viotron International 8122 E Fulton Street • Ada, MI 49301 [email protected] • www.viotron.com These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. LIT-204 Rev. 05/16 © Copyright 2016.