DATA SHEET Reagent: Efavirenz Catalog Number: 4624 Lot Number: 01987 Release A Category: Provided: 20 mg Chemical Name: (S)-6-chloro-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)- 2H-3,1-benzoxazin-2-one Empirical C14H9ClF3NO2 Formula: Molecular 315.68 Weight: CAS Num: 154598-52-4 Solubility: DMSO; Chloroform; slightly soluble in toluene; insoluble in water. Mechanical Efavirenz is a non-nucleoside reverse transcriptase inhibitor of HIV-1. Efavirenz activity is Action: mediated predominantly by noncompetitive inhibition of HIV-1 reverse transcriptase. HIV-2 reverse transcriptase and human cellular DNA polymerases are not inhibited by efavirenz. Special COA Characteristics: Recommended Room temperature. Once resuspended, working aliquots can be stored at −20°C. Storage: ALL RECIPIENTS OF THIS MATERIAL MUST COMPLY WITH ALL APPLICABLE BIOLOGICAL, CHEMICAL, AND/OR RADIOCHEMICAL SAFETY STANDARDS INCLUDING SPECIAL PRACTICES, EQUIPMENT, FACILITIES, AND REGULATIONS. NOT FOR USE IN HUMANS. REV: 07/25/2014 Page 1 of 2 Contributor: Division of AIDS, NIAID. NOTE: Acknowledgment for publications should read "The following reagent was obtained through the NIH AIDS Reagent Program, Division of AIDS, NIAID, NIH: Efavirenz." This compound is restricted for “research purposes only” and is limited to 40 mg per requester per year. Not available for release to commercial organizations outside of the USA. Recipient agrees that the reagent (Efavirenz) use is permitted only as a standard for in vitro and/or studies in animals for inhibition of HIV replication. Last Updated July 25, 2014 ALL RECIPIENTS OF THIS MATERIAL MUST COMPLY WITH ALL APPLICABLE BIOLOGICAL, CHEMICAL, AND/OR RADIOCHEMICAL SAFETY STANDARDS INCLUDING SPECIAL PRACTICES, EQUIPMENT, FACILITIES, AND REGULATIONS. NOT FOR USE IN HUMANS. REV: 07/25/2014 Page 2 of 2.