Under the Auspices of the University of Medicine and Pharmacy CAROL DAVILA Volume 14 (17) Supplement 2019 Supplement Congress of the University of Medicine and Pharmacy CAROL DAVILA (October 10th-12th 2019) ISSN 2501-6903 ISSN-L 2501-6903 Volume 14 Supplement 2019 Editor-in-chief Deputy Editors Mircea CINTEZA (Romania) Dragos VINEREANU (Romania) Bogdan O. POPESCU (Romania) Senior Editors Ioanel SINESCU (Romania) Managing editors Alan G. FRASER (UK) Eliza Elena CINTEZA (Romania) Adriana ILIESIU (Romania) International Editorial Board Scientific Publishing Committee (University of Medicine and Pharmacy 1. Martin BURIAN (Austria) Carol Davila) 2. Gianfranco BUTERA (Italy) 3. Gheorghe CERIN (Italy) 1. Petru ARMEAN 4. Adrian COVIC (Romania) 2. Mihaela BALGRADEAN 5. Maurizio CUTOLO (Italy) 3. Ovidiu BAJENARU 6. Marco DIENA (Italy) 4. Mircea BEURAN 7. Heiner FANGERAU (Germany) 5. Dana BODNAR 8. Antonio FEDERICO (Italy) 6. Miron BOGDAN 9. Nicholas GOURTSOYIANNIS (Greece) 7. Alexandru BUCUR 10. Christopher GRANGER (USA) 8. Emanoil CEAUSU 11. Nicolae HANCU (Romania) 9. Delia CINTEZA 12. Marc HUMBERT (France) 10. Catalin CIRSTOIU 13. Mircea IVAN (USA) 11. Ileana CONSTANTINESCU 14. Vecsei LASZLO (Hungary) 12. Mircea DICULESCU 15. Gerald MAURER (Austria) 13. Ion FULGA 16. Serban MIHAILEANU (France) 14. Daniela FILIPESCU 17. Radu MIHAI (UK) 15. Mihai HINESCU 18. Lucian MIRON (Romania) 16. Ecaterina IONESCU 19. Piero PORTINCASA (Italy) 17. Ruxandra IONESCU 20. Schmidt THORSTEN (Germany) 18. Anca LUPU 21. Emil TOESCU (UK) 19. Dumitru LUPULIASA 22. Selman URANUES (Austria) 20. Dana MINCA 23. Victor VOICU (Romania) 21. Cristina PARVU DINU 22. Doina PLESCA 23. Bogdan A POPESCU 24. Adrian STREINU-CERCEL 25. Radu VLADAREANU IMPORTANT: • The journal is granted with B+ indicative by the CNCSIS. • The annual subscription comes along with a CMR certificate that offers you 5 EMC points. • Attention! The subscription can be solicited starting with any edition of the Medical Journal. For more information, please visit www.maedica.org. COPYRIGHT: All data, information and protocols from the official site www.maedica.org and MÆDICA - a Journal of Clinical Medicine may be reproduced, copied or adapted, freely and unconditionally, under the provision to mention the source as follows: “taken/adapted from MÆDICA - a Journal of Clinical Medicine.” PUBLISHER: MEDIA MED PUBLICIS Address of editorial staff: 10, Petofi Sandor, District 1, Bucharest Phone: +4031 101 13 221 Mædica J Clin Med. www.maedica.org ISSN: 2501-6903 ISSN-L: 2501-6903 MAEDICA - a Journal of Clinical Medicine A valuable Journal of clinical medicine, MAEDICA, has as a main purpose to enrich the quality of the medical practice in Romania through its scientific specialized content. From the summary: – the newest studies, research and discussions in clinical medicine nowadays; – scientific editorials that reflect an up-to-date synthesis of the results in the newest na- tional and international medical papers and research; – a number of clinical Romanian works and also articles from international collaborators; – the content of the Journal is in English only. The Journal has a great peer-review board and its content respects the international stan- dards of certified quality and originality of the articles. Subsequent to the CNCSIS accreditation, the publication was granted B+. At the present moment, MAEDICA - a Journal of Clinical Medicine is part of the inter- national data bases as follows: – PubMed – EBSCO COMITET DE ORGANIZARE / ORGANIZING COMMITTEE Acad. Ioanel SINESCU Pre¿edinte Congres, Rector / Congress Chairman, Rector Prof. Dragoş VINEREANU Pre¿edinte Congres, Prorector / Congress Chairman, Vice-Rector Prof. Mircea BEURAN Pre¿edintele Senatului / President of the Senate Prof. Ecaterina IONESCU Prorector / Vice-Rector Prof. Cătălina POIANĂ Prorector / Vice-Rector Prof. Viorel JINGA Prorector / Vice-Rector Prof. Bogdan O. POPESCU Prorector / Vice-Rector Prof. Dana MINCA Prorector / Vice-Rector Prof. Dumitru LUPULIASA Director CSUD / Director of the Committee for PhD University Studies Prof. Cătălin CÎRSTOIU Decan / Dean Prof. Doina DRĂGĂNESCU Decan / Dean Conf. Paula PERLEA Decan / Dean Conf. Maria Magdalena MOCANU Decan Facultatea de Moa¿e ¿i Asistente Medicale / Dean of the Faculty of Nurses and Midwives Prof. Ileana CONSTANTINESCU Director Departament Granturi ¿i Cercetare ªtiin¡ificå / Director of Department for Grants and Scientific Research Prof. Simona RUTA Prodecan Cercetare ªtiin¡ificå / Vice-Dean for Scientific Research Prof. Cristina PÂRVU Prodecan Cercetare ªtiin¡ificå / Vice-Dean for Scientific Research Prof. Andreea DIDILESCU Prodecan Cercetare ªtiin¡ificå / Vice-Dean for Scientific Research Prof. Mircea Ioan POPA Pre¿edinte Comisia de Etica Cercetårii / Chairman of the Research Ethics Committee Prof. Ovidiu BĂJENARU Pre¿edinte Comisia de Cercetare ªtiin¡ificå a Senatului / Chairman of the Senate’s Scientific Research Committee Prof. Victor PURCĂREA Director Editura Carol Davila / Director of Publishing House Carol Davila Prof. Cristian CURCĂ Pre¿edinte Comisia de Eticå ¿i Deontologie Universitarå / Chairman of the Academic Ethics and Deontology Committee Prof. Octavian BUDA Istoria medicinei / History of Medicine Dr. Silviu PIŢURU Secretar general / General Secretary Ing. Eugenia MIHAI Director administrativ / Administrative Director Mædica - a Journal of Clinical Medicine Content Abstracts of the posters exposed at the Congress of the University of Medicine and Pharmacy Carol Davila, Bucharest (October 10th-12th 2019) Young Investigator Award 3 Pharmacy 3 Surgical Specialities 6 Preclinical Specialities 9 Dental Medicine 12 Medical Specialities 17 Dental Medicine 17 Pharmacy 33 Preclinical and Laboratory Specialities 47 Medical Specialities 49 Surgical Specialities 97 Maedica A Journal of Clinical Medicine, Volume 14, Supplement, 2019 1 Mædica - a Journal of Clinical Medicine YOOUNGUNG INNVESTIGATORVESTIGATOR AWWARDARD PHARMACY ID 76 The Influence of Critical Quality Attributes of Raw ID 25 Principles of Green Materials on the Quality Target Chemistry Applied in Obtaining Product Profile of an Oral Schiff Bases with Potential Dosage Form Containing a BCS Therapeutic Effect II API Alexandra Teodora Bordei (Telehoiu)1, Diana 1,2 2 Camelia Nuta1, Miron Teodor Caproiu2, Florea Paul Dumitrascu , Elena Anghel , Alina 2 1 1 Dumitrascu2, Irina Zarafu3, Carmellina Daniela Ivancencu , Valentina Anuta , Mihaela Ghica , 1 1 Badiceanu1, Carmen Limban1 Lacramioara Popa , Cristina Dinu-Parvu 1 1Department of Pharmaceutical Chemistry, Faculty of Department of Physical and Colloidal Chemistry, Pharmacy, University of Medicine and Pharmacy Carol Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania Davila, Bucharest, Romania 2 2The Organic Chemistry Centre of Romanian Academy Department of Industrial Transfer and Technology, Costin D. Nenitescu, Bucharest, Romania Zentiva S.A., Bucharest, Romania 3Department of Organic Chemistry, Biochemistry and Objective: The objective of the study was to deter- Catalysis, Faculty of Chemistry, University of Bucharest, mine the impact of the critical quality attributes (CQA) Romania of active substance (API), excipients and packaging ma- terial on the Quality Target Product Profile (QTPP) of Objectives: The azomethine functional group of an oral dosage three strength proportional formulation the Schiff base structure is considered to be a versatile containing a low solubility, high permeability (BCS pharmacophore in the design and development of bio- Class II) active substance, by evaluating alternative active compounds. The purpose of this work was to manufacturers and sorts. find a microwave synthesis pathway to obtain Schiff Materials: Pilot and industrial batches of the same bases, starting from carprofen hydrazide, knowing that qualitative and quantitative formulation were manu- carprofen is a non-steroidal anti-inflammatory drug, factured by wet granulation. The quality of API, excipi- included in the class of propionic acid derivatives, that ents and packaging materials were evaluated according inhibits both COX-1 and COX-2. Microwave synthesis to European Pharmacopoeia monograph. The impact was chosen in order to reduce reaction time, and the of critical quality attributes of three active substance risk of side reactions, to increase yield and purity of the (such as particle size distribution, solubility, and poly- final compounds. morphism) on the impurity profile and in vitro dissolu- Methods: A mixture of (2RS)-2-(6-chloro-9H-car- tion profile of the finished product was also assessed. bazol-2-yl)propanohydrazide (carprofen hydrazide) Furthermore, the impact of particle size distribution and substituted aromatic aldehyde, in methanol abso- of two different sorts of the main filler were also evalu- lute, in the presence of catalytic amount of glacial ace- ated in correlation to the uniformity of content and tic acid was subjected to microwave irradiation, using a tablet aspect. Biotage 2.0 microwave synthesizer. The method in- The influence of two alternative packaging materi- cluded pre-stirring for 5 minutes and then irradiation als – cold sealing Aluminum foil and PVC/PVdC, was for 25 minutes, at a temperature of 90 °C. The final determined during the stability studies in ICH condi- product was recrystallized from isopropanol: water 1: tion for the finished product. 2. Results: Difference in terms of physical parameters The chemical structures of the new compound for the three manufacturers of API were