Magnesium Formulas PROFESSIONAL PRODUCT GUIDE NEW New products inside Delicious high-dose formulas Visit www.seroyal.com/genestrabrands to view the entire GENESTRA BRANDS line Scientifically sound, quality formulas. Genestra Brands is a leading-edge line of professional-grade nutraceuticals, helping North American healthcare practitioners restore, rebuild and maintain patient health for over 30 years. A trusted Seroyal brand. 112 Technology Drive, Pittsburgh, PA 15275 TEL: 1-888-737-6925 | FAX: 1-877-737-6925 | EMAIL: [email protected] | WEBSITE: www.seroyal.com These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, prevent any disease. The aim of this comprehensive product guide is to assist in building more effective and successful patient treatment strategies. The product guide is to be used as an adjunct to Seroyal Continuing Medical Education and is not intended to be utilized as a diagnostic tool nor replace any other required education. The remedies indicated in this product guide are potent medicines that can have profound therapeutic effects on patients. As with any intervention, the dosage may need to be adjusted for those with chronic conditions, very sensitive individuals and those taking multiple medications. Practitioners are solely responsible for the care and treatment provided to their own patients. The information provided by the speaker or speakers in the Seroyal Continuing Medical Education program together with any written material provided do not necessarily represent the views of Seroyal and are not intended as medical advice or an endorsement of any products. This information is for practitioner use only and is not meant to diagnose, treat, cure, prevent any disease or replace traditional treatment, and has not been evaluated by the FDA. Copyright © 2015 Seroyal. All rights reserved. No part of this information may be used or reproduced in any form or by any means, or stored in a database or retrieval system, or be distributed or replicated without express permission of Seroyal. Making copies of any part of this information for any purposes other than your own personal use is a violation of copyright law. 3130. Version 1. Printed 05/2015. TABLE OF CONTENTS Magnesium 101 Magnesium 101 ............................... 1 Magnesium formulas Magnesium intake Magnesium Complex Liquid ..................... 3 GENESTRA BRANDS has one of the largest portfolios of The primary dietary sources of magnesium are green Magnesium Glycinate Liquid ..................... 3 liquid magnesium supplements available. Great-tasting, vegetables, grains, nuts, soy beans and shell fish.3 Mag Cal Formula 2 .............................. 4 natural flavors complement the deliciously smooth However, magnesium intakes in Western countries are Mag Cal Plus .................................... 4 mouth-feel, for enhanced patient compliance. Capsule and consistently declining,3 due in part to industrial food Mag Cal Vanilla Liquid ........................... 5 tablet-based magnesium supplements are also available. processing and agricultural soil depletion.1 Daily intake Magnesium .................................... 6 has declined from approximately 410 mg in the 20th Cal Mag Liquid .................................. 6 Magnesium for century to just 200-300 mg.4 Cal Mag Raspberry Liquid ....................... 7 optimal health The adult Dietary Reference Intake (DRI) for magnesium Magnesium Source Comparison Chart ..... 8-9 Magnesium is the fourth most abundant mineral in the is 310-420 mg per day, however magnesium intakes are human body and is a cofactor in over 300 metabolic often well below the DRI, especially in older adults.5 Magnesium’s Physiological Effects. 10 reactions. A 70 kg person has approximately 20-24 g of magnesium, approximately 60% of which is stored Factors that influence 1,2 Cal Mag Vanilla Liquid + ........................12 in bones, where it acts as an interchangeable storage magnesium and calcium Cal Mag + D ...................................13 reservoir for the rest of the body. Around 35% of the requirements body’s magnesium is located in high tissues with high Multi Cal Mag ..................................13 Age and life stage: Net calcium absorption is as high as metabolic rates, including skeletal muscle, the brain, Super Cal Mag .................................14 60% in infants and young children (who need substantial heart, kidneys and liver.3 Magnesium is involved in amounts of the mineral to build bone density). the maintenance of normal blood pressure, glucose Absorption decreases to 15%–20% in adulthood and metabolism, muscle function, and bone integrity, among continues to decrease as people age. Recommended several other key physiological roles.4 calcium intakes are higher for females older than 50 years and for men and women older than 70 years.6, 7 REFERENCES 1. Seelig MS, Rosanoff A. The magnesium factor. New York: Avery, 2003. 2. Wacker WEC, Parisi AF. Magnesium metabolism. N Engl J Med 1968; 278: 658-63. 3. Schecter M. Magnesium and cardiovascular system. Magnesium Research. 2010; 23(2): 60-72 4. Volpe S. Magnesium in Disease Prevention and Overall Health. Advances in Nutrition. 2013; 378S–383S 5. Food and Nutrition Board, Institute of Medicine. (1997). Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride, Washington, DC: National Academy Press, 1997. 6. IOM (Institute of Medicine). 2011. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: The National Academies Press. 7. NHPD Monograph on Multi-Vitamin and Mineral. October 2007. 8. Straub DA. Calcium supplementation in clinical practice: a review of forms, doses, and indications. Nutr Clin Pract. 2007; 22: 286-296. Great tasting liquid magnesium formulas 2 Magnesium Complex Liquid Magnesium Glycinate Liquid Natural Tart Berry Flavor Natural Apple-Pomegranate Flavor MINERAL SUPPLEMENT MINERAL SUPPLEMENT Concentrated combination of three magnesium sources Magnesium glycinate formulation • Helps to maintain cardiovascular health† • Helps to maintain muscle function† • Promotes healthy glucose metabolism† • Helps to metabolize carbohydrates, protein and fat† • Supports muscle function† • Magnesium glycinate is a gentle form of magnesium that is less likely • Helps to promote magnesium intake to cause loose stools1,2† • Delicious natural blueberry-raspberry flavor Dissolves completely in water • No cloudy residue Magnesium Complex Liquid is a concentrated combination of three magnesium sources, • Great-tasting apple-pomegranate flavor including magnesium glycinate, citrate and malate. Magnesium is one of the most common nutritional deficiencies: insufficient magnesium intake is estimated to occur in Magnesium Glycinate Liquid contains 100% magnesium glycinate, a highly bioavailable1 1 approximately 2/3 of the American population. Magnesium plays an important role in and water-soluble form of magnesium. Its high solubility means that Magnesium Glycinate regulating insulin-mediated glucose uptake, and low serum magnesium levels are Liquid dissolves instantly into water without leaving behind a cloudy residue. Magnesium 2 associated with decreased insulin secretion. In healthy non-diabetic participants with low helps to maintain bone health by regulating the production of parathyroid hormone (PTH) serum magnesium levels, daily supplementation with 300 mg of magnesium has been and calcitriol, which helps to increase calcium absorption and minimize risk of calcium 3,4 shown to improve glucose metabolism and pancreatic β-cell function. Each tablespoon deficiency.3,4 In the United States, insufficient magnesium intake is estimated to occur in serving of Magnesium Complex Liquid provides 500 mg of magnesium to help maintain approximately 64% of men and 67% of women, with even higher levels of insufficient † cardiovascular health, promote healthy glucose metabolism and support muscle function. intake in elderly individuals.5 Magnesium glycinate (also known as magnesium bisglycinate) is an amino acid chelate of Supplement Facts magnesium and two glycine molecules. Evidence suggests that magnesium glycinate has a Serving Size 1 Tablespoon (15 ml)/ Servings per Container 30 significantly higher bioavailability than magnesium oxide, and is less likely to cause a 1,2 Each Tablespoon Contains %DV laxative effect. Supplementation with magnesium glycinate has been shown to decrease the severity of muscle cramping in pregnancy: in a clinical trial on 86 healthy pregnant Calories 30 Total Carbohydrate 5 g 2% t women with recurrent muscle cramps, supplementation with 300 mg of magnesium 2† Magnesium (magnesium glycinate/ citrate/malate) 500 mg 125% glycinate for 4 weeks reduced both the frequency and intensity of leg cramps. t Percent Daily Values (DV) are based on a 2000 calorie diet Other ingredients: Purified water, glycerin, xylitol, citric acid, DL-malic acid, natural flavor (blueberry/raspberry), xanthan gum, potassium sorbate, sodium citrate, organic stevia leaf extract Supplement Facts (glucosylsteviosides) Serving Size 1 Tablespoon (15 ml)/ Servings per Container 30 Each Tablespoon Contains %DV Recommended Dose Adults (19 years and older): Take one tablespoon daily or as recommended by your healthcare Calories 30 practitioner. Adolescents (9-18 years): Take ½ tablespoon daily or as recommended by your Total Carbohydrate 5 g 2%t healthcare practitioner. Magnesium (magnesium glycinate) 250 mg 63% t Percent Daily Values (DV)