Revised March 2018 CURRICULUM VITAE Petra Margarete Klinge, M.D. Ph.D. PERSONAL INFO Current Position Professor of Neurosurgery Alpert Medical School Brown University Attending Neurosurgeon Director, Pediatric Neurosurgery Division Director, Research Center and Clinic for Cerebrospinal Fluid Disorders Department of Neurosurgery Rhode Island Hospital 593 Eddy Street, APC 6 Providence, RI 02903 Phone (401) 793 9123 FAX (401) 444 2788 Email [email protected]; [email protected] EDUCATION 1986 -1988 Medical School Bochum, Germany 1988 - 1993 Medical School Kiel, Germany 1993 M.D. degree, Medical School Kiel 2002 Ph.D. degree Hannover Medical School, Germany POSTGRADUATE HONOURS AND AWARDS 2001 Best Poster Award at the 27th scientific annual meeting of the German Federation of women in medicine 09/2009 Top Abstract Award : Interaventricular implantation of alginate-encapsulated glukagon/like-peptide-1 (GLP-1) producing human mesenchymal stem cells in a double transgenic mouse model of AD. 2nd Annual meeting of the International Society of Hydrocephalus and CSF disorders 02/2014 Brite-Lite Winner 2013, Hasbro Children’s Hospital, RI http://www.hasbrochildrenshospital.org/About/Brite_Lite_Program.html 06/2014 Recognition for Exemplary Teaching in BIOL 3652 IMS II:Brain Sciences Brown University 1 PROFESSIONAL LICENSES AND BOARD CERTIFICATION 1994 German Medical License 2002 German Board Certification and Accreditation as Specialist for Neurosurgery 2008 Rhode Island Medical License (LA 00007, LA 00013 since 7/2014) ACADEMIC APPOINTMENTS 2002 - 2008 Assistant Professor of Neurosurgery Medical School Hannover Germany 2002 - present Associate Professor of Neurosurgery Medical School Hannover Germany 2009 - 2016 Associate Professor of Neurosurgery Warren Alpert Medical School, Brown University 2016 - present Professor of Neurosurgery, Warren Alpert Medical School Brown University 2011 Honorary Degree of Master of Arts ad eundum, Brown University 2013 Visiting Professor, Thomas Jefferson University Philadelphia, Department of Neurological Surgery HOSPITAL APPOINTMENTS 1993 – 1994 Department of Neurosurgery Westküstenhospital, Heide-Holstein, Germany (Residency) 1995 – 2002 Department of Neurosurgery Medical School Hannover, Germany (Residency) 2002 – 2004 Department of Neurosurgery International Neuroscience Institute Hannover (Fellowship) 2004 –2009 Senior Physician, Department of Neurosurgery International Neuroscience Institute Hannover 2009 - present Attending Neurosurgeon, Rhode Island Hospital, Providence, RI Additional hospital privileges: Miriam Hospital Providence, Butler Hospital, Providence, Women &Infants Hospital Providence 2016 - present Director of the Center for Cerebrospinal fluid disorders of the brain and spine, Rhode Island Hospital and Warren Alpert Medical School at Brown University OTHER APPOINTMENTS EDITORIAL BOARD 2013 – present Editor in Chief Elsevier Journal “Interdisciplinary Neurosurgery: Advanced Techniques and Case Management” 2009 – present Co-Editor Elsevier Journal “Clinical Neurology and Neurosurgery 2011 – present Editorial board member of “ Journal of Fluid Barriers in the CNS ” 2 since 7/2014 Associate Editor “Neurosurgery” – Neuroscience Section REVIEWER 2003- present Ad hoc reviewer of peer-reviewed journals: Neurosurgery, Journal of Neurosurgery, Acta Neurochirurgica, Journal of Neurology&Neurosurgery&Psychiatry, Journal of Cerebral Blood flow and Metabolism, Brain, Journal of Magnetic Resonance Imaging, European Journal of Neurology, Acta Neurological Scandinavica , Experimental Neurology, Neuroscience Letters, Journal of Fluids and Barriers of the CNS, Nature Clinical Practice ,Journal of Alzheimer´s disease, International Journal of Alzheimers disease, Journal of Neurogenetics, Journal of Neurosurgical Sciences, Neurosurgical Reviews, American Journal of Alzheimer’s Disease and other Dementias, Journal of Microencapsulation, BMC Neurology, Neurology, Child Neurology, World Neurosurgery. SOCIETY & CONGRESS PRESIDENCY, PI STUDY GROUPS, PI CLINICAL TRIAL, ADVISORY BOARD MEMBERSHIP, CONGRESS FACULTY 2000 – 2005 Co-Chair, International NPH-Advisory Board for evaluation of guidelines for the diagnosis and therapy of normal pressure hydrocephalus 2004-2009 Leading Principal Investigator of the “European Multicenter Study on Normal Pressure Hydrocephalus”, Clinicaltrials.org Identifier: NCT00874198 2008 President of “Hydrocephalus 2008”, Inauguration congress of the International society of Hydrocephalus and CSF disorders 2010 – 2012 President, International Society of Hydrocephalus and CSF Disorders. (www.ISHCSF.com) 2010 - present Faculty speaker and Panelist at the AANS Breakfast seminar “Contemporary Management for Adult Hydrocephalus”. 2012- present Principle Investigator in the multicenter “Efficacy of shunt surgery in normal pressure hydrocephalus: a randomized crossover study”, Participating centers: Johns Hopkins University, Rhode Island Hospital 2012 - present Co-Investigator of a prospective clinical trial "Development of normative standards for diagnosing coordination and gait problems in Normal Pressure Hydrocephalus" (IRB#1105-001), Department of Psychiatry and Human Behaviour, Butler Hospital, RI 2014 - present Member of the NINDS Common Data Element (CDE) Project Chiari Malformation (CM) Working Group (Chiari &Syringomyelia Foundation) 3 2014 - present Member of the Scientific, Eductaion & Advisory Board of the Chiari & Syringohydromyelia Foundation and Scientific Presenter at the Annual Colloquium and THINK TANK Meetings (http://csfinfo.org/about- us/scientific-education-advisory-board/) October 2015 Chair and Program Director of the 1st Aesculap Symposium in the Treatment and Management of Hydrocephalus. Chicago, IL, October 9th to 10th , 2015 2015 - present Member of the Neurology working group to identify Standard and Guidelines in the management of Ehlers-Danlos-Disease (http://eds2016.org/neurology- working-group/) 2016 Program director of the CME accredited “1st Annual CSF symposium” at the Warren Alpert Medical School of Brown University and Rhode Island Hospital (https://www.brown.edu/academics/medical/education/other- programs/continuing-medical-education/live-conferences/1st-annual- cerebrospinal-fluid-disorders-symposium) 2017 Program director of the CME accredited “2nd Annual CSF Symposium” at the Warren Alpert Medical School of Brown university & Rhode Island Hospital 2018 Program director of the CME accredited “3rd Annual CSF Symposium” at the Warren Alpert Medical School of Brown University & Rhode Island Hospital. RHODE ISLAND HOSPITAL COMITTEES 2010 – present Member of the Surgical Clinical Practice Committee RIH 2011 – present Liaison and member of the pediatric trauma committee 2010 – present Co-presenter interdisciplinary pediatric tumor board Since June 2016 Member of the search committee for PICU academic co-director position BROWN UNIVERSITY COMMITTEES 2012 – present Physician Mentor in the Medicine in Action Program (MIAP), Brown medical students and PLME undergraduate students shadowing Brown clinical faculty. 2010- present Faculty member of the Fetal Medicine @ Brown. BIOL 5720 2012 Member of the Brown University Fetal Medicine Program visiting faculty at The Fetal Center at Vanderbilt University, Nashville Tennessee MEMBERSHIP IN SOCIETIES 2013 – present Congress of Neurological surgeons (CNS) 4 2013 – present American Association of Neurological Surgeons (AANS) 2004 - present Society for Research into Intractable Hydrocephalus and Spina Bifida 2008 – present International Society Hydrocephalus and Cerebrospinal fluid disorders 2008-10 Founding Member and President Elect, 2010-12 President, 2012-14 Chair of the Nomination Committee 2011- present International Hydrocephalus Imaging Working Group (www.IHIWG.org) 2017 - present International Fellow of the AANS (IFAANS) PUBLICATIONS ORIGINAL PUBLICATIONS: 1. Klinge, P., D. Schmidt, and D. Harms, Fibromatosen im Kindesalter. Verh DtschGes Pathol, 1990. 74: p. 670. 2. Schmidt, D., et al., Infantile desmoid-type fibromatosis. Morphological features correlate with biological behaviour. J Pathol, 1991. 164(4): p. 315-9. 3. Brinker, T., et al., Sinusoidal intrathecal infusion for assessment of CSF dynamics in kaolin-induced hydrocephalus. Acta Neurochir (Wien), 1998. 140(10): p. 1069-75. 4. Klinge, P., et al., PET and CBF studies of chronic hydrocephalus: a contribution to surgical indication and prognosis. J Neuroimaging, 1998. 8(4): p. 205-9. 5. Klinge, P., et al., Cerebral blood flow in chronic hydrocephalus - a parameter indicating shunt failure- new aspects. Acta Neurochir (Wien), 1998. Suppl 71: p. 347-349. 6. Klinge, P., et al., Hirndurchblutungsmuster bei Patientenmit chronisch hydrocephaler Symptomatik vor und nach Shuntanlage. Geriat Forsch, 1998. 8: p. 7-15. 7. Schatzmann, C., et al., Treatment of elevated intracranial pressureby infuions of 10% saline in severlyhead injured patients. Acta Neurochir Suppl, 1998. 71: p. 31-33. 8. Klinge, P., et al., Superselektive Angiographie der Arteria occipitalis bei pulssynchronem Tinnitus. Klinische Neuroradiologie, 1999: p. 45-49. 9. Klinge, P.M., et al., Induction of heat shock protein 70 in the rat brain following intracisternal infusion of autologous blood: evaluation of acute neuronal damage. J Neurosurg, 1999. 91(5): p. 843-50. 10. Klinge, P.M., et al., A positron emission tomography study of cerebrovascular reserve before and after shunt surgery in patients with idiopathic chronic hydrocephalus. J Neurosurg, 1999. 91(4): p. 605-9. 11. Klinge, P.M.,