Resveratrol 98% Natural (Japanese Knotweed) Cambridge Commodities Chemwatch Hazard Alert Code: 3 Part Number: P33926 Issue Date: 04/03/2019 Version No: 1.1.23.11 Print Date: 29/09/2021 Safety data sheet according to REACH Regulation (EC) No 1907/2006, as amended by UK REACH Regulations SI 2019/758 S.REACH.GB.EN SECTION 1 Identification of the substance / mixture and of the company / undertaking 1.1. Product Identifier Product name Resveratrol 98% Natural (Japanese Knotweed) Chemical Name resveratrol Synonyms Not Available Chemical formula Not Applicable Other means of P33926 identification 1.2. Relevant identified uses of the substance or mixture and uses advised against The pharmacological activities and mechanisms of action of natural phenylpropanoid glycosides (PPGs) extracted from a variety of plants such as antitumor, antivirus, anti-inflammation, antibacteria, antiartherosclerosis, anti-platelet-aggregation, antihypertension, antifatigue, analgesia, hepatoprotection, immunosuppression, protection of sex and learning behavior, protection of neurodegeneration, reverse transformation of tumor cells, inhibition of telomerase and shortening telomere length in tumor cells, effects on enzymes and cytokines, antioxidation, free radical scavenging and fast repair of oxidative damaged DNA, have been reported in the literature. Phenylpropanoids (PPs) belong to the largest group of secondary metabolites produced by plants, mainly, in response to biotic or abiotic stresses such as infections, wounding, UV irradiation, exposure to ozone, pollutants, and other hostile environmental conditions. It is thought that the molecular basis for the protective action of phenylpropanoids in plants is their antioxidant and free radical scavenging properties. These numerous phenolic compounds are major biologically active components of human diet, spices, aromas, wines, beer, essential oils,propolis, and traditional medicine. Phenylpropanoids are ingredients of essential oils including those derived from anis, cinnamon bark, and clove They are often used for fragrances and aromatherapy. Significant correlation (54-86%) between antiplatelet potency and PPs content in the Relevant identified uses oils was found, the key role for this moiety in the control of haemostasis was suggested. As a confirmation of the importance of PP moieties in defining this kind of biological activity, traditional Chinese medicine preparations, identified as remedies to prevent blood stasis and thrombus formation were analyzed for their structure/effect relationships. The PPs isoeugenol, ferulic acid, elemicin, myristicin, ethyl gallate, and dihydroxyacetophenone were recognized as essential platelet protecting compounds. Many of these substances share both the shikimic acid biosynthetic pathway and a common PP backbone. It is thought that some beneficial health effects of PPs such as reducing the risk of cancer,osteoporosis and cardiovascular diseases may depend on their action as estrogen agonists/antagonists via estrogen receptors Estrogen receptor, a nuclear steroid receptor, binds estrogens and regulates the transcription of estrogen-responsive genes by interacting directly with DNA at estrogen response elements (ERE) of their promoters. PPs may act as nonsteroidal anti-inflammatory drug (NSAID)-like compounds. The COX-2 gene expression was dramatically inhibited by the synthesized dimer of ferulic acid. Phenylpropanoid glycosides (aka phenylethanoid glycosides, PPGs) originate from the shikimic acid-phenylpropanoid pathway and include simple monosaccharides,consisting of hydroxycinnamic acid and hydroxyphenylethyl (methoxyphenol) moieties Product code: P33926 Version No: 1.1.23.2 Page 1 of 20 S.REACH.GB.EN Lancaster Way Business Park Safety Data Sheet (Conforms to Regulation (EU) No 2020/878) Ely, Cambridgeshire, CB6 3NX, UK. Chemwatch: 9-638011 +44 (0) 1353 667258 Issue Date: 04/03/2019 [email protected] Print Date: 29/09/2021 www.c-c-l.com bonded to a central beta-glucopyranose by ester and glycosidic linkages, respectively,and more complex di-and trisaccharides with one or two additional sugars linked to the core glucose. Members of this compound class have shown a wide range of biological activity,including inhibition of plant pathogenic bacteria and fungi, antioxidant activity, tumour cell suppression, feeding stimulation of specialist herbivores and deterrence of generalist insects. Plant-derived PPGs were found to be effective in the selective inhibition of both tyrosinase activity and melanin synthesis in cultivated melanocytes without cytotoxic effects. The PPGs with antioxidant activities, such as acteoside and martynoside, exhibited antiproliferative, cytotoxic, antimetastatic and immunomodulatory properties Phenylpropanoids fulfill numerous physiological functions, essential for plant growth and development, as well as plant– environment interactions. The phenylpropanoid pathway is one of the most frequently investigated metabolic routes, among secondary metabolite. Phenylpropanoid metabolism generates an enormous array of secondary metabolites, based on the few intermediates of the shikimate pathway). The shikimate pathway is a source of phenylalanine and the entry point leading to the biosynthesis of phenylpropanoids. The so-called central phenylpropanoid pathway is defined by three enzymatic activities: (i) the phenylalanine deamination by phenylalanine ammonia-lyase (PAL) to the trans-cinnamic acid, (ii) the trans-cinnamic acid hydroxylation to the 4-coumarate, as a resulting from cinnamic acid 4-hydroxylase (C4H) activity, and finally (iii) the 4-coumarate conversion to the 4-coumaroyl-CoA by 4-coumarate-CoA ligase (4CL). The cooperating enzymes from the phenylpropanoid pathway were proposed to be organized into complexes called metabolons. The term “metabolon” encompasses multienzymatic complexes bound to the cellular structural elements – membranes. Most metabolon models are based on a dynamic, non-covalent aggregation of components on the endoplasmic reticulum (ER) surface. Organization of enzymes in metabolons is, at the cellular level, a way to optimize biosynthesis. It provides: (i) direct transport of intermediates between successive enzymes, hence increasing local concentration of the substrate around the enzyme active center, (ii) minimization of highly biologically active and potentially toxic intermediates within the cell, as well as (iii) coordination of reactions leading to different branches of pathways with shared enzymes or intermediates. In the phenylpropanoid pathway, intracellular interactions between biosynthetic enzymes were shown for the central phenylpropanoid pathway – where PAL and C4H colocalize in the ER. as well as for particular branches leading to the formation of (iso)flavonoids, monolignols, and anthocyanins. Stilbenoids are a group of naturally occurring phenolic compounds found in various plant species. Stilbenoids exert various biological activities ranging from cardioprotection, neuroprotection, anti-diabetic properties, depigmentation, anti-inflammation, cancer prevention and treatment. Stilbenoids are classified as phytoalexins, which are antimicrobial compounds produced de novo in plants to protect against fungal infection and toxins Although positive results were obtained in most cell culture and animal studies, further human studies are needed to substantiate beneficial effects of stilbenoids. Stilbenoids can be produced by bacteria stilbenoids and in various plants. They are, for example, secondary products of heartwood formation in trees that can act as phytoalexins (antimicrobial and often antioxidative substances). The stilbenoids, resveratrol and pterostilbene thought to exert anticancer effects, target genes with oncogenic function for de novo methylation and silencing, leading to inactivation of related signaling pathways (epigenetic regulation of oncogenic signals) Oligostilbenoids, typically stilbene dimers,trimers, tetramers, hexamers, heptamers and octamers (with various molecular frameworks resulting from different oxidative condensation of resveratrol monomer). show interesting biological activities, such as antibacterial, antiviral, and cytotoxic effects. The phenolic content in wine refers to the phenolic compounds—natural phenol and polyphenols—in wine, which include a large group of several hundred chemical compounds that affect the taste, colour and mouthfeel of wine. These compounds include phenolic acids, stilbenoids, flavonols, dihydroflavonols, anthocyanins, flavanol monomers (catechins) and flavanol polymers (proanthocyanidins). This large group of natural phenols can be broadly separated into two categories, flavonoids and non-flavonoids. Flavonoids include the anthocyanins and tannins which contribute to the color and mouthfeel of the wine. The non-flavonoids include the stilbenoids such as resveratrol and phenolic acids such as benzoic, caffeic and cinnamic acids. Resveratrol is found in highest concentration in the skins of wine grapes. Both red and white wine grape varieties contain resveratrol, but more frequent skin contact and maceration leads to red wines normally having ten times more resveratrol than white wines. Resveratrol and its derivatives produced by grape vines provides defense against microbes, and production can be further artificially stimulated by ultraviolet radiation. Uses advised against Not Applicable 1.3. Details of the supplier of the safety data sheet Registered company name Cambridge Commodities Address Lancaster Way Business Park, Ely, Cambridgeshire