CTN Bulletin Clinical Trials May 22, 2013 Network Volume 13 - 08 Trial Progress – Over 15,000! Greater New York Node News The Greater New York Node held its semiannual Node Trial enrollment numbers reflect study and Stakeholders Meeting May 3rd information as of May 21, 2013. at NYU School of Medicine. Participants included representatives from all of their Open Studies Community Treatment Providers, • CTN 0048 – CURB (Cocaine Use Reduction with New York University, Columbia University, Cornell Buprenorphine). Enrolled 302 (N=300). Enrollment University and The Rockefeller University, as well as completed – Completed follow-up, data lock next. leaders from the New York City Department of Health • CTN 0049 – Project HOPE (Hospital Visit as and Mental Hygiene, the New York City Health and Opportunity for Prevention and Engagement for Hospitals Corporation, the New York State Office of HIV-Infected Drug Users). Enrolled 475 (N=800). Alcoholism and Substance Abuse Services and the • CTN 0050 – Long Term Follow-up to the CTN Northeast and Caribbean Basin ATTC. Drs. Betty Tai 0027 (START) Study. Enrolled 813 (N=1,267). and Udi Ghitza joined from NIDA CCTN. Foci of the • CTN 0052 – BRAC (Buspirone for Relapse- meeting included: (1) integrating and coordinating Prevention in Adults with Cocaine Dependence). addictions screening and interventions across mainstream Enrolled 62 (N=60). Enrollment completed – in and specialty settings; (2) the use of technology to follow up phase. facilitate this; (3) scaling up and implementation research; and (4) an update on how addictions research Total Enrolled All Studies: 15,905 and practice were sustained in the wake of Hurricane Sandy. Betty and Udi talked about leveraging the EHR CTN 0047 Locked Database! (Electronic Health Record) to facilitate SBIRT in CTN 0047 – SMART-ED (Screening, Motivational mainstream and addictions settings; Jennifer McNeely Assessment, Referral, and Treatment in Emergency spoke on automated ACASI-administered screening Departments) started enrolling instruments for mainstream settings; Ned Nunes participants at 6 hospital emergency presented key findings from CTN-0044 on web-based departments in October 2010. The study interventions; and Stan Sacks and Mike Chaple talked reached its target enrollment of 1,285 patients 16 months about training and implementation on a State-wide level. later in February 2012. The one-year follow up Ellie Grossman, Babak Tofighi and Helena Hansen assessments were completed in February 2013. The discussed lessons learned from Hurricane Sandy, with a database was locked on May 16, 2013. The Lead particular focus on sustaining methadone and Investigator team is working on a final report to NIDA buprenorphine services from the perspectives of both and the DSMB for September 2013. Congratulations to patients and providers. all! Federal Offices Closed Delaware Valley Node Update The CCTN office and NIDA will be Dr. George Woody, Node PI, gave a presentation at the closed on Monday, May 27, 2013, for the APA annual conference, May 18-22, in San Francisco, Memorial Day holiday observance California, entitled: “Co-morbidity and Practical Issues of Treatment in the NIDA CCC and DSC Closed Clinical Trials Network.” This presentation The NIDA CCC (Clinical Coordinating Center) and DSC was co-authored by Dr. Tom McLellan and (Data and Statistics Center) offices at EMMES will be started with an overview of what we have learned about closed Monday, May 27, 2013 in observance of the psychiatric co-morbidities and how we learned it, then Memorial Day Holiday. The DSC 2 Help Desk will not moved on to the importance of substance use treatment be available that day, but DSC staff will respond to your for improving outcomes of other medical disorders, and requests when the office reopens the next business day. ended with a discussion of how the Affordable Health Care Act and the new DSM-5 criteria might work CTN is a program of the National Institute on Drug Abuse, together to facilitate the integration of treatment for part of the National Institutes of Health within the substance use disorders with general healthcare. Department of Health and Human Services. 1 Pacific Node Update - Taipei Conference Ph.D., Director of ISAP’s Center for Advancing The biennial Conference Series to Longitudinal Drug Abuse Research (CALDAR), David Promote Global Health is sponsored by Geffen School of Medicine at UCLA. NIDA, in collaboration with organizations in Asia and around the world. The first meeting, which was held April 17–19, 2013, in Taipei, Taiwan, was organized by UCLA in partnership with the Taiwan National Health Research Institutes (NHRI) and the Taiwan Food and Drug Administration (TFDA); 365 participants from 17 countries attended the meeting. This event was co-hosted by CTN 0050 Principal Investigator Yih-Ing Hser, Ph.D., Director of ISAP’s Center for Advancing Longitudinal Drug Abuse Research (CALDAR), David Geffen School of Medicine at UCLA. The theme was prevention and treatment of substance abuse and HIV, focusing on Asia and the Pacific Islands (API). The conference sessions covered the current status Special guests at the April 2013 Taipei meeting of the Conference of drug abuse and HIV in Asian countries as reported by Series to Promote Global Health were (from left) (1) Yun Wang, M.D., their representatives, featured strategies for meeting PhD., Director, Center for Neuropsychiatric Research, National Health Research Institutes, Taiwan; (2) Wen-Ing Tsay, Director, Division of challenges posed by these problems, and promoted Controlled Drugs, Food and Drug Administration, Department of international collaborative work on the prevention and Health, Executive Yuan, Taiwan; (3) Barry J. Hoffer, M.D., Ph.D., treatment of substance use and HIV in order to promote Case Western Reserve University School of Medicine, USA; (4) Gene- health in API and other populations. Jack Wang, M.D., Stony Brook University, USA; (5) Nora D. Volkow, M.D,. Director, National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), USA; (6) Wen-Ta Chiu, M.D., Ph.D. Drug use persists as a major problem that severely Minister, Department of Health, Executive Yuan, Taiwan; (7) Gilberto impacts the health of individuals and populations, locally Gerra, M.D., Chief, Drug Prevention and Health Branch, United and globally. The international Conference Series to Nations Office On Drugs and Crime (UNODC), Vienna; (8) Ing-Kang Promote Global Health is designed to share research Ho, Ph.D., China Medical University Hospital, Taiwan; (9) Hsing-Jien Kung, Ph.D., President, National Health Research Institutes, Taiwan; findings on substance abuse treatment and HIV (10) Jaw-Jou Kang, Ph.D., Director, Taiwan Food and Drug prevention, stimulate international collaborations, Administration, Department of Health, Executive Yuan, Taiwan; and particularly between the United States and API countries, (11) Yih-Ing Hser, Ph.D., University of California, Los Angeles, USA. and inform cultural aspects of treatment and prevention Future meetings will rotate among different locales in of substance abuse and HIV. These and upcoming activities are part of efforts to extend NIDA’s mission of Asia, the Pacific Islands, and the United States. Planning promulgating research-based interventions to improve for the 2015 conference is underway. Conference presentations and upcoming information will be posted at health services and promote health globally. www.caldar.org. Keynotes were delivered by Nora Volkow, M.D., NIDA Director, and Gilberto Gerra, M.D., Chief of the Drug New Funding Opportunities Prevention and Health Branch for the United Nations The following announcements may be Office on Drugs and Crime (UNODC). Local officials of interest to those in the CTN: (Wen-Ta Chiu, M.D., Ph.D., Minister, Department of • Health, Executive Yuan, Taiwan; Jaw-Jou Kang, Ph.D., Integration and Analysis of Diverse HIV-Associated Director, Taiwan Food and Drug Administration, Data (R03) (RFA-MH-14-200) Department of Health, Executive Yuan, Taiwan; Hsing- • NIDA Research Center of Excellence Grant Jien Kung, Ph.D., President, NHRI, Taiwan) opened the Program (P50) (PAR-13-222) conference with a welcome to the participants, and NIDA officials (Wilson Compton, M.D., M.P.E., Jacques • Notice to Clarify Number of Applications Allowed Normand, Ph.D., Betty Tai, Ph.D.) and many eminent per Institution for RFA-DA-14-004 Medications researchers presented cutting-edge research findings and Development Centers of Excellence Cooperative led discussions. Speakers from UCLA Integrated Program (U54) (NOT-DA-13-027) Substance Abuse Programs (ISAP) included Richard A. Rawson, Ph.D., and Walter Ling, M.D. This event was • Substance Use Disorders and Molecular Regulation co-hosted by Yun Wang, Ph.D., Director, Center for of Brain Energy Utilization (R01)(RFA-DA-14-005) Neuropsychiatric Research of NHRI, and Yih-Ing Hser, 2 New England Consortium Node News Day Two of the conference was the North Dakota Roger D. Weiss, MD , Shelly F. Addiction Counselor Association’s Spring Conference, Greenfield, MD, MPH, Hilary S. Connery, at which Drs. Somoza and Winstanley provided MD, PhD, Kevin Hill, MD, MHS, and R. presentations on novel medications to treat addiction, Kathryn McHugh, PhD from the New methadone, overdose prevention, barriers to MAT England Consortium Node were all adoption and using social media. Approximately 76 presenters at the McLean Hospital/Harvard Medical people attended the first day and 68 people attended the School