Author Manuscript Published OnlineFirst on April 24, 2020; DOI: 10.1158/1055-9965.EPI-19-1545 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. 1 Antibody responses to Helicobacter pylori and risk of developing colorectal 2 cancer in a European cohort 3 Running title (50/60 characters): Helicobacter pylori serology and colorectal cancer 4 Julia Butt†; 1) Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), 5 Heidelberg, Germany; E-mail: [email protected] 6 Mazda Jenab†; 1) International Agency for Research on Cancer (IARC-WHO), Lyon, France; E- 7 mail: [email protected] 8 Michael Pawlita; 1) Infections and Cancer Epidemiology, German Cancer Research Center 9 (DKFZ), Heidelberg, Germany; E-mail: [email protected] 10 Anne Tjønneland; 1) Diet, Genes and Environment, Danish Cancer Society Research Center, 11 Copenhagen, Denmark; E-mail: [email protected] 12 Cecilie Kyrø; 1) Diet, Genes and Environment, Danish Cancer Society Research Center, 13 Copenhagen, Denmark; E-mail: [email protected] 14 Marie-Christine Boutron-Ruault; 1) CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine 15 - UVSQ, INSERM, Université Paris-Saclay, 94805, Villejuif, France ; 2) Gustave Roussy, F-94805, 16 Villejuif, France; E-mail: [email protected] 17 Franck Carbonnel; 1) CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, 18 INSERM, Université Paris-Saclay, 94805, Villejuif, France; 2) Gustave Roussy, F-94805, Villejuif, 19 France; 3) Department of Gastroenterology, Bicêtre University Hospital, Assistance Publique 20 des Hôpitaux de Paris, Le Kremlin-Bicêtre, France; E-mail: [email protected] 21 Catherine Dong; 1) CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, 22 INSERM, Université Paris-Saclay, 94805, Villejuif, France; 2) Gustave Roussy, F-94805, Villejuif, 23 France; E-mail: [email protected] 24 Rudolf Kaaks; 1) Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 25 Heidelberg, Germany; E-mail: [email protected] 26 Tilman Kühn; 1) Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 27 Heidelberg, Germany; E-mail: [email protected] 28 Heiner Boeing; 1) Department of Epidemiology, German Institute of Human Nutrition Potsdam, 29 Rehbruecke; E-mail: [email protected] 30 Matthias B. Schulze; 1) Department of Molecular Epidemiology, German Institute of Human 31 Nutrition Potsdam, Rehbruecke, Nuthetal, Germany; 2) Institute of Nutrition Science, University 32 of Potsdam, Nuthetal, Germany; E-mail: [email protected] 33 Antonia Trichopoulou; 1) Hellenic Health Foundation, Athens; E-mail: atrichopoulou@hhf- 34 greece.gr 1 Downloaded from cebp.aacrjournals.org on September 25, 2021. © 2020 American Association for Cancer Research. Author Manuscript Published OnlineFirst on April 24, 2020; DOI: 10.1158/1055-9965.EPI-19-1545 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. 35 Anna Karakatsani; 1) Hellenic Health Foundation, Athens; 2) 2nd Pulmonary Medicine Dept., 36 School of Medicine, National and Kapodistrian University of Athens, “ATTIKON” University 37 Hospital, Haidari, Greece; E-mail: [email protected] 38 Carlo la Vecchia; 1) Hellenic Health Foundation, Athens; 2) Department of Clinical Sciences and 39 Community Health Università degli Studi di Milano, Italy; E-mail: [email protected] 40 Domenico Palli; 1) Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer 41 Research, Prevention and Clinical Network - ISPRO, Florence, Italy; E-mail: 42 [email protected] 43 Claudia Agnoli; 1) Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei 44 Tumori, Milan; E-mail: [email protected] 45 Rosario Tumino; 1) Cancer Registry and Histopathology Department, "Civic - M.P. Arezzo" 46 Hospital, ASP Ragusa, Italy; E-mail: [email protected] 47 Carlotta Sacerdote; 1) Unit of Cancer Epidemiology, Città della Salute e della Scienza University- 48 Hospital and Center for Cancer Prevention (CPO), Turin, Italy; E-mail: [email protected] 49 Salvatore Panico; 1) Dipartimento die Medicina Clinica e Chirurgia, Federico II University, 50 Naples, Italy; [email protected] 51 Bas Bueno-de-Mesquita; 1) Former senior scientist, Dept. for Determinants of Chronic Diseases 52 (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The 53 Netherlands; 2) Former associate professor, Department of Gastroenterology and Hepatology, 54 University Medical Centre, Utrecht, The Netherlands; 3) Former Visiting professor, Dept. of 55 Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, 56 United Kingdom; 4) Former Academic Icon / visiting professor, Dept. of Social & Preventive 57 Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; E-Mail: 58 [email protected] 59 Roel C.H. Vermeulen; 1) Julius Center for Health Sciences and Primary Care, Cancer 60 Epidemiology, University Medical Center Utrecht, Netherlands; E-mail: [email protected] 61 Inger T. Gram; 1) Faculty of Health Sciences, Department of Community Medicine, University of 62 Tromsø, The Arctic University of Norway, Tromsø, Norway; E-mail: [email protected] 63 Elisabete Weiderpass; 1) Office of the Director, International Agency for Research on Cancer 64 (IARC-WHO), Lyon, France; E-mail: [email protected] 65 Kristin Benjaminsen Borch; 1) Faculty of Health Sciences, Department of Community Medicine, 66 University of Tromsø, The Arctic University of Norway, Tromsø, Norway; E-mail: 67 [email protected] 68 Jose Ramón Quirós; 1) Public Health Directorate, Asturias, Spain; E-mail: 69 [email protected] 70 Antonio Agudo; 1) Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, 71 Catalan Institute of Oncology, Barcelona, Spain; E-mail: [email protected] 2 Downloaded from cebp.aacrjournals.org on September 25, 2021. © 2020 American Association for Cancer Research. Author Manuscript Published OnlineFirst on April 24, 2020; DOI: 10.1158/1055-9965.EPI-19-1545 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. 72 Miguel Rodríguez-Barranco; 1) CIBER of Epidemiology and Public Health (CIBERESP). Madrid, 73 Spain; 2) Andalusian School of Public Health (EASP). Granada, Spain; 3) Instituto de 74 Investigación Biosanitaria de Granada (ibs.GRANADA), Universidad de Granada, Granada, Spain; 75 E-mail: [email protected] 76 Carmen Santiuste; 1) CIBER of Epidemiology and Public Health (CIBERESP). Madrid, Spain; 2) 77 Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; E- 78 mail: [email protected] 79 Eva Ardanaz; 1) CIBER of Epidemiology and Public Health (CIBERESP). Madrid, Spain; 2) Navarra 80 Public Health Institute, Pamplona, Spain; 3) IdiSNA, Navarra Institute for Health Research, 81 Pamplona, Spain; E-mail: [email protected] 82 Bethany van Guelpen; 1) Department of Radiation Sciences, Oncology, Umeå University, Umeå, 83 Sweden; 2) Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden; E- 84 mail: [email protected] 85 Sophia Harlid; 1) Department of Radiation Sciences, Oncology, Umeå University, Umeå, 86 Sweden; E-mail: [email protected] 87 Liher Imaz; 1) Ministry of Health of the Basque Government, Public Health Division of Gipuzkoa, 88 Donostia-San Sebastian, Spain; 2) Biodonostia Health Research Institute, Donostia-San 89 Sebastian, Spain; E-mail: [email protected] 90 Aurora Perez-Cornago; 1) Cancer Epidemiology Unit, Nuffield Department of Population Health, 91 University of Oxford, Oxford, UK; E-mail: [email protected] 92 Marc J. Gunter; 1) International Agency for Research on Cancer (IARC-WHO), Lyon, France; E- 93 mail: [email protected] 94 Semi Zouiouich; 1) International Agency for Research on Cancer (IARC-WHO), Lyon, France; E- 95 mail: [email protected] 96 Jin Young Park; 1) International Agency for Research on Cancer (IARC-WHO), Lyon, France; E- 97 mail: [email protected] 98 Elio Riboli; 1) Department of Epidemiology and Biostatistics, School of Public Health, Imperial 99 College London, London, UK; E-mail: [email protected] 100 Amanda J. Cross; 1) Department of Epidemiology and Biostatistics, School of Public Health, 101 Imperial College London, London, UK; E-mail: [email protected] 102 Alicia K. Heath; 1) Department of Epidemiology and Biostatistics, School of Public Health, 103 Imperial College London, London, UK; E-mail: [email protected] 104 Tim Waterboer†; 1) Infections and Cancer Epidemiology, German Cancer Research Center 105 (DKFZ), Heidelberg, Germany; E-mail: [email protected] 106 David J. Hughes*†; 1) Cancer Biology and Therapeutics Group, School of Biomolecular and 107 Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland; E-mail: 108 [email protected] 3 Downloaded from cebp.aacrjournals.org on September 25, 2021. © 2020 American Association for Cancer Research. Author Manuscript Published OnlineFirst on April 24, 2020; DOI: 10.1158/1055-9965.EPI-19-1545 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. 109 † These authors contributed equally to this work. 110 Disclaimer: Where authors are identified as