25-28 October 2018 Regnum Carya Hotel, Antalya - Turkey SELECTED CASES www.endobridge.org 2018 STEERING COMMITTEE Susan Mandel President, ES Dolores Shoback Chair, Scientific & Educational Programs Committee, ES Aart J Van Der Lely President, ESE Jens Bollerslev Immediate Past Chair, Education Committee, ESE Camilla Schalin-Jäntti Chair, Education Committee, ESE Sevim Gullu President, SEMT Sadi Gundogdu Past President, SEMT Bulent O. Yildiz Founder & President, EndoBridge® Dilek Yazici Scientific Secreteriat, EndoBridge® Ozlem Celik Scientific Secreteriat, EndoBridge® 2 25 - 28 October, 2018 Antalya - Turkey 2018 SCIENTIFIC PROGRAM Friday, 26 October 2018 08.40 - 09.00 Welcome and Introduction to EndoBridge 2018 MAIN HALL Chairs: Sadi Gündoğdu, Aj van der Lely 09.00 - 09.30 Difficult cases with anterior pituitary tumors: Beyond the guidelines - Jens Otto Jorgensen 09.30 - 10.00 Radiological examination of the sellar region - Jean-François Bonneville 10.00 - 10.30 Evaluation and management of hypophysitis - Niki Karavitaki 10.30 - 11.00 Fluid and electrolyte balance following pituitary surgery - Alper Gürlek 11.00 - 11.20 Coffee Break 11.20 - 12.50 Interactive Case Discussion Sessions HALL A Pituitary - Niki Karavitaki, Züleyha Karaca HALL B Adrenal - Richard Auchus, Serkan Yener HALL C Neuroendocrine tumors- Camilla Schalin-Jäntti, Djuro Macut HALL D Male Reproductive Endocrinology - Dimitrios Goulis, Özlem Üstay Tarçın 12.50 - 14.00 Lunch 14.00 - 15.30 Interactive Case Discussion Sessions HALL A Pituitary - Jens Otto Jorgensen, Jean-François Bonneville HALL B Adrenal - Gary Hammer, Nur Kebapçı HALL C Neuroendocrine tumors - Wouter de Herder, Camilla Schalin-Jäntti HALL D Female Reproductive Endocrinology - Ricardo Azziz, Füsun Saygılı 15.30 - 15.50 Coffee Break MAIN HALL Chairs: Dimitrios Goulis, Melek Eda Ertörer 15.50 - 16.20 Approach to challenging adrenal masses - Gary Hammer 16.20 - 16.50 Polycystic ovary syndrome throughout a woman’s life - Ricardo Azziz 16.50 - 17.20 Consequences of steroid abuse for exercise training- How to approach? - Richard Auchus 17.20 - 17.50 Sequencing of treatments for neuroendocrine tumors - Wouter de Herder 3 25 - 28 October, 2018 Antalya - Turkey 2018 SCIENTIFIC PROGRAM Saturday, 27 October 2018 MAIN HALL Chairs: Okan Bülent Yıldız, Dale Abel 09.00 - 09.30 On the road from insulin resistance, prediabetes and diabetes-when do we initiate treatment? - Oğuzhan Deyneli 09.30 - 10.00 Guidelines in type 2 diabetes - Do they all agree? - Harald Sourij 10.00 - 10.30 What is new in insulin therapy of diabetes? - Tzvetalina Tankova 10.30 - 11.00 Diabetes therapies and heart failure - Dale Abel 11.00 - 11.20 Coffee Break 11.20 - 12.50 Interactive Case Discussion Sessions HALL A Diabetes - Harald Sourij, Tzvetalina Tankova HALL B Bone - Calcium - Ghada El-Hajj Fuleihan, Ayşe Kubat Üzüm HALL C Thyroid - Susan Mandel, Laura Fugazzola HALL D Obesity - lipids - Edita Stokic, Sinem Kıyıcı 12.50 - 14.00 Lunch 14.00 - 15.30 Interactive Case Discussion Sessions HALL A Diabetes - Dale Abel, Serpil Salman HALL B Bone - Calcium - Zhanna Belaya - Jens Bollerslev HALL C Thyroid - Elizabeth Pearce, Robin Peeters HALL D Obesity - lipids - Jøran Hjelmesæth, Volkan Yumuk 15.30 - 15.50 Coffee Break MAIN HALL Chairs: Susan Mandel, Mine Adaş 15.50 - 16.20 Perplexing thyroid function tests - Robin Peeters 16.20 - 16.50 How do we approach thyroid disorders during pregnancy? - Elizabeth Pearce 16.50 - 17.20 Approach to thyroid nodules - Susan Mandel 17.20 - 17.50 Thyroid microcarcinomas - to treat or not to treat? - Laura Fugazzola 4 25 - 28 October, 2018 Antalya - Turkey 2018 SCIENTIFIC PROGRAM Sunday, 28 October 2018 MAIN HALL Chairs: Güzin Fidan Yaylalı, Stavroula A. Paschou 09.00 - 09.30 Questioning the long term outcomes of bariatric surgery - Jøran Hjelmesæth 09.30 - 10.00 We are all becoming obese – Do we know why? - Dilek Yazıcı 10.00 - 10.30 Ghrelin and human evolution - AJ Van der Lely 10.30 - 11.00 Management of dyslipidemia - beyond statins - Edita Stokic 11.00-11.20 Coffee Break MAIN HALL Chairs: Jens Bollerslev, Mustafa Sait Gönen 11.20 - 11.50 Update on Vitamin D - skeletal and nonskeletal effects - Ghada El-Hajj Fuleihan 11.50 - 12.20 Diabetes and bone - Zhanna Belaya 12.20 - 12.50 Drugs and bone - Stefano Frara 12.50 - 13.20 FGF23 - An update in pathophysiology and new treatments - Diana Ovejero 13.20 - 13.30 Closing comments and adjourn 5 25 - 28 October, 2018 Antalya - Turkey 2018 SELECTED CASES DATE TIME HALL SESSION TITLE O - 01 / Does MEN1 variant (p.Ser183Cys) affect the response to DA therapy in a young prolactinoma patient without other components of MEN1 syndrome? 26.10 11.20 - 12.50 A Pituitary O - 02 / A novel mutation in kisspeptin receptor gene causing hypogonadotropic hypogonadism: a case report O - 03 / When an ‘ordinary’ tumour starts misbehaving… O - 04 / Acute Adrenal Insufficiency Associated Tuberculosis 26.10 11.20 - 12.50 B Adrenal O - 05 / Primary Aldosteronism with Adrenal Adenoma in Pregnancy O - 06 / A Case of Malignant Insulinoma: a multimodal treatment and prolonged survival Neuroendocrine O - 07 / Metastatic MEN1 Syndrome treated with Lutetium-177: 26.10 11.20 - 12.50 C tumors A Case Report O - 43 / A challenging search for the origin of recurrent hypoglycemias Male reproductive O - 08 / Familial Testotoxicosis in a child: A Case Report 26.10 11.20 - 12.50 D endocrinology O - 09 / A Case of Adult Man Whose Limbs are Still Growing O - 11 / Long-term clinical course and therapeutic results of a 57 years old X-LAG patient O - 12 / Primary Granulomatous Hypophysitis Masquerading as 26.10 14.00 - 15.30 A Pituitary Cabergoline-Resistant Prolactinoma O - 13 / Metastatic Lung Cancer Presenting With Panhypopituitarism O - 14 / A Rare Challenge: A Case of Malignant Pheochromocytoma O - 15 / Severe and prolonged hyperkalemia following unilateral 26.10 14.00 - 15.30 B Adrenal adrenalectomy for primary hyperaldosteronism O - 16 / ACTH-independent Macronodular Adrenal Hyperplasia; A Rare Case with Bilateral Adrenal Masses O - 17 / Abdominal Paragangliom and Hyperparathyroidism in a Pheochyromocytoma Patient Neuroendocrine O - 18 / Bronchial neuroendocrine tumor causing acromegaly--- 26.10 14.00 - 15.30 C tumors a rare occurrence O - 19 / Peptide receptor radionuclide therapy (PRRT) - a‘ miracle’ treatment for malignant insulinoma Female reproductive O - 20 / Urogenital Anomaly in an Adult Renal Transplant 26.10 14.00 - 15.30 D endocrinology Candidate: Clitoromegaly or Hypospadias? 6 25 - 28 October, 2018 Antalya - Turkey 2018 SELECTED CASES DATE TIME HALL SESSION TITLE O - 23 / The last weapon in the diabetic foot ulcer treatment: stem cell therapy O - 24 / A practical clinic case of using quantitative lifestyle 27.10 11.20 - 12.50 A Diabetes management and glucose predictions to control chronic metabolic conditions (part of math-physical medicine) O - 25 / A case of anti-GAD negative diabetic ketoacidosis O - 26 / Delayed diagnosis of hypophosphatemic rickets in an adult female 27.10 11.20 - 12.50 B Bone/Calcium O - 27 / Brown tumor of the maxilla and mandible as atypical presentation of primary hyperparathyroidism O - 29 / Werner syndrome as a rare cause of pituitary insufficiency and papillary thyroid carcinoma O - 30 / High Calcitonin levels in medullary thyroid cancer does 27.10 11.20 - 12.50 C Thyroid not always mean distant metastasis O - 31 / A case with langerhans cell histiocytosis having papillary microcarcinoma of thyroid: two birds in one nest O - 32 / Metabolic deterioration during prospective follow-up in an extremely rare case of congenital generalized lipodystrophy 27.10 11.20 - 12.50 D Obesity / Lipids type 4 O - 33 / Peripheral polyneuropathy after sleeve gastrectomy O - 35 / Rogers syndrome: A rare cause of monogenic diabetes mellitus 27.10 14.00 - 15.30 A Diabetes O - 36 / Unexplanied Hypoglycemia in a Patient With Type 1 Diabetes O - 37 / Severe hyperglycemia during massive transfusion O - 38 / Severe hypercalcemia due to primary hyperparathyroidism manifested with myxedema coma and 27.10 14.00 - 15.30 B Bone/Calcium rabdomyolisis resulting in multiorgan failure O - 39 / Hypocalcemia; a rare cause of dilated cardiomyopathy O - 41 / Familial Dysalbuminemic Hyperthyroxinemia in a Turkish Family 27.10 14.00 - 15.30 C Thyroid O - 42 / A case report: Metabolic regression in a metastatic medullary thyroid cancer case treated with Lu-177 O - 34 / A Rare But Severe Post-bariatric Surgery Complication 27.10 14.00 - 15.30 D Obesity / Lipids ’Hepatic Impairment’ should not be missed! 7 25 - 28 October, 2018 Antalya - Turkey 2018 ORAL PRESENTATIONS 8 25 - 28 October, 2018 Antalya - Turkey 2018 O-01 Pituitary DOES MEN1 VARIANT (P.SER183CYS) AFFECT THE RESPONSE TO DA THERAPY IN A YOUNG PROLACTINOMA PATIENT WITHOUT OTHER COMPONENTS OF MEN1 SYNDROME? GÜLŞAH YENIDÜNYA YALIN1, FEYZA TUNCER2, SEMA ÇIFTÇI DOĞANŞEN3, SEMA YARMAN1 1 ISTANBUL UNIVERSITY, ISTANBUL FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DIVISION OF ENDOCRINOLOGY AND METABOLIC DISEASES, CAPA ISTANBUL, TURKEY 2 ISTANBUL UNIVERSITY AZIZ SANCAR INSTITUTE OF EXPERIMENTAL MEDICINE, DEPARTMENT OF GENETICS, CAPA, ISTANBUL, TURKEY 3 UNIVERSITY OF HEALTH SCIENCES BAKIRKOY DR. SADI KONUK TRAINING AND RESEARCH HOSPITAL, DEPARTMENT OF INTERNAL MEDICINE, DIVISION OF ENDOCRINOLOGY AND METABOLIC DISEASES, ISTANBUL, TURKEY. INTRODUCTION: Pituitary adenomas (PAs) are rarely seen in pa- atively DA therapy was not initiated, PRL returned normal (19 ng/ tients younger than 20 years old, where prolactinomas comprise dl). Mensturation