DIGS Comparison Guide II DIAGNOSTIC INTERVIEW FOR GENETIC STUDIES (DIGS) Purpose of Document: This document is to serve as a harmonized product representing all content from Versions 3.0/B (Study 1), 3.0 GenRED I (Study 7), 3.01 MD GenRED II v1 (Study 52, 8/2005), 3.01 MD GenRED II v2 (Study 52, 4/2006), 3.0 Revised 7 (Study 42), 3.0/Anorexia Nervosa (Study 24), and 4.0/BP (Study 40). Please note: 3.0/Anorexia Nervosa (Study 24) is only present in sections A, B, E, F, G, H, O, N, X, and Y. There are minimal differences between 3.0 GenRED I (Study 7), 3.01MD GenRedII v1 (Study 52), and 3.01 GenREDII v2 (Study 52). These differences are noted with unqiue square designs, which are explained under the "color system" heading. There is a section at the end of this instrument with additional materials from these three versions that are not in the other versions. There is a seprerate harmonized document representing all content from Versions 1.0 (Study BP 0/Study SZ 0), 2.0 (Study BP 0, Study 1/Study SZ 0/Study 2), 2.1 MGS (Study 6), 2.2 MGS (Study 29), 3.0 (Study 22), and 4.0 (Study 22) of the DIGS. DIAGNOSTIC INTERVIEW FOR GENETIC STUDIES (DIGS) Document Information: This document is to be read as any other DIGS instrument. The sections are represented the same in this product as they are in each version, beginning with Section A and ending with Section AA (followed by a reference section and an appendix) . Instrument Questions In cases where questions differ among versions, there will be multiple forms of these questions presented so the reader not only knows what question is represented in what version, but also how the questions vary among the versions. In some of these instances, differences in font can be observed. Red Lines A red line coming down from a set of squares on the right side of the document indicates that all of the text to the left of this line applies to that same set of squares. Once a new set of squares is introduced, if there is not a large group of text that applies to this particular set (i.e., more than 1-2 questions), then there will not be a line. = grouping is ongoing = grouping has ended Page Numbers When an interviewer note tells the reader to skip to a different section, the page that the section should begin on is not always the same among all of the versions. Therefore, page numbers referenced in the text have been deleted. Page numbers in the top right corner of this document refer only to this document. Question Numbers If comparing this harmonized document to a particular DIGS instrument, question numbers that are referred to in the document (e.g., when an interviewer note tells the reader to skip to "Question X") may vary. This is due to questions being added/omitted in a particular version(s) and not the others. Although the actual number might not be the same, the content is. Therefore, when one version asks the reader to skip to Question X and another version says to skip to Question Y, the reader will be directed to the appropriate location. When multiple (unrealted) questions from other versions have been added and it is difficult to properly display these questions with the intended question number (e.g., when question #60 in version "1" is replaced with multiple questions from version "2," but these multiple questions are still numbered as "60, 61, 62," etc. yest the content is different), these numbers will be underlined with a red line to signify that they have been added to the document as a way to avoid confusion. Pg. # = question has been added to section DIAGNOSTIC INTERVIEW FOR GENETIC STUDIES (DIGS) Color System: Each DIGS version identified in this document is represented by a colored square. Next to each question (interviewer note/open-ended response/etc.) there is a set of 5 squares. If the square is filled in with a color, that indicates that the question is present in the version that the particular square represents (see key below). If the square is empty, that could mean that the question is not present in that version. An empty square could also indicate when the text in a particular version is not identical to the original text. In this case, the different text will be present in the same vincinity with the addition of a colored square that represents the DIGS version (with empty squares to indicate the versions that this added text would not be found in). At the beginning of each section it is identified which version will be represented. This is to let the reader know when a particular version has been omitted from one of the DIGS versions in rather than the questions being present but different. In rare occasions, an entire section of one version might be too different to be harmonized, which would also result in an additional section with just the one version represented (i.e., section A1). Key: 3.0 3.0/3.01 3.0 3.0 4.0 /B GRI/II* R7 AN /BP = all three versions (3.0 GenRED I, 3.01 Md GenRED II v1, 3.01 MD GenRED II v2) = ONLY 3.01 MD GenREDII v1 = ONLY 3.01 MD GenREDII v2 = BOTH 3.01 MD GenRED II v1 and 3.01 MD GenRED II v2, not 3.01 MD GenRED I = BOTH 3.01 MD GenRED II v1 and 3.01 MD GenRED II v2, not 3.0 GenRED I * = BOTH 3.0 GenRED I and 3.01 MD GenRED II v1, not 3.01 MD GenRED II v2 CONTENTS SECTION NAME PAGE A. Demographics ....................................................................................................................... 1 B. Medical History..................................................................................................................... 11 B2. Medical History..................................................................................................................... 18 C1. Modified Mini-Mental Status Examination................................................................................ 24 C2. Telephone Interview for Cognitive Status................................................................................. 27 D. Somatization ......................................................................................................................... 29 E. Overview of Psychiatric Disturbance....................................................................................... 36 F. Major Depression .................................................................................................................. 51 G. Mania/Hypomania ................................................................................................................. 71 H. Dysthymia/Cyclothymia ......................................................................................................... 92 I. Alcohol Abuse and Dependence.............................................................................................. 97 J. Tobacco, Drug Abuse and Dependence ................................................................................... 109 K. Psychosis.............................................................................................................................. 132 L. Schizotypal Personality Features ............................................................................................. 154 M. Modified Structured Interview for Schizotypy (SIS).................................................................. 211 N. Comorbidity Assessment ........................................................................................................ 155 O. Suicidal Behavior................................................................................................................... 157 P. Anxiety Disorders .................................................................................................................. 164 Q. Eating Disorders .................................................................................................................... 172 R. Pathological Gambling............................................................................................................ 175 S. Antisocial Personality............................................................................................................. 176 T. Global Assessment Scale (GAS).............................................................................................. 179 U. Scale for the Assessment of Negative Symptoms (SANS).......................................................... 180 V. Scale for the Assessment of Positive Symptoms (SAPS) ........................................................... 183 W. Modified SIS Ratings ............................................................................................................. 239 X. Interviewer’s Reliability Assessment........................................................................................ 189 Y. Narrative Summary................................................................................................................ 191 Z. Medical Records Information.................................................................................................. 193 In reference section: Ethnicity Card Tobacco Tally Sheet Modified MMS Card Marijuana Tally Sheet Depression Tally Sheet Drug Use Card Mania Tally Sheet Drug Tally Sheet Alcohol Use Card Comorbidity Card Alcohol Tally Sheet In this section: A. DEMOGRAPHICS Page 1 INTERVIEWER: If it appears that the subject’s mental status is interfering with his/her ability to provide accurate information, skip to C1. Modified Mini-Mental Status Examination. Male Female 1. INTERVIEWER: Circle sex code. 0 1 Age 2. How old are you? No Yes Unk 3. Were you adopted? 0 1 9 If yes: Clarify nature of