MMP19 polyclonal antibody processes, such as embryonic development, reproduction, and tissue remodeling, as well as in Catalog Number: PAB4786 disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which Regulatory Status: For research use only (RUO) are activated when cleaved by extracellular proteinases. This protein is expressed in human epidermis and it has Product Description: Rabbit polyclonal antibody raised a role in cellular proliferation as well as migration and against synthetic peptide of MMP19. adhesion to type I collagen. Multiple transcript variants encoding distict isoforms have been identified for this Immunogen: A synthetic peptide (conjugated with KLH) gene. [provided by RefSeq] corresponding to C-terminus of human MMP19. References: Host: Rabbit 1. Matrix metalloproteinase 19 regulates insulin-like growth factor-mediated proliferation, migration, and Reactivity: Human adhesion in human keratinocytes through proteolysis of Applications: ELISA, Flow Cyt, IHC-P, WB-Ce insulin-like growth factor binding protein-3. Sadowski T, (See our web site product page for detailed applications Dietrich S, Koschinsky F, Sedlacek R. Mol Biol Cell. information) 2003 Nov;14(11):4569-80. Epub 2003 Aug 22. 2. Matrix metalloproteinase-19 is expressed by Protocols: See our web site at proliferating epithelium but disappears with neoplastic http://www.abnova.com/support/protocols.asp or product dedifferentiation. Impola U, Toriseva M, Suomela S, page for detailed protocols Jeskanen L, Hieta N, Jahkola T, Grenman R, Kahari VM, Saarialho-Kere U. Int J Cancer. 2003 Mar Form: Liquid 1;103(6):709-16. 3. Matrix metalloproteinase-19 is expressed in myeloid Purification: Protein G purification cells in an adhesion-dependent manner and associates with the cell surface. Mauch S, Kolb C, Kolb B, Sadowski Recommend Usage: ELISA (1:1000) T, Sedlacek R. J Immunol. 2002 Feb 1;168(3):1244-51. Western Blot (1:100-500) Immunohistochemistry (1:50-100) Flow cytometry (1:10-50) The optimal working dilution should be determined by the end user. Storage Buffer: In PBS (0.09% sodium azide) Storage Instruction: Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing. Entrez GeneID: 4327 Gene Symbol: MMP19 Gene Alias: MMP18, RASI-1 Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological Page 1/1 Powered by TCPDF (www.tcpdf.org).