Search Strategy – MEDLINE 1. Ventilator Weaning/ or ((Respirator* or Ventilator*) adj4 (wean or weaned or Weaning)).mp. 2. (wean or weaned or weaning).mp. 3. exp Positive Pressure Respiration/ or Interactive Ventilatory Support/ or Ventilators, Mechanical/ or Respiration, Artificial/ 4. (positive Pressure Respirat* or Positive Pressure Ventilat* or Positive End-Expiratory Pressure* or Continuous Positive Airway Pressure* or CPAP or nCPAP or APRV or Airway Pressure Release Ventilat* or Intermittent Positive Pressure Breathing or IPPB or Inspiratory Positive-Pressure Breathing or Intermittent Positive Pressure Ventilat* or IPPV or Inspiratory Positive Pressure Ventilat*).mp. 5. (Respirator or Respirators or Artificial Respirat* or Mechanical Ventilat* or Mechanically Ventilated or Pulmonary Ventilat* or Interactive Ventilatory Support* or NAVA or Neurally Adjusted Ventilatory Assist* or Proportional Assist Ventilat* or Proportional Assisted Ventilat* or Proportional Assistance Ventilat* or Proportionally Assisted Ventilat* or Interactive respiratory Support* or Neurally Adjusting Ventilatory Assist*).mp. 6. Airway Extubation/ or (extubat* adj4 (airway* or trachea* or intratrachea* or endotrachea*)).mp. 7. 3 or 4 or 5 or 6 8. exp Antipsychotic Agents/ or Antipsychotic/ or Major Tranquilizer/ or Major Tranquillizing/ or Neuroleptic/ 9. (acepromazine or amoxapine or asenapine or azaperone or benperidol or butaclamol or chlorpromazine or chlorprothixene or clopenthixol or clozapine or droperidol or flupenthixol or fluphenazine or fluspirilene or haloperidol or levomepromazine or loxapine or loxapine succinate or mesoridazine or methiothepin or methotrimeprazine or molindone or olanzapine or paliperidone or penfluridol or perazine or perphenazine or pimozide or prochlorperazine or promazine or quetiapine or remoxipride or reserpine or risperidone or ritanserin or spiperone or sulpiride or thioridazine or thiothixene or tiapride hydrochloride or trifluoperazine or trifluperidol or triflupromazine or ziprasidone).mp. 10. exp analgesics/ or exp opioids/ 11. (Opioid Analgesics or Opioids or Partial Opioid Agonists or Opioid Partial Agonists or Full Opioid Agonists or Opioid or Opioid Full Agonists or Opioid or Mixed Agonist-Antagonists or Opioid Mixed Agonist Antagonists).mp. 12. exp Analgesics, Opioid/ 13. (Alfentanil or Alphaprodine or Buprenorphine or Butorphanol or Codeine or Dextromoramide or Dextropropoxyphene or Dihydromorphine or Ethylketocyclazocine or Ethylmorphine or Etorphine or Fentanyl or Hydrocodone or Hydromorphone or Levorphanol or Meperidine or Meptazinol or Methadone or Methadol or Methadyl Acetate or Morphine or Nalbuphine or Opiate Alkaloids or Opium or Oxycodone or Oxymorphone or Pentazocine or Phenazocine or Phenoperidine or Pirinitramide or Promedol or Remifentanil or Sufentanil or Tilidine or Tramadol).mp. 14. (Adrenergic alpha 2 Receptor Agonists or Adrenergic alpha2-Agonists or Adrenergic alpha2 Agonists or Adrenergic alpha-2 Agonists or Adrenergic alpha 2 Agonists or Adrenergic alpha-2 Receptor Agonist or Adrenergic alpha 2 Receptor Agonist).mp. 15. (Klofenil or Clofenil or Chlophazolin or Clonidine or Clonidine Dihydrochloride or Clonidine Hydrochloride or Clonidine Monohydrochloride or Clonidine Monohydrobromide or Guanfacine or Lofexidine Gemiton or Hemiton or Isoglaucon or Klofelin or Clopheline or Clofelin or Catapres or Catapressan or Catapresan or Dixarit).mp. 16. Dexmedetomidine/ or (Dexmedetomidine or Precedex).mp. 17. exp Hypnotics/ and Sedatives/ 18. (Hypnotic* or Sedative*).mp. 19. (Buprenorphine or Naloxone or Naltrexone or naltrindole).mp. 20. exp Central nervous system stimulants/ 21. (Caffeine or Metadate or Equasym or Methylin or Modafinil or Concerta or Phenidylate or Ritalin or Ritaline or Ritalin-SR or Ritalin SR or Tsentedrin or Centedrin or Daytrana or Methylphenidate Hydrochloride).mp. 22. exp Amphetamine/ 23. (Amantadine or Apomorphine or Bromocriptine or Metergoline or Piribedil).mp. 24. (Gabapentin or Gabapentin enacarbil or Neurotin).mp. 25. 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 26. Therapeutics/ or (Therapeutic or Treatment or Therapy or Therapies).mp. 27. Acoustic Stimulation/ or Behavior Control/ or Hypnosis/ or Meditation/ or Relaxation Therapy/ 28. (Acoustic Stimulation or Auditory Stimulation or Behavior Control or Behavioral Manipulation).mp. 29. exp Complementary Therapies/ or Biofeedback, Psychology/ or Breathing Exercises/ or (Complementary Therapies or Alternative Medicine or acupuncture or Electroacupuncture or Mind-Body Therapies or Mind-Body medicine or Biofeedback or Psychophysiologic Feedback or Myofeedback or Neurofeedback or Breathing Exercise or hypnosis or Mesmerism or Meditation or Relaxation Therapy).mp. 30. 26 or 27 or 28 or 29 31. 1 and 25 32. 2 and 7 and 25 33. 32 not 31 34. 1 and 30 35. 34 not (31 or 32) 36. 2 and 7 and 30 37. 36 not (31 or 32 or 35) .