Journal of Investigational Allergology and Clinical Immunology ISSN 1018-9068 Volume 31, Supplement 1, 2021 Official Organ of Spanish Society of Allergology and Clinical Immunology www.jiaci.org GEMA5.0 SPANISH GUIDELINE ON THE MANAGEMENT OF ASTHMA Journal of Investigational Allergology and Clinical Immunology Volume 31, Suppl. 1, 2021 Official Organ of Spanish Society of Allergology and Clinical Immunology Editors in Chief A.G. Oehling, Servicio de Alergología, Clínica Rotger, C/ Santiago Rusiñol 3, E-07012 Palma de Mallorca, Spain (E-mail [email protected]) J.M. Olaguibel, Unidad de Asma Grave, Servicio de Alergología, Complejo Hospitalario de Navarra, C/Irunlarrea s/n, E-31008 Pamplona, Spain (Tel. +34 948 255-400, Fax +34 948 296-500, E-mail [email protected]) Associate Editors I. Dávila, Hospital Clínico Universitario, Paseo San Vicente s/n, E-37007 Salamanca, Spain P.M. Gamboa, Servicio de Alergología, Hospital de Cruces, Plaza de Cruces, s/n, E-48903 Baracaldo, Bizkaia, Spain R. Lockey, University of South Florida College of Medicine, Division of Allergy and Immunology, VA Medical Center, 13000 North 30th Street, Tampa, FL 33612, USA V. del Pozo, Senior Research, Immunology IIS-FJD, Avda. Reyes Católicos 2, E-28040 Madrid, Spain J. Sastre, Servicio de Alergia, Fundación Jiménez Díaz, Avda. Reyes Católicos 2, E-28040 Madrid, Spain J.M. Zubeldia, Servicio de Alergología, Hospital G.U. Gregorio Marañón, C/ Dr. Esquerdo 46, E-28007 Madrid, Spain Founding Editor A.K. Oehling †, Department of Allergology and Clinical Immunology, Clínica Universidad de Navarra, Apartado 4209, E-31008 Pamplona, Spain Editorial Assistant G. Betelu, Department of Allergology and Clinical Immunology, Clínica Universidad de Navarra, Apartado 4209, E-31008 Pamplona, Spain (Tel. +34 948 255-400, Fax +34 948 296-500, E-mail [email protected]) Editorial Board A Aghamohammadi, Tehran, Iran J Fernández Crespo, Madrid, Spain A Nieto García, Valencia, Spain CA Akdis, Davos, Switzerland E Fernández Ibáñez, Vitoria, Spain A Nowak-Wegrzyn, New York, USA L.K. Arruda, Sao Paulo, Brazil M Fernández Rivas, Madrid, Spain O Palomares, Madrid, Spain I Asher, Auckland, New Zealand M Ferrer, Pamplona, Spain N Papadopoulos, Athens, Greece D Barber, Madrid, Spain TA Fleisher, Bethesda, USA TAE Platts-Mills, Charlottesville, USA C Blanco Guerra, Madrid, Spain JA Fonseca, Porto, Portugal L Prieto Andrés, Valencia, Spain MT Caballero, Madrid, Spain A Fox, London, UK S Quirce, Madrid, Spain M AZ Calderón, London, UK B García, Pamplona, Spain JR Regueiro, Madrid, Spain B Cárdaba, Madrid, Spain L García Marcos, Murcia, Spain J Ring, Munich, Germany V Cardona, Barcelona, Spain G Gastaminza, Pamplona, Spain S Roa, Pamplona, Spain T Carrillo, Las Palmas de GC, Spain D Hernández, Valencia, Spain A Romano, Rome, Italy M Castells, Boston, USA MDP Ibáñez Sandín, Madrid, Spain M Sánchez Borges, Caracas, Venezuela T Chivato, Madrid, Spain AP Kaplan, Charleston, USA C Sanz, Salamanca, Spain SH Cho, Chicago, USA M Labrador, Barcelona, Spain E. Seoane, Madrid, Spain C Colás, Zaragoza, Spain S Lau, Berlin, Germany D Solé, Sao Paulo, Brazil G D’Amato, Naples, Italy R Madrigal-Burgaleta, London, UK A Tabar, Pamplona, Spain B de la Hoz, Madrid, Spain F Martínez, Tucson, USA R Valenta, Vienna, Austria J Delgado, Sevilla, Spain P Matricardi, Berlin, Germany AL Valero, Barcelona, Spain L Delgado, Porto, Portugal W Medrala, Wrocfaw, Poland C Vidal, La Coruña, Spain P Demoly, Montpellier, France J Mohaapatra, Tampa, USA L Vila, La Coruña, Spain SR Durham, London, UK C Moreno, Córdoba, Spain D Ebo, Antwerpen, Belgium R Muñoz, Barcelona, Spain The Editors and the Editorial Board of this Journal are respectful of all scientific criteria; however, they do not necessarily subscribe to the views expressed in all the articles published. Publisher ESMON PUBLICIDAD, S.A., Balmes, 209, 3º 2ª, 08006 Barcelona, Spain, Tel. +34 932 159 034, Fax +34 934 874 064, E-mail [email protected] Department of Allergy, Clínica Universidad de Navarra, Pío XII, 36, 31008 Pamplona, Spain. Subscriptions ESMON PUBLICIDAD, S.A., Balmes, 209, 3º 2ª, 08006 Barcelona, Spain, Tel. +34 932 159 034, Fax +34 934 874 064, E-mail [email protected] Advertising/Inserts ESMON PUBLICIDAD, S.A., Balmes, 209, 3º 2ª, 08006 Barcelona, Spain, Tel. +34 932 159 034, Fax +34 934 874 064, E-mail [email protected] ISSN ISSN: 1018-9068 - D.L.: B-12845-1991 Copyright ©2021 Esmon Publicidad, S.A. The journal, as well as the individual contributions to it, are protected under Information international copyright law. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, digital, mechanical, photocopying, microfilming, or otherwise, without prior written permission from the publisher. 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Single issue price: € 70.00 / US$95.00 Payment Payment may be made by check or international money order to Esmon Publicidad, S.A., Balmes 209, 3º 2ª, 08006 Barcelona, Spain Abstracting Journal of Investigational Allergology and Clinical Immunology is indexed/abstracted in Chemical Abstracts, Services Current Biology, Current Contents – Clinical Medicine, Database Subidase, Excerpta Medica – Immunology, Serology and Transplantation EMBASE, Index Medicus – Medline/Medlars, Pascal INIST, Science Citation Index © 2021 Esmon Publicidad GEMA5.0 SPANISH GUIDELINE FOR ASTHMA MANAGEMENT AEPap SEMES Asociación Española de Pediatría Sociedad Española de Medicina de Urgencias de Atención Primaria y Emergencias (Spanish Society of Urgent (Spanish Association of Primary Care Pediatrics) and Emergency Medicine) ALAT SEMFYC Asociación Latinoamericana del Tórax Sociedad Española de Medicina (Latin American Chest Association) Familiar y Comunitaria (Spanish Society of Family and Community Medicine) GRAP Sociedad de Respiratorio de Atención Primaria SEMG (Primary Care Respiratory Society) Sociedad Española de Médicos Generales y de Familia (Spanish Society of General SEAIC and Family Physicians) Sociedad Española de Alergología e Inmunología Clínica (Spanish Society of Allergology SENP and Clinical Immunology) Sociedad Española de Neumología SEFAC Pediátrica (Spanish Society Sociedad Española de Farmacia Familiar y of Pediatric Pneumology) Comunitaria (Spanish Society of Family SEORL-CCC and Community Pharmacy) Sociedad Española de Otorrinolaringología SEFC y Cirugía de Cabeza y Cuello Sociedad Española de Farmacología Clínica (Spanish Society of Otorhinolaryngology (Spanish Society of Clinical Pharmacology) and Head and Neck Surgery) SEFH SEPAR Sociedad Española de Farmacia Hospitalaria Sociedad Española de Neumología y Cirugía (Spanish Society of Hospital Pharmacy) Torácica (Spanish Society of Pneumology and Thoracic Surgery) SEICAP Sociedad Española de Inmunología Clínica, SEPEAP Alergología y Asma Pediátrica Sociedad Española de Pediatría (Spanish Society of Clinical Immunology, Extrahospitalaria y Atención Allergology and Pediatric Asthma) Primaria (Spanish Society of Outpatient and Primary Care Pediatrics) SEMERGEN Sociedad Española de Médicos de Atención SPP Primaria (Spanish Society of Primary Sociedad Portuguesa de Pneumologia Care Physicians) (Portuguese Society of Pneumology) With the external methodological review of INPECS, Institute for Clinical and Healthcare Excelence www.gemasma.com © 2021 Esmon Publicidad J Investig Allergol Clin Immunol 2021; Vol. 31, Suppl. 1 PARTICIPATING SCIENTIFIC SOCIETIES, GROUPS AND ASSOCIATIONS AEPap SEMES Asociación Española de Pediatría Sociedad Española de Medicina de Urgencias de Atención Primaria (Spanish Association y Emergencias (Spanish Society of Emergency of Primary Care Pediatrics) Medicine and Emergency Care) ALAT semFYC Asociación Latinoamericana del Tórax Sociedad Española de Medicina Familiar (Latin American Chest Association) y Comunitaria (Spanish Society of Family and Community Medicine) GRAP Sociedad de Respiratorio de Atención Primaria SEMG (Primary Care Respiratory Society) Sociedad Española de Médicos Generales y de Familia (Spanish Society of General SEAIC and Family Physicians) Sociedad Española de Alergología e Inmunología Clínica (Spanish Society SENP of Allergology and Clinical Immunology) Sociedad Española de Neumología Pediátrica (Spanish Society SEFAC of Pediatric Pneumology) Sociedad Española de Farmacia Familiar y Comunitaria (Spanish Society of Family SEORL-CCC and Community Pharmacy) Sociedad Española de Otorrinolaringología y Cirugía SEFC de Cabeza y Cuello Sociedad Española de Farmacología Clínica (Spanish Society of Otorhinolaryngology (Spanish Society of Clinical Pharmacology) and Head and Neck Surgery) SEFH SEPAR Sociedad Española de Farmacia Hospitalaria Sociedad Española de Neumología (Spanish Society of Hospital Pharmacy) y Cirugía Torácica (Spanish Society SEICAP of Pneumology and Thoracic Surgery) Sociedad Española de Inmunología Clínica, SEPEAP Alergología y Asma Pediátrica Sociedad Española de Pediatría (Spanish Society of Clinical Immunology, Extrahospitalaria y Atención Primaria Allergology and Pediatric Asthma) (Spanish Society of Outpatient and Primary Care Pediatrics) SEMERGEN Sociedad Española de Médicos SPP de Atención Primaria (Spanish Society Sociedad Portuguesa de Pneumologia of Primary Care Physicians) (Portuguese Society of Pneumology)