References Symbols Key P- 58181-D THC (Δ9-tetrahydrocannabinol) is the primary active ingredient in 1. Tietz, Norbert W. Textbook of Clinical Chemistry. W.B. Saun- cannabinoids (marijuana). When ingested or smoked, it produces ders Company. 1986, p. 1735. euphoric effects. Users experience impairment of short term 2. Hawks RL, Chiang CN, eds. Urine Testing for Drugs of Abuse. DS memory and THC use slows learning. Also, it may cause transient Instructions For Use (Read) episodes of confusion, anxiety, or frank toxic delirium. Long term, National Institute on Drug Abuse (NIDA), Research Monograph THC/OPI/COC/AMP/BZO/BAR/TCA/PCP relatively heavy use may be associated with behavioral disorders. 73; 1986. REF Item Number One-Step Panel Test for Drugs of Abuse The peak effect of smoking THC occurs in 20–30 minutes and the 3. Baselt RC. Disposition of Toxic Drugs and Chemicals in Man. duration is 90–120 minutes after one cigarette. Elevated levels of 2nd Ed., Davis, CA: Biomedical Publ.; 1982; p.488. Store At For In Vitro Use Only urinary metabolites are found within hours of exposure and remain 4. Stewart DJ, Inoba T, Ducassen M, and Kalow W. Clin. Pharma- detectable for 3–10 days after smoking. The main metabolite col. Ther. 1979;25: 264–8. excreted in the urine is 11-nor-Δ9-tetrahydrocannabinol-9 Expiration Date Simple One-Step Immunoassay 1 5. Ambre JJ. Anal. Toxicol. 1985;9:241–5. -carboxylic acid. for the Qualitative Detection of Opiates, Cocaine, THC, 6. Blum K. Handbook of Abusable Drugs. 1st ed. New York: Gardner Press, Inc.; 1984. CONT Contents Phencyclidine, Benzodiazepines, Barbiturates, Tricyclic Phencyclidine is an arylcyclohexylamine that is used as a 7. Fairlight Consulting. Antidepressants, Amphetamine, and/or their Metabolites in veterinary anesthetic. It is used illegally as a hallucinogen, and is http://www.fairlite.com/ocd/articles/tricyclic.shtml IFU Instructions For Use Urine commonly referred to as PCP, angel dust, love boat, hog, or killer weed. PCP can produce lethargy, euphoria, ataxia, nystagmus 8. Bickel MH. Poisoning by Tricyclic Antidepressant Drugs. Int. J. and coma. Currently a number of PCP analogues with similar Clinical Pharmacol. 11 (1975) 145-176 (No. 2). PIP Transfer Pipette pharmacological effects are in use as street drugs, including PCE, LifeSign, LLC PHP, TCP, and ketamine. Phencyclidine is readily absorbed when IVD For In Vitro Diagnostic Use smoked or ingested, or even through skin contact. It is Item No. 28010 10 Test Kit metabolized in the liver. Evidence indicates that PCP undergoes oxidative metabolism to at least 2 inactive metabolites, LOT Lot Number Item No. 28025 25 Test Kit 4-phenyl-4-piperidino-cyclohexanol and 1-(1-phenylcyclohexyl)-4-hydroxypiperidine, which are excreted as Manufacturer glucuronide conjugates in the urine. About 10% of the dose is Intended Use excreted in urine as the parent compound, phencyclidine.2,3 MF Manufactured For Benzodiazepines are a class of widely prescribed central nervous Status DS 8 Panel (THC/OPI/COC/AMP/BZO/BAR/TCA/PCP) system (CNS) depressants and include widely used drugs such as EC REP Authorized Representative test is a simple, one-step immunochromatographic assay for the rapid, qualitative detection of opiates, cocaine, THC, phencyclidine, chlordiazepoxide, diazepam, and oxazepam. They have medically benzodiazepines, barbiturates, tricyclic antidepressants, useful properties, including antianxiety, sedative, anticonvulsant, CE Mark amphetamine, and/or their metabolites present in human urine at and hypnotic effects. They are taken orally or sometimes by the cutoff concentration of the drug specified, see Expected Values. injection, and have a low potential for physical or psychological dependence. Benzodiazepines induce drowsiness and muscle Status DS 8Panel (THC/OPI/COC/AMP/BZO/BAR/TCA/PCP) relaxation; however, their use can also result in intoxication, similar test provides only a preliminary analytical result. A more to drunken behavior except without evidence of alcohol use, and specific alternative chemical method must be used in order to the loss of inhibitions. Chronic abuse can result in addiction and obtain a confirmed analytical result. Gas chromatography, tardive dyskinesia (involuntary muscle movements of the face, mass spectrometry (GC/MS) is the preferred confirmatory limbs, and trunk). Overdose can result in coma and possible method. Other chemical confirmatory methods are available. death. Withdrawal syndrome includes anxiety, insomnia, tremors, Clinical consideration and professional judgment should be delirium, and convulsions. The effects of benzodiazepine use last applied to any drug of abuse test result, particularly when 4–8 hours. The different benzodiazepines are absorbed at different preliminary positive results are used.2 rates, and the timing of their psychoactive effects varies with the absorption rate. The drugs are excreted in the urine primarily as Summary and Explanation the parent compounds or as oxazepam glucuronide, an inactive Morphine, codeine, and semisynthetic derivatives of morphine metabolite, (in the case of chlordiazepoxide and diazepam) and are detectable for 1–2 days. Oxazepam may be detectable in the belong to the class of drugs called opiates. An opiate exerts its 2,3 effects on the central nervous system and can produce euphoria, urine for up to 7 days. respiratory depression and coma when it is abused. Morphine is the prototype compound of opiates. Morphine is excreted in the Barbiturates are a group of chemicals derived from barbituric urine as morphine-3-glucuronide, unchanged morphine, and other acid. Classified as hypnotics, they depress the central nervous minor metabolites. Heroin is metabolized to morphine and codeine system. Taken orally in pill or tablet form, they are prescribed for and excreted in the urine with a small amount of unchanged form. many medical conditions, usually for their sedative effect. Abuse Codeine is also excreted as morphine and in the form of of barbiturates can, however, lead not only to impaired motor conjugates. Although some opiate metabolites appear in the feces, 1,2,3 coordination and mental disorder, but also to respiratory collapse, urinary excretion is the primary route of elimination. coma and death. The combination of barbiturates and alcohol is particularly dangerous. Symptoms of barbiturate abuse include Cocaine, derived from the leaves of coca plant, is a potent central drowsiness, slurred speech and irritability. Acute conditions nervous system (CNS) stimulant and a local anesthetic. Cocaine include respiratory collapse and loss of consciousness. Chronic induces euphoria, confidence and a sense of increased energy in conditions include addiction, abstinence and seizures. The effects the user; these psychological effects are accompanied by increased of short-acting barbiturates such as pentobarbital and heart rate, dilation of the pupils, fever,tremors and sweating. secobarbital last 3 to 6 hours. The effects of long-acting Cocaine is used by smoking, intravenous, intranasal or oral barbiturates last 10 to 20 hours. Phenobarbital is an example of administration, and excreted in the urine primarily as long-acting ones. Barbiturates normally remain detectable in urine benzoylecgonine in a short time. Benzoylecgonine has a longer for 4 to 6 days in the case of short-acting ones and up to 30 days Printed in U.S.A. EC REP Manufactured by MF Manufactured for: biological half-life (5–8 hours) than cocaine (0.5–1.5 hours) and can for long-acting ones. Short-acting barbiturates are generally P-58181-D generally be detected for 24–60 hours after cocaine use or excreted as metabolites, while long-acting ones primarily appear 33-7/11/12 MT Promedt Consulting GmbH exposure.3,5 unchanged.2,3 Altenhofstrasse 80 66386 St. Ingbert Princeton BioMeditech Corporation Germany 4242 U.S. Hwy 1, Monmouth Jct. A PBM Group Company +49-68 94-58 10 20 New Jersey 08852, U.S.A. 85 Orchard Road, 1-732-274–1000 www.pbmc.com Skillman, NJ 08558 800-526-2125, 732-246-3366 www.lifesignmed.com 8 1 Tricyclic antidepressants (TCAs) are a type of prescription drug • Status DS 8 Panel(THC/OPI/COC /AMP/BZO/BAR/TCA/PCP) COC AMP intended for clinically depressed patients. Unfortunately, they are device. The test device contains membrane strips and dye Benzoylecgonine 300 D-Amphetamine 1,000 pads: Membrane strips are coated with THC-protein (a Cocaine HCl >100,000 D,L-Amphetamine 1,800 becoming more frequently abused and are now one of the leading L-Amphetamine 37,500 purified bovine protein) conjugate, PCP-protein (a purified Ecgonine HCl >100,000 causes of death by drug overdose in the United States. There are Benzphetamine >100,000 two broad chemical classes of TCAs. The tertiary bovine protein) conjugate, monoclonal , anti-morphine, THC D-Methamphetamine >100,000 amines—amitriptyline, imipramine, trimipramine and anti-benzoylecgonine, anti-barbiturate, and Cannabinol >100,000 p-OH-Methamphetamine >100,000 doxepin—boost serotonin levels and are prescribed for insomnia, anti-amphetamine antibodies, as well as polyclonal 11-hydroxy-Δ9-THC 7,500 Methylenedioxyamphetamine 2,000 irritability and over stimulation. The secondary anti-oxazepam, anti-methadone, and anti-tricyclic 11-nor-Δ8-THC-9-COOH 250 Methlyenedioxymethamphetamine >100,000 amines—nortriptyline, desipramine and protryptiline—enhance antidepressant antibodies. Sheep anti-mouse antibody is 11-nor-Δ9-THC-9-COOH 50 ß-Phenylethylamine 40,000 norepinephrine levels and are prescribed for opposite types of coated for the control