YEAR CENTENNIAL THE LABORATORY HARBOR SPRING COLD ANNUAL REPORT 1990 COLD SPRING HARBOR LABORATORY THE CENTENNIAL YEAR ANNUAL REPORT 1990 Cold Spring Harbor Laboratory Box 100 1 Bungtown Road Cold Spring Harbor, New York 11724 Book design Emily Harste Editors Dorothy Brown, Lee Martin Photography Margot Bennett, Herb Parsons, Edward Campodonico Typography Marie Sullivan Front cover: Jones Laboratory, during the Centennial fireworks dis- play. This building, completed in 1893, was the first structure built expressly for science at Cold Spring Harbor. (Photograph by Ross Meurer and Margot Bennett.) Back Cover: (Top) Centennial reenactment of the first biology class at Cold Spring Harbor on board the launch "Rotifer." (Inset) The original class of 1890. Reenactments for the Centennial were directed by Rob Gensel. (Photograph by Randy Wilfong.) (Bottom) Centennial reenactment of the Laboratory's first biology class on the Jones Laboratory porch. (Inset) The original 1890 class on the porch of the old Fish Hatchery building before the completion of Jones Laboratory. (Photograph by Margot Bennett.) Contents Officers of the Corporation/Board of Trustees v Governance and Major Affiliations vi Committees vii Edward Pulling (1898-1991)viii DIRECTOR'S REPORT DEPARTMENTAL REPORTS 21 Administration 23 Buildings and Grounds 25 Development 28 Library Services 30 Public Affairs 32 RESEARCH 35 Tumor Viruses 37 Molecular Genetics of Eukaryotic Cells 93 Genetics 155 Structure and Computation 197 Neuroscience 213 CSH Laboratory Junior Fellows217 COLD SPRING HARBOR MEETINGS 221 Symposium on Quantitative Biology 223 Meetings226 BANBURY CENTER 247 Director's Report 249 Meetings 257 COLD SPRING HARBOR LABORATORY PRESS 279 DNA LEARNING CENTER 287 EDUCATIONAL ACTIVITIES 309 Postgraduate Courses 311 Seminars 335 Undergraduate Research 337 Nature Study 339 FINANCIAL STATEMENT 341 FINANCIAL SUPPORT OF THE LABORATORY 347 Sources of Support349 Grants 351 Annual Contributions358 Corporate Sponsor Program 360 Second Century Campaign 361 LONG ISLAND BIOLOGICAL ASSOCIATION 365 LABORATORY STAFF 379 (Front row) Mrs. G.G. Montgomery, J.D. Watson, Mrs. J.H. Hazen, L.J. Landeau (Middle row) W.S. Robertson, D.L. Luke, W. Everdel, T. Knight, D. Sabatini, T. Maniatis, B.D. Clarkson, J.R. Warner, T. Silhavy, G.W. Cutting, F.M. Richards (Back row) W.H. Page, O.R. Grace, T.M. Jessell, W.R. Miller, J. Darnell, S. Strickland, O.T. Smith, J.R. Reese, D. Botstein, D.B. Pall Not shown: C.F. Dolan, M. Lindsay, T. Whipple, M. Cowan, S. Tilghman Officers of the Corporation Bayard D. Clarkson, M.D., Chairman Taggart Whipple, Vice-Chairman Oliver R. Grace, Secretary David L. Luke III, Treasurer James D. Watson, Ph.D., Director G. Morgan Browne, Administrative Director Board of Trustees Institutional Trustees Individual Trustees Honorary Trustees Albert Einstein College of Medicine David Botstein, Ph.D. Robert L. Cummings Jonathan R. Warner, Ph.D. Belmont, California Glen Head, New York Columbia University Charles F. Dolan Harry Eagle, M.D. Thomas M. Jessell, Ph.D. Oyster Bay, New York Mamaroneck, New York Harvard University William Everdell H. Bentley Glass, Ph.D. Thomas Maniatis, Ph.D. Glen Head, New York East Setauket, New York Howard Hughes Medical Institute Oliver R. Grace Walter H. Page W. Maxwell Cowan, M.D., Ph.D. Oyster Bay, New York Cold Spring Harbor, New York Long Island Biological Association Mrs. Joseph H. Hazen Edward Pulling* George W. Cutting, Jr. New York, New York Oyster Bay, New York Memorial Sloan-Kettering Cancer Laurie Landeau, D.V.M. Center Northport, New York Bayard D. Clarkson, M.D. Mrs. George Lindsay New York University Medical Center New York, New York David D. Sabatini, M.D., Ph.D. David L. Luke III Princeton University New York, New York Shirley M.C. Tilghman, Ph.D. William R. Miller Rockefeller University New York, New York James E. Darnell, Jr., M.D. Mrs. George G. Montgomery, Jr. State University of New York, New York, New York Stony Brook David B. Pall, Ph.D. Sidney Strickland, Ph.D. Roslyn Estates, New York Wawepex Society John R. Reese Townsend J. Knight Cold Spring Harbor, New York Yale University William S. Robertson Frederic W. Richards, Ph.D. Huntington, New York Owen T. Smith Laurel Hollow, New York James D. Watson, Ph.D Cold Spring Harbor, New York Taggart Whipple Oyster Bay, New York *deceased, April 17, 1991 Governance and Major Affiliations The Laboratory is governed by a 30-member Board of Trustees which meets three or four times a year. Authority to act for the Board of Trustees between meetings is vested in the Executive Committee of the Board of Trustees, The Executive Committee is composed of the Officers of the Board plus any other members who may be elected to the Executive Committee by the Board of Trustees. Additional standing and ad hoc committees are appointed by the Board of Trustees to provide guidance and advice in specific areas of the Laboratory's operations. Representation on the Board of Trustees itself is divided between community representatives and scientists from major research institutions. Ten such institutions are presently represented on the Board of Trustees: Albert Einstein College of Medicine, Columbia University, Harvard University, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York University Medical Center, Princeton University, The Rockefeller University, The State University of New York at Stony Brook, and Yale University. Also represented as a participating institution is the Long Island Biological Association (LIBA). LIBA's origins began in 1890 when members of the local community became involved as friends and with membership on the Board of Managers of the Biological Station in Cold Spring Harbor, under the aegis of the Brooklyn Academy of Arts and Sciences. When the Brooklyn Academy withdrew its support of the Biological Station, community leaders, in 1924, organized their own association that actually administered the Laboratory until the Laboratory's reorganization as an independent unit in 1962. Today, LIBA remains a nonprofit organization organized under the Department of Social Welfare of the State of New York and represents a growing constituency of "friends of the Laboratory." Its 900 members support the Laboratory through annual contributions and participation in fund drives to raise money for major construction projects. The Laboratory is chartered as an educational and research institution by the Board of Regents of the Education Department of the State of New York. It is designated as a "public charity" by the Internal Revenue Service. Committees" Audit DNA Learning Center Robertson House William Everdell, Chairman Mrs. Sinclair Hatch, Chairman William S. Robertson, Chairman George W. Cutting, Jr. David Botstein, Ph.D. Mrs. Walter Meier Townsend J. Knight William Everdell Jan A. Witkowski, Ph.D. Laurie Landeau, D.V.M. Mrs. Henry U. Harris Jack Richards John R. Reese Mrs. Walter Meier David Mick los Mrs. George G. Montgomery, Jr. Robertson Research Fund Banbury Program David D. Sabatini, M.D., Ph.D. (Laboratory Representatives) Owen T. Smith David Botstein, Ph.D., Chairman Byam K. Stevens David L. Luke Ill, Chairman Laurie Landeau, D.V.M. G. Morgan Browne Sidney Strickland, Ph.D. Jonathan R. Warner, Ph.D. Executive Committee Bayard D. Clarkson, M.D. Jan A. Witkowski, Ph.D. James D. Watson, Ph.D. Bayard D. Clarkson, M.D Chairman Taggart Whipple G. Morgan Browne (Family Representatives) Building George W. Cutting, Jr. William Everdell Mrs. Robert J. Ernst Mrs. Charles F. Dolan, Chairman Oliver R. Grace Townsend J. Knight George W. Cutting, Jr. David L. Luke Ill Walter Meier, M.D. Mrs. Sinclair Hatch William R. Miller William S. Robertson Mrs. George Lindsay James D. Watson, Ph.D. Mrs. George G. Montgomery, Jr. Taggart Whipple Jack Richards Tenure and Appointments Mrs. James D. Watson Finance and Investment James E. Darnell, Jr., Chairman David Botstein, Ph.D. David L. Luke Ill, Chairman W. Maxwell Cowan, M.D., Ph.D. Commercial Relations G. Morgan Browne Thomas Maniatis, Ph.D. Charles F. Dolan William R. Miller, Chairman Frederic W. Richards, Ph.D. William Everdell William Everdell David D. Sabatini, M.D., Ph.D. Oliver R. Grace Townsend J. Knight Shirley M.C. Tilghman, Ph.D. John Maroney Mrs. George Lindsay Richard Roberts, Ph.D. William Keen Owen T. Smith Townsend J. Knight Bruce Stillman, Ph.D. Laurie Landeau, D.V.M. Taggart Whipple William R. Miller John R. Reese William S. Robertson Development Taggart Whipple 2nd Century Fund David L. Luke III, Chairman Neurobiology G. Morgan Browne Thomas M. Jessell, Ph.D., Chairman Bayard D. Clarkson, M.D. W. Maxwell Cowan, M.D., Ph.D. George W. Cutting, Jr. Eric Kandel, M.D. Oliver R. Grace Walter Meier, M.D. Mrs. Sinclair Hatch Charles F. Stevens, Ph.D. Townsend J. Knight Laurie Landeau, D.V.M. Konrad Matthaei Nominating James D. Watson, Ph.D. Taggart Whipple, Chairman Taggart Whipple Bayard D. Clarkson, M.D. George W. Cutting, Jr. Mrs. George Lindsay David L. Luke Ill * Officers, Trustees, and Committees as of November 3, 1990 Edward Pulling (1898-1991) Edward Pulling, who died on April 17, 1991 at the age of 92, was a truly re- markable man whose career embodied the virtues of education, family life, and devotion to service for the public good. In his dual roles, as a trustee of this Lab and as Chairman of the Long Island Biological Association, he played an in- valuable role in the Laboratory's achievements over the past two decades. My wife and I will always remember the gracious way Ed and his wife Lucy brought us into their world when we first arrived in this community in the summer of 1968. By then, he had retired as the founding headmaster of the Millbrook School and they had moved to Oyster Bay to live in "Redcote," their home on Yellowcote Road which Lucy had inherited upon the death of her father.